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Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 [ Mus musculus (house mouse) ]

Gene ID: 19185, updated on 11-Apr-2024

Summary

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Official Symbol
Psmd4provided by MGI
Official Full Name
proteasome (prosome, macropain) 26S subunit, non-ATPase, 4provided by MGI
Primary source
MGI:MGI:1201670
See related
Ensembl:ENSMUSG00000005625 AllianceGenome:MGI:1201670
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Af1; Mcb1; angiocidin
Summary
Predicted to enable identical protein binding activity and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome accessory complex. Is expressed in brain and surface ectoderm. Orthologous to human PSMD4 (proteasome 26S subunit ubiquitin receptor, non-ATPase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 83.0), placenta adult (RPKM 82.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F2.1; 3 40.74 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (94939999..94949880, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95032688..95042614, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol 4-kinase beta Neighboring gene zinc finger protein 687 Neighboring gene microRNA 7013 Neighboring gene RIKEN cDNA 4930481B07 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:94820548-94820749 Neighboring gene STARR-positive B cell enhancer ABC_E4560 Neighboring gene STARR-seq mESC enhancer starr_08364 Neighboring gene phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha Neighboring gene STARR-seq mESC enhancer starr_08366 Neighboring gene predicted gene, 24920 Neighboring gene predicted gene, 40095

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Brain Mitochondrial Subproteome of Rpn10-Binding Proteins and Its Changes Induced by the Neurotoxin MPTP and the Neuroprotector Isatin. Medvedev AE, et al. Biochemistry (Mosc), 2017 Mar. PMID 28320274
  2. Molecular cloning and testicular expression of the gene transcripts encoding the murine multiubiquitin-chain-binding protein (Mcb1). Pusch W, et al. Gene, 1998 Jan 19. PMID 9511739
  3. Developmentally regulated, alternative splicing of the Rpn10 gene generates multiple forms of 26S proteasomes. Kawahara H, et al. EMBO J, 2000 Aug 1. PMID 10921894, Free PMC Article
  4. Targeted disruption of neuronal 19S proteasome subunits induces the formation of ubiquitinated inclusions in the absence of cell death. Droggiti A, et al. J Neurochem, 2011 Nov. PMID 21883213
  5. Integrin alpha2beta1 mediates the anti-angiogenic and anti-tumor activities of angiocidin, a novel tumor-associated protein. Sabherwal Y, et al. Exp Cell Res, 2006 Aug 1. PMID 16762342

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the neuroprotective dose of isatin used in this study can result in brain isatin concentrations that are proapoptotic for cells in vitro, the altered repertoire of mitochondrial Rpn10-binding proteins may thus represent a part of a switch mechanism from targeted elimination of individual (damaged) proteins to more efficient ("global") elimination of damaged organelles and whole damaged cells.
    Title: Brain Mitochondrial Subproteome of Rpn10-Binding Proteins and Its Changes Induced by the Neurotoxin MPTP and the Neuroprotector Isatin.
  2. this study showed that Rpn13 plays a redundant role with Rpn10 in recognition and degradation of ubiquitinated proteins in mouse livers.
    Title: Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis.
  3. Results demonstrate that Rpn10-mediated degradation of ubiquitinated proteins, catalyzed by ubiquitin-interacting motifs, is indispensable for mammalian life.
    Title: Rpn10-mediated degradation of ubiquitinated proteins is essential for mouse development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome accessory complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome regulatory particle, base subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
26S proteasome non-ATPase regulatory subunit 4
Names
26S proteasome regulatory subunit RPN10
26S proteasome regulatory subunit S5A
RPN10 homolog
anti secretory factor 1
multiubiquitin chain-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282017.2 → NP_001268946.1  26S proteasome non-ATPase regulatory subunit 4 isoform 1

    See identical proteins and their annotated locations for NP_001268946.1

    Status: VALIDATED

    Source sequence(s)
    AC087062
    Consensus CDS
    CCDS71287.1
    UniProtKB/TrEMBL
    Q3ULG4, Q9CY29
    Related
    ENSMUSP00000071589.6, ENSMUST00000071664.12
    Conserved Domains (1) summary
    cd01452
    Location:1 → 187
    VWA_26S_proteasome_subunit; 26S proteasome plays a major role in eukaryotic protein breakdown, especially for ubiquitin-tagged proteins. It is an ATP-dependent protease responsible for the bulk of non-lysosomal proteolysis in eukaryotes, often using covalent modification of ...

  2. NM_001410538.1 → NP_001397467.1  26S proteasome non-ATPase regulatory subunit 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC087062

  3. NM_001410539.1 → NP_001397468.1  26S proteasome non-ATPase regulatory subunit 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC087062

  4. NM_001410540.1 → NP_001397469.1  26S proteasome non-ATPase regulatory subunit 4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC087062

  5. NM_001410541.1 → NP_001397470.1  26S proteasome non-ATPase regulatory subunit 4 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC087062

  6. NM_001410542.1 → NP_001397471.1  26S proteasome non-ATPase regulatory subunit 4 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC087062

  7. NM_001410543.1 → NP_001397472.1  26S proteasome non-ATPase regulatory subunit 4 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC087062

  8. NM_008951.3 → NP_032977.1  26S proteasome non-ATPase regulatory subunit 4 isoform 2

    See identical proteins and their annotated locations for NP_032977.1

    Status: VALIDATED

    Source sequence(s)
    AC087062
    Consensus CDS
    CCDS38541.1
    UniProtKB/Swiss-Prot
    O35226, Q91V59, Q9JJM0, Q9JJM1, Q9JJM2, Q9JJM3
    UniProtKB/TrEMBL
    Q9CY29
    Related
    ENSMUSP00000102857.2, ENSMUST00000107237.8
    Conserved Domains (1) summary
    cd01452
    Location:1 → 187
    VWA_26S_proteasome_subunit; 26S proteasome plays a major role in eukaryotic protein breakdown, especially for ubiquitin-tagged proteins. It is an ATP-dependent protease responsible for the bulk of non-lysosomal proteolysis in eukaryotes, often using covalent modification of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    94939999..94949880 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252465.1 → XP_030108325.1  26S proteasome non-ATPase regulatory subunit 4 isoform X2

    Conserved Domains (2) summary
    NF033415
    Location:202 → 257
    thiovirid_RiPP; thioviridamide family RiPP peptide
    cl00057
    Location:1 → 81
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  2. XM_006501137.3 → XP_006501200.1  26S proteasome non-ATPase regulatory subunit 4 isoform X1

    Conserved Domains (2) summary
    NF033415
    Location:205 → 260
    thiovirid_RiPP; thioviridamide family RiPP peptide
    cl00057
    Location:1 → 81
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35226.1 GenPept UniProtKB/Swiss-Prot:O35226

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