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Pstpip1 proline-serine-threonine phosphatase-interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 19200, updated on 11-Apr-2024

Summary

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Official Symbol
Pstpip1provided by MGI
Official Full Name
proline-serine-threonine phosphatase-interacting protein 1provided by MGI
Primary source
MGI:MGI:1321396
See related
Ensembl:ENSMUSG00000032322 AllianceGenome:MGI:1321396
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
def-2; CD2BP1
Summary
Enables actin binding activity and protein phosphatase binding activity. Predicted to be involved in actin filament polymerization. Predicted to act upstream of or within several processes, including endocytosis; inflammatory response; and innate immune response. Located in actomyosin contractile ring; cleavage furrow; and stress fiber. Is expressed in several structures, including genitourinary system; lung; musculature; pancreas; and spleen. Human ortholog(s) of this gene implicated in PAPA syndrome. Orthologous to human PSTPIP1 (proline-serine-threonine phosphatase interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 36.1), spleen adult (RPKM 16.1) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Pstpip1 in Genome Data Viewer
Location:
9 B; 9 30.13 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (55985729..56036174)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (56078445..56128890)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24198 Neighboring gene STARR-positive B cell enhancer mm9_chr9:55889495-55889796 Neighboring gene ring finger protein 19A pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr9:55923089-55923390 Neighboring gene reticulocalbin 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:55937639-55937826 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:55938770-55938923 Neighboring gene STARR-positive B cell enhancer ABC_E10547 Neighboring gene STARR-seq mESC enhancer starr_24202 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:55994441-55994594 Neighboring gene STARR-positive B cell enhancer ABC_E6737 Neighboring gene tetraspanin 3 Neighboring gene pseudopodium-enriched atypical kinase 1 Neighboring gene STARR-positive B cell enhancer mm9_chr9:56112222-56112523 Neighboring gene pseudopodium-enriched atypical kinase 1, opposite strand

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. BAR Proteins PSTPIP1/2 Regulate Podosome Dynamics and the Resorption Activity of Osteoclasts. Sztacho M, et al. PLoS One, 2016. PMID 27760174, Free PMC Article
  2. The PCH family member proline-serine-threonine phosphatase-interacting protein 1 targets to the leukocyte uropod and regulates directed cell migration. Cooper KM, et al. Mol Biol Cell, 2008 Aug. PMID 18480402, Free PMC Article
  3. Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins. Wang D, et al. J Biol Chem, 2013 Feb 15. PMID 23293022, Free PMC Article
  4. CD2BP1 modulates CD2-dependent T cell activation via linkage to protein tyrosine phosphatase (PTP)-PEST. Yang H, et al. J Immunol, 2006 May 15. PMID 16670297
  5. Tyrosine phosphorylation regulates the SH3-mediated binding of the Wiskott-Aldrich syndrome protein to PSTPIP, a cytoskeletal-associated protein. Wu Y, et al. J Biol Chem, 1998 Mar 6. PMID 9488710

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a new PSTPIP1/PTPN6/SHIP1/2-dependent negative feedback mechanism that counterbalances Src and PI(3,4,5)P3 signalling to control osteoclast cell polarity and activity during bone resorption
    Title: BAR Proteins PSTPIP1/2 Regulate Podosome Dynamics and the Resorption Activity of Osteoclasts.
  2. analysis of inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins
    Title: Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins.
  3. PSTPIP1 is a novel component of the leukocyte uropod that regulates endocytosis and cell migration
    Title: The PCH family member proline-serine-threonine phosphatase-interacting protein 1 targets to the leukocyte uropod and regulates directed cell migration.
  4. the intracellular Fas ligand (FasL) domain binding to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL
    Title: Binding of the intracellular Fas ligand (FasL) domain to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cytokinesis IC
Inferred by Curator
more info
 PubMed 
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actomyosin contractile ring IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cleavage furrow IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in stress fiber IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
proline-serine-threonine phosphatase-interacting protein 1
Names
PEST phosphatase-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001409150.1 → NP_001396079.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC158999

  2. NM_001409151.1 → NP_001396080.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC158999

  3. NM_001409152.1 → NP_001396081.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC158999

  4. NM_001409153.1 → NP_001396082.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC158999

  5. NM_001409154.1 → NP_001396083.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC158999

  6. NM_001409155.1 → NP_001396084.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC158999

  7. NM_001409156.1 → NP_001396085.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC158999

  8. NM_001409157.1 → NP_001396086.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC158999

  9. NM_001409158.1 → NP_001396087.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC158999

  10. NM_001409159.1 → NP_001396088.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC158999

  11. NM_001409160.1 → NP_001396089.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC158999

  12. NM_001409161.1 → NP_001396090.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC158999

  13. NM_011193.3 → NP_035323.2  proline-serine-threonine phosphatase-interacting protein 1 isoform 1

    See identical proteins and their annotated locations for NP_035323.2

    Status: VALIDATED

    Source sequence(s)
    AC158999
    Consensus CDS
    CCDS40645.1
    UniProtKB/Swiss-Prot
    P97814, Q4V9R4
    UniProtKB/TrEMBL
    A0A0R4J0P5
    Related
    ENSMUSP00000055823.8, ENSMUST00000059206.8
    Conserved Domains (2) summary
    cd11824
    Location:362 → 414
    SH3_PSTPIP1; Src homology 3 domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 1
    cl12013
    Location:16 → 257
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    55985729..56036174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242677.3 → XP_011240979.1  proline-serine-threonine phosphatase-interacting protein 1 isoform X3

    UniProtKB/Swiss-Prot
    P97814, Q4V9R4
    Conserved Domains (2) summary
    cd11824
    Location:351 → 403
    SH3_PSTPIP1; Src homology 3 domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 1
    cl12013
    Location:5 → 246
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. XM_006510865.3 → XP_006510928.1  proline-serine-threonine phosphatase-interacting protein 1 isoform X1

    UniProtKB/Swiss-Prot
    P97814, Q4V9R4
    Conserved Domains (2) summary
    cd07671
    Location:35 → 276
    F-BAR_PSTPIP1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 1
    cd11824
    Location:381 → 433
    SH3_PSTPIP1; Src homology 3 domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 1

RNA

  1. XR_004935348.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97814.1 GenPept UniProtKB/Swiss-Prot:P97814

Gene LinkOut

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