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Sugct succinyl-CoA glutarate-CoA transferase [ Mus musculus (house mouse) ]

Gene ID: 192136, updated on 12-Mar-2024

Summary

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Official Symbol
Sugctprovided by MGI
Official Full Name
succinyl-CoA glutarate-CoA transferaseprovided by MGI
Primary source
MGI:MGI:1923221
See related
Ensembl:ENSMUSG00000055137 AllianceGenome:MGI:1923221
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5033411D12Rik
Summary
Predicted to enable succinate-hydroxymethylglutarate CoA-transferase activity. Located in mitochondrion. Human ortholog(s) of this gene implicated in glutaric acidemia type 3. Orthologous to human SUGCT (succinyl-CoA:glutarate-CoA transferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 8.4), liver adult (RPKM 3.1) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Sugct in Genome Data Viewer
Location:
13 A2; 13 5.92 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (17032057..17869380, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (16857472..17694795, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31711 Neighboring gene STARR-seq mESC enhancer starr_33744 Neighboring gene STARR-seq mESC enhancer starr_33745 Neighboring gene STARR-seq mESC enhancer starr_33747 Neighboring gene STARR-seq mESC enhancer starr_33748 Neighboring gene STARR-seq mESC enhancer starr_33749 Neighboring gene STARR-seq mESC enhancer starr_33750 Neighboring gene STARR-seq mESC enhancer starr_33751 Neighboring gene STARR-seq mESC enhancer starr_33754 Neighboring gene CNDP dipeptidase 2 (metallopeptidase M20 family) pseudogene Neighboring gene STARR-seq mESC enhancer starr_33757 Neighboring gene STARR-seq mESC enhancer starr_33758 Neighboring gene STARR-seq mESC enhancer starr_33759 Neighboring gene STARR-seq mESC enhancer starr_33760 Neighboring gene predicted gene, 25020 Neighboring gene choroidermia pseudogene Neighboring gene STARR-seq mESC enhancer starr_33761 Neighboring gene predicted gene, 24873 Neighboring gene STARR-seq mESC enhancer starr_33762 Neighboring gene STARR-positive B cell enhancer ABC_E1869 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:17787115-17787302 Neighboring gene STARR-seq mESC enhancer starr_33763 Neighboring gene predicted gene, 40826 Neighboring gene M-phase specific PLK1 intereacting protein Neighboring gene microRNA 466i Neighboring gene cyclin dependent kinase 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype. Niska-Blakie J, et al. Cell Mol Life Sci, 2020 Sep. PMID 31722069, Free PMC Article
  2. Glutaric aciduria type 3 is a naturally occurring biochemical trait in inbred mice of 129 substrains. Leandro J, et al. Mol Genet Metab, 2021 Feb. PMID 33483254
  3. Molecular genetic studies of human chromosome 7 in Russell-Silver syndrome. Nakabayashi K, et al. Genomics, 2002 Feb. PMID 11829489
  4. Expression profiles of active genes in human and mouse livers. Kawamoto S, et al. Gene, 1996 Sep 26. PMID 8863742
  5. Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways. Narayan SB, et al. PLoS One, 2012. PMID 22496890, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Glutaric aciduria type 3 is a naturally occurring biochemical trait in inbred mice of 129 substrains.
    Title: Glutaric aciduria type 3 is a naturally occurring biochemical trait in inbred mice of 129 substrains.
  2. Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype.
    Title: Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables succinate-hydroxymethylglutarate CoA-transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables succinate-hydroxymethylglutarate CoA-transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
succinate--hydroxymethylglutarate CoA-transferase
Names
succinylCoA:glutarate-CoA transferase
NP_619595.3
XP_011242592.1
XP_036013805.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138654.3 → NP_619595.3  succinate--hydroxymethylglutarate CoA-transferase

    See identical proteins and their annotated locations for NP_619595.3

    Status: VALIDATED

    Source sequence(s)
    AA108199, AC154368, AK160265, CJ068463
    Consensus CDS
    CCDS26252.1
    UniProtKB/Swiss-Prot
    G3X9F8, Q7TNE1
    UniProtKB/TrEMBL
    Q3TV98
    Related
    ENSMUSP00000070759.5, ENSMUST00000068545.6
    Conserved Domains (1) summary
    COG1804
    Location:34 → 430
    CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    17032057..17869380 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157912.1 → XP_036013805.1  succinate--hydroxymethylglutarate CoA-transferase isoform X1

    UniProtKB/TrEMBL
    Q3TV98
    Conserved Domains (1) summary
    COG1804
    Location:32 → 388
    CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]

  2. XM_011244290.4 → XP_011242592.1  succinate--hydroxymethylglutarate CoA-transferase isoform X2

    UniProtKB/TrEMBL
    Q3TV98
    Conserved Domains (1) summary
    pfam02515
    Location:39 → 377
    CoA_transf_3; CoA-transferase family III
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TNE1.2 GenPept UniProtKB/Swiss-Prot:Q7TNE1

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