Prg2 proteoglycan 2, bone marrow [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prg2provided by MGI
Official Full Name: proteoglycan 2, bone marrowprovided by MGI
Primary source: MGI:MGI:103294
See related: Ensembl:ENSMUSG00000027073 AllianceGenome:MGI:103294
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MBP; EMBP; mMBP; mMBP-1
Summary: Predicted to enable carbohydrate binding activity. Predicted to be an extracellular matrix structural constituent conferring compression resistance. Acts upstream of or within defense response to nematode; negative regulation of interleukin-10 production; and positive regulation of interleukin-4 production. Located in collagen-containing extracellular matrix. Is expressed in several structures, including immune system; liver; lung; and testis. Orthologous to human PRG2 (proteoglycan 2, pro eosinophil major basic protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E18 (RPKM 50.3), liver E14 (RPKM 38.1) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 D; 2 49.45 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (84810805..84813977)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (84980461..84983632)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches.
Title: The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches.
Study demonstrates, for the first time, a vesicular trafficking of MBP-1 within mouse eosinophils elicited by a Schistosoma mansoni helminth infection.
Title: Identification of Piecemeal Degranulation and Vesicular Transport of MBP-1 in Liver-Infiltrating Mouse Eosinophils During Acute Experimental Schistosoma mansoni Infection.
data show that bioactive phospholipids and PRG-2 are critical for guiding thalamic axons to their proper cortical targets.
Title: Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling.
The absence of MBP-1 and EPX promoted a concomitant loss of eosinophil lineage-committed progenitors in the marrow, identifying a specific blockade in eosinophilopoiesis as the causative event.
Title: Expression of the secondary granule proteins major basic protein 1 (MBP-1) and eosinophil peroxidase (EPX) is required for eosinophilopoiesis in mice.
Host protection against Brugia pahangi infections was unimpaired in mice deficient in major basic protein 1.
Title: Eosinophils, but not eosinophil peroxidase or major basic protein, are important for host protection in experimental Brugia pahangi infection.
Mice deficient for either eosinophil peroxidase or major basic protein on the 129/SvJ background developed significantly higher worm burdens than wild-type mice.(major basic protein 1)
Title: Lack of eosinophil peroxidase or major basic protein impairs defense against murine filarial infection.
Eosinophil-derived MBP-1 plays a significant role in regulating muscular dystrophy by attenuating the cellular immune response and promoting tissue fibrosis that can eventually contribute to increased mortality.
Title: Major basic protein-1 promotes fibrosis of dystrophic muscle and attenuates the cellular immune response in muscular dystrophy.
major basic protein decreases epithelial barrier function and in this manner contributes to the pathogenesis of inflammatory bowel diseases.
Title: Eosinophils alter colonic epithelial barrier function: role for major basic protein.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Prg2 (e-PCR), detects polymorphism
- UniSTS:164930

NoName (e-PCR)
- UniSTS:487660

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables extracellular matrix structural constituent conferring compression resistance	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to bacterium	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response to nematode	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of interleukin-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-4 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of macrophage cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of interleukin-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of macrophage cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-4 production	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: bone marrow proteoglycan

Names: BMPG; major basic protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008920.4 → NP_032946.1 bone marrow proteoglycan precursor

See identical proteins and their annotated locations for NP_032946.1

Status: PROVISIONAL

Source sequence(s)

AL935159

Consensus CDS

CCDS16198.1

UniProtKB/Swiss-Prot

Q61878

UniProtKB/TrEMBL

Q545D8

Related

ENSMUSP00000028467.6, ENSMUST00000028467.6

Conserved Domains (1) summary

cd03598
Location:107 → 223

CLECT_EMBP_like; C-type lectin-like domain (CTLD) of the type found in the human proteins, eosinophil major basic protein (EMBP) and prepro major basic protein homolog (MBPH)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

84810805..84813977

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159620.1 → XP_036015513.1 bone marrow proteoglycan isoform X1

UniProtKB/Swiss-Prot

Q61878

UniProtKB/TrEMBL

Q545D8

Conserved Domains (1) summary

cd03598
Location:107 → 223

CLECT_EMBP_like; C-type lectin-like domain (CTLD) of the type found in the human proteins, eosinophil major basic protein (EMBP) and prepro major basic protein homolog (MBPH)