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Pstpip2 proline-serine-threonine phosphatase-interacting protein 2 [ Mus musculus (house mouse) ]

Gene ID: 19201, updated on 11-Apr-2024

Summary

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Official Symbol
Pstpip2provided by MGI
Official Full Name
proline-serine-threonine phosphatase-interacting protein 2provided by MGI
Primary source
MGI:MGI:1335088
See related
Ensembl:ENSMUSG00000025429 AllianceGenome:MGI:1335088
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
cmo; MAYP
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in actin filament polymerization. Located in cytoskeleton; cytosol; and membrane. Orthologous to human PSTPIP2 (proline-serine-threonine phosphatase interacting protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 9.6), small intestine adult (RPKM 8.3) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 E3; 18 52.38 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (77882250..77971462)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (77794550..77882879)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_45130 Neighboring gene HAUS augmin-like complex, subunit 1 Neighboring gene predicted gene, 52331 Neighboring gene STARR-seq mESC enhancer starr_45133 Neighboring gene RIKEN cDNA F830208F22 gene Neighboring gene ATP synthase F1 subunit alpha Neighboring gene STARR-positive B cell enhancer mm9_chr18:78030749-78031049 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:78061325-78061621 Neighboring gene STARR-positive B cell enhancer ABC_E2514 Neighboring gene ectopic P-granules 5 autophagy tethering factor Neighboring gene sialic acid binding Ig-like lectin 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular interactions of adaptor protein PSTPIP2 control neutrophil-mediated responses leading to autoinflammation. Pavliuchenko N, et al. Front Immunol, 2022. PMID 36605205, Free PMC Article
  2. PSTPIP2 regulates synovial macrophages polarization and dynamics via ERβ in the joint microenvironment. Yao Y, et al. Arthritis Res Ther, 2022 Nov 2. PMID 36324152, Free PMC Article
  3. PSTPIP2 connects DNA methylation to macrophage polarization in CCL4-induced mouse model of hepatic fibrosis. Yang Y, et al. Oncogene, 2018 Nov. PMID 29993036
  4. Increased neutrophil infiltration, IL-1 production and a SAPHO syndrome-like phenotype in PSTPIP2-deficient mice. Liao HJ, et al. Rheumatology (Oxford), 2015 Jul. PMID 25602062
  5. PSTPIP2 deficiency in mice causes osteopenia and increased differentiation of multipotent myeloid precursors into osteoclasts. Chitu V, et al. Blood, 2012 Oct 11. PMID 22923495, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PSTPIP2 alleviates obesity associated adipose tissue inflammation and insulin resistance in diabetes mice through promoting M2 macrophage polarization via activation of PPARgamma.
    Title: PSTPIP2 alleviates obesity associated adipose tissue inflammation and insulin resistance in diabetes mice through promoting M2 macrophage polarization via activation of PPARγ.
  2. Molecular interactions of adaptor protein PSTPIP2 control neutrophil-mediated responses leading to autoinflammation.
    Title: Molecular interactions of adaptor protein PSTPIP2 control neutrophil-mediated responses leading to autoinflammation.
  3. PSTPIP2 regulates synovial macrophages polarization and dynamics via ERbeta in the joint microenvironment.
    Title: PSTPIP2 regulates synovial macrophages polarization and dynamics via ERβ in the joint microenvironment.
  4. Dysregulated NADPH Oxidase Promotes Bone Damage in Murine Model of Autoinflammatory Osteomyelitis.
    Title: Dysregulated NADPH Oxidase Promotes Bone Damage in Murine Model of Autoinflammatory Osteomyelitis.
  5. Knockdown of PSTPIP2 promoted M1 polarization and suppressed M2 polarization in vitro.
    Title: PSTPIP2 connects DNA methylation to macrophage polarization in CCL4-induced mouse model of hepatic fibrosis.
  6. a new PSTPIP1/PTPN6/SHIP1/2-dependent negative feedback mechanism that counterbalances Src and PI(3,4,5)P3 signalling to control osteoclast cell polarity and activity during bone resorption
    Title: BAR Proteins PSTPIP1/2 Regulate Podosome Dynamics and the Resorption Activity of Osteoclasts.
  7. SHIP1 and Csk are part of the PSTPIP2-dependent inhibitory network that prevents the development of autoinflammatory disease.
    Title: PSTPIP2, a Protein Associated with Autoinflammatory Disease, Interacts with Inhibitory Enzymes SHIP1 and Csk.
  8. PSTPIP2 could play a role in innate immunity and development of autoinflammatory bone disorders, and may be associated with the pathogenesis of SAPHO syndrome.
    Title: Increased neutrophil infiltration, IL-1 production and a SAPHO syndrome-like phenotype in PSTPIP2-deficient mice.
  9. IL-1beta has a role in mediating autoinflammatory disease in Pstpip2-deficient mice
    Title: Inflammasome-independent IL-1β mediates autoinflammatory disease in Pstpip2-deficient mice.
  10. inflammasome-independent production of IL-1beta has a critical role in osteolytic bone disease; PSTPIP2 is a negative regulator of caspase-1-autonomous IL-1beta production
    Title: Critical role for inflammasome-independent IL-1β production in osteomyelitis.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Associated conditions

Description Tests
chronic multifocal osteomyelitis
GeneReviews: Not available

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoskeleton organization NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
proline-serine-threonine phosphatase-interacting protein 2
Names
PEST phosphatase-interacting protein 2
macrophage actin-associated tyrosine-phosphorylated protein
pp37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013831.4 → NP_038859.3  proline-serine-threonine phosphatase-interacting protein 2

    See identical proteins and their annotated locations for NP_038859.3

    Status: VALIDATED

    Source sequence(s)
    AC157649, AK132418, AK157994, BY194204
    Consensus CDS
    CCDS37868.1
    UniProtKB/Swiss-Prot
    Q6GTF6, Q99M15, Q9Z189
    UniProtKB/TrEMBL
    Q3U4E4
    Related
    ENSMUSP00000110389.3, ENSMUST00000114741.4
    Conserved Domains (1) summary
    cd07672
    Location:15 → 254
    F-BAR_PSTPIP2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    77882250..77971462
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161032.1 → XP_036016925.1  proline-serine-threonine phosphatase-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6GTF6, Q99M15, Q9Z189
    UniProtKB/TrEMBL
    Q3U4E4
    Conserved Domains (1) summary
    cd07672
    Location:15 → 254
    F-BAR_PSTPIP2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 2

  2. XM_036161033.1 → XP_036016926.1  proline-serine-threonine phosphatase-interacting protein 2 isoform X2

    Conserved Domains (1) summary
    cl12013
    Location:15 → 247
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  3. XM_036161034.1 → XP_036016927.1  proline-serine-threonine phosphatase-interacting protein 2 isoform X3

    Conserved Domains (1) summary
    cd07672
    Location:15 → 247
    F-BAR_PSTPIP2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 2

  4. XM_036161035.1 → XP_036016928.1  proline-serine-threonine phosphatase-interacting protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A494BAM6
    Related
    ENSMUSP00000158158.2, ENSMUST00000238172.2
    Conserved Domains (1) summary
    cl12013
    Location:1 → 150
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177831.2: Suppressed sequence

    Description
    NM_177831.2: This RefSeq was suppressed because it overlaps with, and potentially represents a 5' extension of, NM_013831.3 of the Pstpip2 gene.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99M15.4 GenPept UniProtKB/Swiss-Prot:Q99M15

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