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Procr protein C receptor, endothelial [ Mus musculus (house mouse) ]

Gene ID: 19124, updated on 21-Apr-2024

Summary

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Official Symbol
Procrprovided by MGI
Official Full Name
protein C receptor, endothelialprovided by MGI
Primary source
MGI:MGI:104596
See related
Ensembl:ENSMUSG00000027611 AllianceGenome:MGI:104596
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccca; Epcr; Ccd41
Summary
Predicted to enable protein C-terminus binding activity. Predicted to be involved in negative regulation of coagulation. Predicted to act upstream of or within blood coagulation. Located in centrosome. Is expressed in several structures, including blastocyst; endocardial tissue; female reproductive system; liver; and vascular element. Orthologous to human PROCR (protein C receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 44.4), bladder adult (RPKM 5.1) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H1; 2 77.26 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155592159..155597391)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (155751125..155755478)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily C, member 4 associated protein Neighboring gene predicted gene, 22334 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:155505379-155505532 Neighboring gene ER degradation enhancer, mannosidase alpha-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E10157 Neighboring gene STARR-seq mESC enhancer starr_06149 Neighboring gene matrix metallopeptidase 24 Neighboring gene predicted gene, 46772 Neighboring gene STARR-positive B cell enhancer ABC_E4512 Neighboring gene matrix metallopeptidase 24 opposite strand transcript 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Differential expression of endothelial protein C receptor (EPCR) in hematopoietic stem and multipotent progenitor cells in young and old mice. Lin DS, et al. Cells Dev, 2023 Jun. PMID 37080459
  2. Endothelial cell protein C receptor regulates neutrophil extracellular trap-mediated rheumatoid arthritis disease progression. Liu X, et al. Int Immunopharmacol, 2022 Nov. PMID 36152537
  3. Endothelial Cell Protein C Receptor Deficiency Attenuates Streptococcus pneumoniae-induced Pleural Fibrosis. Keshava S, et al. Am J Respir Cell Mol Biol, 2021 Apr. PMID 33600743, Free PMC Article
  4. Chromatin regulatory dynamics of early human small intestinal development using a directed differentiation model. Hung YH, et al. Nucleic Acids Res, 2021 Jan 25. PMID 33406262, Free PMC Article
  5. A critical role of endothelial cell protein C receptor in the intestinal homeostasis in experimental colitis. Kondreddy V, et al. Sci Rep, 2020 Nov 25. PMID 33239717, Free PMC Article

See all (90) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EPCR deficiency ameliorates inflammatory arthritis in mice by suppressing the activation and migration of T cells and dendritic cells.
    Title: EPCR deficiency ameliorates inflammatory arthritis in mice by suppressing the activation and migration of T cells and dendritic cells.
  2. Endothelial Protein C Receptor and 3K3A-Activated Protein C Protect Mice from Allergic Contact Dermatitis in a Contact Hypersensitivity Model.
    Title: Endothelial Protein C Receptor and 3K3A-Activated Protein C Protect Mice from Allergic Contact Dermatitis in a Contact Hypersensitivity Model.
  3. Differential expression of endothelial protein C receptor (EPCR) in hematopoietic stem and multipotent progenitor cells in young and old mice.
    Title: Differential expression of endothelial protein C receptor (EPCR) in hematopoietic stem and multipotent progenitor cells in young and old mice.
  4. Endothelial cell protein C receptor regulates neutrophil extracellular trap-mediated rheumatoid arthritis disease progression.
    Title: Endothelial cell protein C receptor regulates neutrophil extracellular trap-mediated rheumatoid arthritis disease progression.
  5. The endothelial protein C receptor plays an essential role in the maintenance of pregnancy.
    Title: The endothelial protein C receptor plays an essential role in the maintenance of pregnancy.
  6. Activated Protein C Strengthens Cardiac Tolerance to Ischemic Insults in Aging.
    Title: Activated Protein C Strengthens Cardiac Tolerance to Ischemic Insults in Aging.
  7. Endothelial Cell Protein C Receptor Deficiency Attenuates Streptococcus pneumoniae-induced Pleural Fibrosis.
    Title: Endothelial Cell Protein C Receptor Deficiency Attenuates Streptococcus pneumoniae-induced Pleural Fibrosis.
  8. Lipid presentation by the protein C receptor links coagulation with autoimmunity.
    Title: Lipid presentation by the protein C receptor links coagulation with autoimmunity.
  9. EPCR deficiency or function-blocking antibody protects against joint bleeding-induced pathology in hemophilia mice.
    Title: EPCR deficiency or function-blocking antibody protects against joint bleeding-induced pathology in hemophilia mice.
  10. Elevated levels of soluble Endothelial protein C receptor in rheumatoid arthritis and block the therapeutic effect of protein C in collagen-induced arthritis.
    Title: Elevated levels of soluble Endothelial protein C receptor in rheumatoid arthritis and block the therapeutic effect of protein C in collagen-induced arthritis.
Submit: New GeneRIF Correction See all GeneRIFs (47)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (11)  1 citation
  • Endonuclease-mediated (7) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blood coagulation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within hemostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of coagulation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of coagulation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of coagulation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
endothelial protein C receptor
Names
APC receptor
CD antigen CD201
activated protein C receptor
centrocyclin
centrosomal protein CCD41
endothelial cell protein C receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420719.1 → NP_001407648.1  endothelial protein C receptor isoform b

    Status: VALIDATED

    Source sequence(s)
    AL929233

  2. NM_001420720.1 → NP_001407649.1  endothelial protein C receptor isoform b

    Status: VALIDATED

    Source sequence(s)
    AL929233

  3. NM_011171.3 → NP_035301.2  endothelial protein C receptor isoform a precursor

    See identical proteins and their annotated locations for NP_035301.2

    Status: VALIDATED

    Source sequence(s)
    AL929233
    Consensus CDS
    CCDS16954.1
    UniProtKB/Swiss-Prot
    Q4FK76, Q64695, Q9WV33
    Related
    ENSMUSP00000029140.6, ENSMUST00000029140.12
    Conserved Domains (1) summary
    cl08246
    Location:21 → 194
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    155592159..155597391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498955.3 → XP_006499018.1  endothelial protein C receptor isoform X1

    See identical proteins and their annotated locations for XP_006499018.1

    UniProtKB/TrEMBL
    Q8K357
    Conserved Domains (1) summary
    cl08246
    Location:20 → 194
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64695.3 GenPept UniProtKB/Swiss-Prot:Q64695

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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