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Prpf4b pre-mRNA processing factor 4B [ Mus musculus (house mouse) ]

Gene ID: 19134, updated on 11-Apr-2024

Summary

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Official Symbol
Prpf4bprovided by MGI
Official Full Name
pre-mRNA processing factor 4Bprovided by MGI
Primary source
MGI:MGI:109584
See related
Ensembl:ENSMUSG00000021413 AllianceGenome:MGI:109584
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Prp4; Prpk; Prp4k; cbp143; 2610037H07
Summary
Predicted to enable protein kinase activity. Predicted to be involved in protein phosphorylation. Predicted to act upstream of or within RNA splicing; mRNA processing; and phosphorylation. Located in chromosome. Is expressed in several structures, including early conceptus; oocyte; and pancreas epithelium. Orthologous to human PRPF4B (pre-mRNA processing factor 4B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 19.1), limb E14.5 (RPKM 16.8) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Prpf4b in Genome Data Viewer
Location:
13 A3.3; 13 14.21 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (35058803..35090047)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (34874820..34906064)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 50, member B Neighboring gene STARR-positive B cell enhancer ABC_E4064 Neighboring gene VISTA enhancer mm180 Neighboring gene STARR-positive B cell enhancer ABC_E11539 Neighboring gene STARR-positive B cell enhancer ABC_E7222 Neighboring gene STARR-positive B cell enhancer ABC_E7223 Neighboring gene ribosomal protein S4, X-linked pseudogene Neighboring gene predicted gene, 36839 Neighboring gene STARR-seq mESC enhancer starr_34164 Neighboring gene family with sequence similarity 217, member A Neighboring gene testis expressed 56 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional analysis of the fission yeast Prp4 protein kinase involved in pre-mRNA splicing and isolation of a putative mammalian homologue. Gross T, et al. Nucleic Acids Res, 1997 Mar 1. PMID 9102632, Free PMC Article
  2. Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes. Dellaire G, et al. Mol Cell Biol, 2002 Jul. PMID 12077342, Free PMC Article
  3. Cloning of human PRP4 reveals interaction with Clk1. Kojima T, et al. J Biol Chem, 2001 Aug 24. PMID 11418604
  4. Capturing novel mouse genes encoding chromosomal and other nuclear proteins. Tate P, et al. J Cell Sci, 1998 Sep. PMID 9701556
  5. Analysis of Presenilin 1 and 2 interacting proteins in mouse cerebral cortex during development. Kumar A, et al. Int J Dev Neurosci, 2014 Nov. PMID 25196998

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes.
    Title: Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (5) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC5960

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA cis splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic cell cycle spindle assembly checkpoint ISO
Inferred from Sequence Orthology
more info
  
involved_in spliceosomal snRNP assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in spliceosomal tri-snRNP complex assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase PRP4 homolog
Names
PRP4 pre-mRNA processing factor 4 homolog B
PRP4 pre-mRNA-processing factor 4 homolog
pre-mRNA protein kinase
NP_038858.2
XP_006516645.1
XP_006516647.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013830.3 → NP_038858.2  serine/threonine-protein kinase PRP4 homolog

    See identical proteins and their annotated locations for NP_038858.2

    Status: VALIDATED

    Source sequence(s)
    AC124537, AC132344
    Consensus CDS
    CCDS26448.1
    UniProtKB/Swiss-Prot
    B2RUN6, O88378, Q61136, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0
    UniProtKB/TrEMBL
    C7G3P2
    Related
    ENSMUSP00000077019.4, ENSMUST00000077853.5
    Conserved Domains (2) summary
    PTZ00449
    Location:171 → 393
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd14135
    Location:686 → 1003
    STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4

RNA

  1. NR_165078.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC124537, AC132344

  2. NR_165079.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC124537, AC132344

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    35058803..35090047
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516584.4 → XP_006516647.1  serine/threonine-protein kinase PRP4 homolog isoform X2

    UniProtKB/TrEMBL
    C7G3P2
    Conserved Domains (2) summary
    PTZ00449
    Location:171 → 393
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cl21453
    Location:686 → 860
    PKc_like; Protein Kinases, catalytic domain

  2. XM_006516582.4 → XP_006516645.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/TrEMBL
    C7G3P2
    Conserved Domains (2) summary
    PTZ00449
    Location:171 → 393
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cl21453
    Location:686 → 860
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_004937977.1 RNA Sequence

  2. XR_004937978.1 RNA Sequence

  3. XR_004937979.1 RNA Sequence

  4. XR_004937980.1 RNA Sequence

  5. XR_004937976.1 RNA Sequence

  6. XR_004937974.1 RNA Sequence

  7. XR_004937975.1 RNA Sequence

  8. XR_004937968.1 RNA Sequence

  9. XR_004937969.1 RNA Sequence

  10. XR_004937970.1 RNA Sequence

  11. XR_004937971.1 RNA Sequence

  12. XR_004937972.1 RNA Sequence

  13. XR_004937973.1 RNA Sequence

  14. XR_004937966.1 RNA Sequence

  15. XR_004937967.1 RNA Sequence

  16. XR_004937946.1 RNA Sequence

  17. XR_004937950.1 RNA Sequence

  18. XR_004937956.1 RNA Sequence

  19. XR_004937945.1 RNA Sequence

  20. XR_004937949.1 RNA Sequence

  21. XR_004937954.1 RNA Sequence

  22. XR_004937958.1 RNA Sequence

  23. XR_004937952.1 RNA Sequence

  24. XR_004937953.1 RNA Sequence

  25. XR_004937947.1 RNA Sequence

  26. XR_004937955.1 RNA Sequence

  27. XR_004937962.1 RNA Sequence

  28. XR_004937948.1 RNA Sequence

  29. XR_004937951.1 RNA Sequence

  30. XR_004937957.1 RNA Sequence

  31. XR_004937960.1 RNA Sequence

  32. XR_004937959.1 RNA Sequence

  33. XR_004937961.1 RNA Sequence

  34. XR_004937963.1 RNA Sequence

  35. XR_004937964.1 RNA Sequence

  36. XR_004937965.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61136.3 GenPept UniProtKB/Swiss-Prot:Q61136

Gene LinkOut

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