U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Psmc3ip proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein [ Mus musculus (house mouse) ]

Gene ID: 19183, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Psmc3ipprovided by MGI
Official Full Name
proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting proteinprovided by MGI
Primary source
MGI:MGI:1098610
See related
Ensembl:ENSMUSG00000019303 AllianceGenome:MGI:1098610
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HOP2; GT198; Tbpip
Summary
Predicted to enable several functions, including DNA binding domain binding activity; nuclear receptor binding activity; and nuclear receptor coactivator activity. Predicted to be involved in meiosis I and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within DNA recombination and meiotic cell cycle. Predicted to be located in nucleoplasm. Predicted to be part of DNA recombinase auxiliary factor complex. Predicted to be active in condensed nuclear chromosome. Is expressed in metanephros; submandibular gland primordium; telencephalon ventricular layer; tooth; and vibrissa. Human ortholog(s) of this gene implicated in ovarian dysgenesis 3. Orthologous to human PSMC3IP (PSMC3 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 36.1), CNS E11.5 (RPKM 17.1) and 11 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
11 D; 11 64.19 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100981238..100986261, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101092141..101095435, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene hydroxysteroid (17-beta) dehydrogenase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:100943626-100943809 Neighboring gene STARR-positive B cell enhancer ABC_E7065 Neighboring gene Coenzyme A synthase Neighboring gene MAX-like protein X Neighboring gene STARR-positive B cell enhancer ABC_E11773 Neighboring gene reticulophagy regulator family member 3 Neighboring gene STARR-positive B cell enhancer ABC_E4001 Neighboring gene STARR-positive B cell enhancer ABC_E1843 Neighboring gene tubulin, gamma 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Solution structure and DNA-binding properties of the winged helix domain of the meiotic recombination HOP2 protein. Moktan H, et al. J Biol Chem, 2014 May 23. PMID 24711446, Free PMC Article
  2. The Hop2 protein has a direct role in promoting interhomolog interactions during mouse meiosis. Petukhova GV, et al. Dev Cell, 2003 Dec. PMID 14667414
  3. Hop2 interacts with the transcription factor CEBPα and suppresses adipocyte differentiation. Lin T, et al. J Biol Chem, 2021 Nov. PMID 34600885, Free PMC Article
  4. Hop2 Interacts with ATF4 to Promote Osteoblast Differentiation. Zhang Y, et al. J Bone Miner Res, 2019 Dec. PMID 31433867, Free PMC Article
  5. The dual role of HOP2 in mammalian meiotic homologous recombination. Pezza RJ, et al. Nucleic Acids Res, 2014 Feb. PMID 24304900, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hop2 interacts with the transcription factor CEBPalpha and suppresses adipocyte differentiation.
    Title: Hop2 interacts with the transcription factor CEBPα and suppresses adipocyte differentiation.
  2. Hop2 Interacts with ATF4 to Promote Osteoblast Differentiation.
    Title: Hop2 Interacts with ATF4 to Promote Osteoblast Differentiation.
  3. HOP2-MND1 enhances the interaction of RAD51 with nucleotide cofactors and modifies its DNA-binding specificity.
    Title: HOP2-MND1 modulates RAD51 binding to nucleotides and DNA.
  4. Results show the role of a coiled-coil structural feature involved in HOP2 self-association.
    Title: Solution structure and DNA-binding properties of the winged helix domain of the meiotic recombination HOP2 protein.
  5. Authors propose that HOP2 may act as a recombinase with specific functions in meiosis.
    Title: The dual role of HOP2 in mammalian meiotic homologous recombination.
  6. Hop2/Mnd1 greatly stimulates Dmc1 to promote synaptic complex formation on long duplex DNAs
    Title: Hop2/Mnd1 acts on two critical steps in Dmc1-promoted homologous pairing.
  7. C-terminal basic region of TBPIP/HOP2 is required for efficient DNA binding and is also essential for its homologous pairing stimulation activity
    Title: Positive role of the mammalian TBPIP/HOP2 protein in DMC1-mediated homologous pairing.
  8. data reveal an interplay among Hop2, Mnd1 and Rad51 and Dmc1 in the formation of the first recombination intermediates during meiosis
    Title: The Hop2 and Mnd1 proteins act in concert with Rad51 and Dmc1 in meiotic recombination.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding domain binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear androgen receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear glucocorticoid receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables nuclear thyroid hormone receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables recombinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in homologous chromosome pairing at meiosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homologous chromosome pairing at meiosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic joint molecule formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic strand invasion involved in reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in reciprocal meiotic recombination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of DNA recombinase auxiliary factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in condensed nuclear chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
homologous-pairing protein 2 homolog
Names
PSMC3-interacting protein
TBP-1-interacting protein
proteasome 26S ATPase subunit 3-interacting protein
tat-binding protein 1-interacting protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008949.3 → NP_032975.1  homologous-pairing protein 2 homolog

    See identical proteins and their annotated locations for NP_032975.1

    Status: VALIDATED

    Source sequence(s)
    AK133462, BF658859, BX255926
    Consensus CDS
    CCDS25448.1
    UniProtKB/Swiss-Prot
    O35047, Q3V035
    UniProtKB/TrEMBL
    C4PFH5
    Related
    ENSMUSP00000019447.9, ENSMUST00000019447.15
    Conserved Domains (1) summary
    pfam07106
    Location:16 → 179
    TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    100981238..100986261 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245675.2 → XP_030101535.1  homologous-pairing protein 2 homolog isoform X1

    UniProtKB/TrEMBL
    C4PFH6
    Conserved Domains (1) summary
    pfam18517
    Location:45 → 100
    LZ3wCH; Leucine zipper with capping helix domain

  2. XM_006532524.4 → XP_006532587.1  homologous-pairing protein 2 homolog isoform X1

    See identical proteins and their annotated locations for XP_006532587.1

    UniProtKB/TrEMBL
    C4PFH6
    Conserved Domains (1) summary
    pfam18517
    Location:45 → 100
    LZ3wCH; Leucine zipper with capping helix domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35047.1 GenPept UniProtKB/Swiss-Prot:O35047

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous