Prl6a1 prolactin family 6, subfamily a, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prl6a1provided by MGI
Official Full Name: prolactin family 6, subfamily a, member 1provided by MGI
Primary source: MGI:MGI:1206579
See related: Ensembl:ENSMUSG00000069259 AllianceGenome:MGI:1206579
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ghd10; PLP-B; Prlpb
Summary: Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including positive regulation of lactation; positive regulation of pri-miRNA transcription by RNA polymerase II; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in decidua; ectoplacental cone; extraembryonic component; and placenta. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PRL (prolactin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward placenta adult (RPKM 66.5) See more
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 13 A3.1; 13 12.39 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (27496598..27503237)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (27312615..27319254)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Prl6a1 (e-PCR), detects polymorphism
- UniSTS:525390

Prl6a1 (e-PCR), detects polymorphism
- UniSTS:525397

NoName (e-PCR)
- UniSTS:488309

NoName (e-PCR)
- UniSTS:495495

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables prolactin receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in female pregnancy	IBA Inferred from Biological aspect of Ancestor more info
involved_in mammary gland development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of lactation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to nutrient levels	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: prolactin-6A1

Names: PRL-like protein B; growth hormone d10; placental prolactin-like protein B; prolactin-like protein B

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001382844.1 → NP_001369773.1 prolactin-6A1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AL592443

UniProtKB/TrEMBL

Q5SXJ8

Conserved Domains (1) summary

cd10288
Location:29 → 229

prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones
NM_011166.2 → NP_035296.1 prolactin-6A1 isoform 1 precursor

See identical proteins and their annotated locations for NP_035296.1

Status: VALIDATED

Source sequence(s)

AF015563

Consensus CDS

CCDS26395.1

UniProtKB/Swiss-Prot

O35257

UniProtKB/TrEMBL

A0A0M6L0L9, Q5SXJ8

Related

ENSMUSP00000089269.3, ENSMUST00000091680.9

Conserved Domains (1) summary

cd10288
Location:30 → 230

prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones