U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nme1 NME/NM23 nucleoside diphosphate kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 191575, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Nme1provided by RGD
Official Full Name
NME/NM23 nucleoside diphosphate kinase 1provided by RGD
Primary source
RGD:70497
See related
Ensembl:ENSRNOG00000002693 AllianceGenome:RGD:70497
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables several functions, including DNA binding activity; gamma-tubulin binding activity; and nucleoside diphosphate kinase activity. Involved in several processes, including cellular response to glucose stimulus; response to cAMP; and response to testosterone. Located in several cellular components, including centrosome; mitochondrial outer membrane; and perinuclear region of cytoplasm. Colocalizes with intermediate filament. Human ortholog(s) of this gene implicated in neuroblastoma; ovary epithelial cancer; and teratoma. Orthologous to human NME1 (NME/NM23 nucleoside diphosphate kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 449.2), Thymus (RPKM 294.5) and 9 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
10q26
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (79403939..79426620, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (78907036..78929659, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (81657152..81666542, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene UTP18 small subunit processome component Neighboring gene mbt domain containing 1 Neighboring gene NME/NM23 nucleoside diphosphate kinase 2 Neighboring gene endogenous Bornavirus like nucleoprotein 1 Neighboring gene sperm associated antigen 9

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Erythropoietin increases neuronal NDPKA expression, and NDPKA up-regulation as well as exogenous application protects cortical neurons from in vitro ischemia-related insults. Teoh J, et al. Cell Mol Neurobiol, 2014 Apr. PMID 24395206
  2. Proteomics of rat prostate lobes treated with 2-N-hydroxylamino-1-methyl-6-phenylimidazo[4,5-b]pyridine, 5alpha-dihydrotestosterone, individually and in combination. Boyiri T, et al. Int J Oncol, 2009 Sep. PMID 19639176, Free PMC Article
  3. Proteome analysis of human pancreatic ductal adenocarcinoma tissue using two-dimensional gel electrophoresis and tandem mass spectrometry for identification of disease-related proteins. Tian R, et al. Dig Dis Sci, 2008 Jan. PMID 17492507
  4. Plasma membrane-associated nucleoside diphosphate kinase (nm23) in the heart is regulated by beta-adrenergic signaling. Lutz S, et al. Br J Pharmacol, 2003 Nov. PMID 14559858, Free PMC Article
  5. Identification of the tumor metastasis suppressor Nm23-H1/Nm23-R1 as a constituent of the centrosome. Roymans D, et al. Exp Cell Res, 2001 Jan 15. PMID 11139339

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation of metastasis suppressor NME1 by a key metabolic cofactor coenzyme A.
    Title: Regulation of metastasis suppressor NME1 by a key metabolic cofactor coenzyme A.
  2. NDPKA up-regulation increased neuronal survival in cortical neurons from cerebral ischemia models.
    Title: Erythropoietin increases neuronal NDPKA expression, and NDPKA up-regulation as well as exogenous application protects cortical neurons from in vitro ischemia-related insults.
  3. data suggested that NME1 acts as a switcher or reprogramming factor which involves in oligodentrocyte versus neuron cell fate specification in vitro
    Title: Nucleoside diphosphate kinase Nm23-M1 involves in oligodendroglial versus neuronal cell fate decision in vitro.
  4. Down-regulation of expression and function of Nme1 in insulin-secreting beta-cells under in vitro conditions of glucolipotoxicity is reported.
    Title: Down-regulation of expression and function of nucleoside diphosphate kinase in insulin-secreting beta-cells under in vitro conditions of glucolipotoxicity.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3'-5' exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA nuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables gamma-tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables intermediate filament binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleoside diphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleoside diphosphate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleoside diphosphate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside diphosphate kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
  
enables ribosomal small subunit binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in CTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GTP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in GTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in UTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to fatty acid IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to glucose stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in hippocampus development IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within lactation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mammary gland development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of myeloid leukocyte differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to amine IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to cAMP IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to testosterone IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in intermediate filament IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
nucleoside diphosphate kinase A
Names
NDK A
NDP kinase A
NDP kinase beta
expressed in non-metastatic cells 1, protein (NM23A) (nucleoside diphosphate kinase)
metastasis inhibition factor NM23
non-metastatic cells 1, protein (NM23A) expressed in
nucloside diphosphate kinase
tumor metastatic process-associated protein
NP_612557.1
XP_017452467.1
XP_017452468.1
XP_038941085.1
XP_038941086.1
XP_063124445.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138548.2 → NP_612557.1  nucleoside diphosphate kinase A

    See identical proteins and their annotated locations for NP_612557.1

    Status: PROVISIONAL

    Source sequence(s)
    D13374
    UniProtKB/Swiss-Prot
    Q05982
    UniProtKB/TrEMBL
    A6HI35
    Related
    ENSRNOP00000083790.1, ENSRNOT00000112785.1
    Conserved Domains (1) summary
    PTZ00093
    Location:3 → 151
    PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    79403939..79426620 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085157.2 → XP_038941085.1  nucleoside diphosphate kinase A isoform X1

    UniProtKB/Swiss-Prot
    Q05982
    UniProtKB/TrEMBL
    A6HI35
    Conserved Domains (1) summary
    PTZ00093
    Location:3 → 151
    PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional

  2. XM_063268375.1 → XP_063124445.1  nucleoside diphosphate kinase A isoform X1

    UniProtKB/Swiss-Prot
    Q05982
    UniProtKB/TrEMBL
    A6HI35

  3. XM_039085158.2 → XP_038941086.1  nucleoside diphosphate kinase A isoform X1

    UniProtKB/Swiss-Prot
    Q05982
    UniProtKB/TrEMBL
    A6HI35
    Conserved Domains (1) summary
    PTZ00093
    Location:3 → 151
    PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional

  4. XM_017596978.3 → XP_017452467.1  nucleoside diphosphate kinase A isoform X1

    UniProtKB/Swiss-Prot
    Q05982
    UniProtKB/TrEMBL
    A6HI35
    Conserved Domains (1) summary
    PTZ00093
    Location:3 → 151
    PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional

  5. XM_017596979.3 → XP_017452468.1  nucleoside diphosphate kinase A isoform X1

    UniProtKB/Swiss-Prot
    Q05982
    UniProtKB/TrEMBL
    A6HI35
    Conserved Domains (1) summary
    PTZ00093
    Location:3 → 151
    PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05982.1 GenPept UniProtKB/Swiss-Prot:Q05982

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous