Ptcra pre T cell antigen receptor alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptcraprovided by MGI
Official Full Name: pre T cell antigen receptor alphaprovided by MGI
Primary source: MGI:MGI:104857
See related: Ensembl:ENSMUSG00000036858 AllianceGenome:MGI:104857
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: pTa; gp33; pT[a]; pTalpha; pT-alpha; pT-alpha-TCR
Summary: Acts upstream of or within negative regulation of thymocyte apoptotic process. Predicted to be located in plasma membrane. Is expressed in thymus and thymus primordium. Orthologous to human PTCRA (pre T cell antigen receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward thymus adult (RPKM 45.7) See more
Orthologs: human all
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Genomic context

Location:: 17 C; 17 22.9 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (47066589..47074659, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (46755663..46763712, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

pre-TCR expression is not essential for thymic differentiation to DP cells or for V-DJbeta suppression
Title: The requirement for pre-TCR during thymic differentiation enforces a developmental pause that is essential for V-DJβ rearrangement.
expression is up-regulated in regulatory T cells
Title: Notch3 and pTalpha/pre-TCR sustain the in vivo function of naturally occurring regulatory T cells.
pTalpha plays a role in protecting developing thymocytes from DNA damage in mice
Title: Molecular mechanisms of pre-T cell receptor-induced survival.
the dosage of E2A, HEB, and SCL determines pT alpha gene expression in immature T cells
Title: Regulation of pT alpha gene expression by a dosage of E2A, HEB, and SCL.
when in competition with pTalpha, TCRalpha induced defective proliferation, survival, and differentiation of alphabeta T lymphocyte precursors
Title: Pre-TCRalpha and TCRalpha are not interchangeable partners of TCRbeta during T lymphocyte development.
The cytoplasmic tail of pTalpha plays a critical role in T lymphocyte development.
Title: A critical role for the cytoplasmic tail of pTalpha in T lymphocyte development.
Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis
Title: Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

U27268 (e-PCR)
- UniSTS:125705

NoName (e-PCR)
- UniSTS:492592

Tcra (e-PCR), detects polymorphism
- UniSTS:259190

U16958 (e-PCR)
- UniSTS:160665

Ptcra (e-PCR), detects polymorphism
- UniSTS:548076

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in negative regulation of thymocyte apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of thymocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of thymocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: pre T-cell antigen receptor alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011195.3 → NP_035325.2 pre T-cell antigen receptor alpha precursor

Status: VALIDATED

Source sequence(s)

CT030702

Consensus CDS

CCDS28840.1

UniProtKB/Swiss-Prot

P0C6B2

Related

ENSMUSP00000035683.9, ENSMUST00000041012.9