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Shkbp1 Sh3kbp1 binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 192192, updated on 5-Mar-2024

Summary

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Official Symbol
Shkbp1provided by MGI
Official Full Name
Sh3kbp1 binding protein 1provided by MGI
Primary source
MGI:MGI:2385803
See related
Ensembl:ENSMUSG00000089832 AllianceGenome:MGI:2385803
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sb1; B930062H15Rik
Summary
Predicted to enable identical protein binding activity. Involved in positive regulation of epidermal growth factor receptor signaling pathway. Predicted to be located in lysosome. Orthologous to human SHKBP1 (SH3KBP1 binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 26.6), spleen adult (RPKM 26.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 A3; 7 15.88 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (27041553..27055440, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27342128..27356015, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene numb-like Neighboring gene ribosomal protein L14 pseudogene Neighboring gene STARR-seq mESC enhancer starr_18356 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28101108-28101366 Neighboring gene latent transforming growth factor beta binding protein 4 Neighboring gene STARR-positive B cell enhancer ABC_E4907 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28117793-28117976 Neighboring gene predicted gene, 30543 Neighboring gene STARR-positive B cell enhancer ABC_E1726 Neighboring gene STARR-positive B cell enhancer ABC_E1727 Neighboring gene STARR-positive B cell enhancer ABC_E2820 Neighboring gene spectrin beta, non-erythrocytic 4 Neighboring gene STARR-seq mESC enhancer starr_18360 Neighboring gene STARR-positive B cell enhancer ABC_E4908 Neighboring gene STARR-positive B cell enhancer ABC_E2230 Neighboring gene biliverdin reductase B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Suppression of tumor growth and metastasis in Shkbp1 knockout mice. Liu Q, et al. Cancer Gene Ther, 2022 Jun. PMID 34112919
  2. Interactions between CAP70 and actinfilin are important for integrity of actin cytoskeleton structures in neurons. Chen Y, et al. Neuropharmacology, 2005 Dec. PMID 16054660
  3. SH3KBP1-binding protein 1 prevents epidermal growth factor receptor degradation by the interruption of c-Cbl-CIN85 complex. Feng L, et al. Cell Biochem Funct, 2011 Oct. PMID 21830225, Free PMC Article
  4. SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins. Borinstein SC, et al. Cell Signal, 2000 Dec. PMID 11152963
  5. CIN85 interacting proteins in B cells-specific role for SHIP-1. Büchse T, et al. Mol Cell Proteomics, 2011 Oct. PMID 21725061, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CD8 + T-cell number and function are altered by Shkbp1 knockout mediated suppression of tumor growth in mice.
    Title: CD8 + T-cell number and function are altered by Shkbp1 knockout mediated suppression of tumor growth in mice.
  2. Suppression of tumor growth and metastasis in Shkbp1 knockout mice.
    Title: Suppression of tumor growth and metastasis in Shkbp1 knockout mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SH3KBP1-binding protein 1
Names
SETA binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138676.2 → NP_619617.2  SH3KBP1-binding protein 1

    See identical proteins and their annotated locations for NP_619617.2

    Status: VALIDATED

    Source sequence(s)
    BB847999, BC061477
    Consensus CDS
    CCDS21018.1
    UniProtKB/Swiss-Prot
    Q3TUN8, Q6P7W2, Q9ES31
    Related
    ENSMUSP00000003857.7, ENSMUST00000003857.7
    Conserved Domains (1) summary
    cd18393
    Location:18 → 120
    BTB_POZ_SHKBP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in SH3KBP1-binding protein 1 (SHKBP1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    27041553..27055440 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152797.1 → XP_036008690.1  SH3KBP1-binding protein 1 isoform X3

    Conserved Domains (1) summary
    cd18393
    Location:18 → 120
    BTB_POZ_SHKBP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in SH3KBP1-binding protein 1 (SHKBP1)

  2. XM_017322044.1 → XP_017177533.1  SH3KBP1-binding protein 1 isoform X2

    Conserved Domains (1) summary
    cd18393
    Location:18 → 120
    BTB_POZ_SHKBP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in SH3KBP1-binding protein 1 (SHKBP1)

  3. XM_006539667.2 → XP_006539730.2  SH3KBP1-binding protein 1 isoform X1

    Related
    ENSMUST00000123190.8
    Conserved Domains (1) summary
    cd18393
    Location:18 → 120
    BTB_POZ_SHKBP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in SH3KBP1-binding protein 1 (SHKBP1)

  4. XM_006539668.2 → XP_006539731.1  SH3KBP1-binding protein 1 isoform X4

    Related
    ENSMUST00000132684.8

RNA

  1. XR_003946420.1 RNA Sequence

  2. XR_881667.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P7W2.1 GenPept UniProtKB/Swiss-Prot:Q6P7W2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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