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Npepps aminopeptidase puromycin sensitive [ Mus musculus (house mouse) ]

Gene ID: 19155, updated on 11-Apr-2024

Summary

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Official Symbol
Npeppsprovided by MGI
Official Full Name
aminopeptidase puromycin sensitiveprovided by MGI
Primary source
MGI:MGI:1101358
See related
Ensembl:ENSMUSG00000001441 AllianceGenome:MGI:1101358
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Psa; goku; AAP-S; MP100
Summary
Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in cellular response to hypoxia; peptide catabolic process; and proteolysis. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; ear; genitourinary system; and integumental system. Orthologous to human NPEPPS (aminopeptidase puromycin sensitive). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 20.8), CNS E14 (RPKM 19.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 D; 11 60.95 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97096668..97171503, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97205842..97280660, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8447 Neighboring gene TBK1 binding protein 1 Neighboring gene microRNA 7235 Neighboring gene karyopherin subunit beta 1 Neighboring gene STARR-positive B cell enhancer ABC_E1842 Neighboring gene STARR-positive B cell enhancer ABC_E910 Neighboring gene predicted gene 11592 Neighboring gene STARR-seq mESC enhancer starr_30592 Neighboring gene STARR-seq mESC enhancer starr_30593 Neighboring gene predicted gene, 31005 Neighboring gene STARR-seq mESC enhancer starr_30594 Neighboring gene mitochondrial ribosomal protein L45

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Puromycin-sensitive aminopeptidase limits MHC class I presentation in dendritic cells but does not affect CD8 T cell responses during viral infections. Towne CF, et al. J Immunol, 2008 Feb 1. PMID 18209067
  2. Male reproductive defects caused by puromycin-sensitive aminopeptidase deficiency in mice. Osada T, et al. Mol Endocrinol, 2001 Jun. PMID 11376114
  3. Puromycin-sensitive aminopeptidase is essential for the maternal recognition of pregnancy in mice. Osada T, et al. Mol Endocrinol, 2001 Jun. PMID 11376108
  4. Increased anxiety and impaired pain response in puromycin-sensitive aminopeptidase gene-deficient mice obtained by a mouse gene-trap method. Osada T, et al. J Neurosci, 1999 Jul 15. PMID 10407043, Free PMC Article
  5. PSA controls hepatic lipid metabolism by regulating the NRF2 signaling pathway. Huang B, et al. J Mol Cell Biol, 2021 Oct 21. PMID 34048566, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PSA controls hepatic lipid metabolism by regulating the NRF2 signaling pathway.
    Title: PSA controls hepatic lipid metabolism by regulating the NRF2 signaling pathway.
  2. Nucleocytoplasmic transfer of cyclin dependent kinase 5 and its binding to puromycin-sensitive aminopeptidase in Dictyostelium discoideum
    Title: Nucleocytoplasmic transfer of cyclin dependent kinase 5 and its binding to puromycin-sensitive aminopeptidase in Dictyostelium discoideum.
  3. findings show that by promoting autophagic protein clearance, PSA helps protect against accumulation of aggregation-prone proteins and proteotoxicity
    Title: Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy.
  4. These data indicate that PSA may play a role in limiting MHC class I Ag presentation in dendritic cells in vivo but that it is not essential for generating most MHC class I-presented peptides or for stimulating CTL responses to several Ags.
    Title: Puromycin-sensitive aminopeptidase limits MHC class I presentation in dendritic cells but does not affect CD8 T cell responses during viral infections.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC102199

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aminopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloaminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
involved_in peptide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
puromycin-sensitive aminopeptidase
Names
cytosol alanyl aminopeptidase
NP_032968.2
XP_011247104.1
XP_030101528.1
XP_030101529.1
XP_030101530.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008942.3 → NP_032968.2  puromycin-sensitive aminopeptidase

    See identical proteins and their annotated locations for NP_032968.2

    Status: VALIDATED

    Source sequence(s)
    AI839456, BC098212
    Consensus CDS
    CCDS25317.1
    UniProtKB/Swiss-Prot
    Q11011, Q3UZE0, Q5PR74, Q91VJ8
    UniProtKB/TrEMBL
    F6QYF8
    Related
    ENSMUSP00000001480.8, ENSMUST00000001480.14
    Conserved Domains (3) summary
    cd09601
    Location:62 → 505
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam01433
    Location:54 → 442
    Peptidase_M1; Peptidase family M1
    pfam11838
    Location:580 → 891
    ERAP1_C; ERAP1-like C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    97096668..97171503 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245670.1 → XP_030101530.1  puromycin-sensitive aminopeptidase isoform X2

    Conserved Domains (3) summary
    TIGR02414
    Location:1 → 128
    pepN_proteo; aminopeptidase N, Escherichia coli type
    pfam01433
    Location:1 → 51
    Peptidase_M1; Peptidase family M1 domain
    pfam11838
    Location:132 → 445
    ERAP1_C; ERAP1-like C-terminal domain

  2. XM_030245668.2 → XP_030101528.1  puromycin-sensitive aminopeptidase isoform X1

    UniProtKB/TrEMBL
    F6QYF8
    Conserved Domains (2) summary
    cd09601
    Location:1 → 344
    M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)
    pfam11838
    Location:423 → 736
    ERAP1_C; ERAP1-like C-terminal domain

  3. XM_011248802.2 → XP_011247104.1  puromycin-sensitive aminopeptidase isoform X1

    See identical proteins and their annotated locations for XP_011247104.1

    UniProtKB/TrEMBL
    F6QYF8
    Conserved Domains (2) summary
    cd09601
    Location:1 → 344
    M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)
    pfam11838
    Location:423 → 736
    ERAP1_C; ERAP1-like C-terminal domain

  4. XM_030245669.2 → XP_030101529.1  puromycin-sensitive aminopeptidase isoform X1

    UniProtKB/TrEMBL
    F6QYF8
    Conserved Domains (2) summary
    cd09601
    Location:1 → 344
    M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)
    pfam11838
    Location:423 → 736
    ERAP1_C; ERAP1-like C-terminal domain

RNA

  1. XR_879535.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q11011.2 GenPept UniProtKB/Swiss-Prot:Q11011

Gene LinkOut

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