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Ppp3cc protein phosphatase 3, catalytic subunit, gamma isoform [ Mus musculus (house mouse) ]

Gene ID: 19057, updated on 11-Apr-2024

Summary

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Official Symbol
Ppp3ccprovided by MGI
Official Full Name
protein phosphatase 3, catalytic subunit, gamma isoformprovided by MGI
Primary source
MGI:MGI:107162
See related
Ensembl:ENSMUSG00000022092 AllianceGenome:MGI:107162
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Calnc; PP2BA gamma
Summary
Predicted to enable calmodulin binding activity and calmodulin-dependent protein phosphatase activity. Predicted to be involved in calcineurin-NFAT signaling cascade; positive regulation of synaptic vesicle endocytosis; and protein dephosphorylation. Is active in glutamatergic synapse and presynaptic cytosol. Is expressed in gastrocnemius muscle; ovary; and renal vasculature. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PPP3CC (protein phosphatase 3 catalytic subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 21.7), frontal lobe adult (RPKM 6.2) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Ppp3cc in Genome Data Viewer
Location:
14 D2; 14 36.3 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (70455314..70526979, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (70217864..70289536, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene PDZ and LIM domain 2 Neighboring gene STARR-positive B cell enhancer ABC_E7331 Neighboring gene sorbin and SH3 domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E10833 Neighboring gene predicted gene, 26908 Neighboring gene predicted gene, 33790 Neighboring gene STARR-seq mESC enhancer starr_37079 Neighboring gene STARR-positive B cell enhancer ABC_E4118 Neighboring gene STARR-seq mESC enhancer starr_37080 Neighboring gene solute carrier family 39 (zinc transporter), member 14 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-seq mESC enhancer starr_37081

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning of a calmodulin-dependent phosphatase from murine testis: identification of a developmentally expressed nonneural isoenzyme. Muramatsu T, et al. Proc Natl Acad Sci U S A, 1992 Jan 15. PMID 1309945, Free PMC Article
  2. Calcineurin Aγ is a Functional Phosphatase That Modulates Synaptic Vesicle Endocytosis. Cottrell JR, et al. J Biol Chem, 2016 Jan 22. PMID 26627835, Free PMC Article
  3. Cloning and characterization of molecular isoforms of the catalytic subunit of calcineurin using nonisotopic methods. Kincaid RL, et al. J Biol Chem, 1990 Jul 5. PMID 2162844
  4. Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit. Giri PR, et al. Biochem Biophys Res Commun, 1991 Nov 27. PMID 1659808
  5. Structure and expression of two isoforms of the murine calmodulin-dependent protein phosphatase regulatory subunit (calcineurin B). Ueki K, et al. Biochem Biophys Res Commun, 1992 Aug 31. PMID 1325794

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium-dependent protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium-dependent protein serine/threonine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables calcium-dependent protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcineurin-NFAT signaling cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in calcineurin-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of calcium ion import across plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within penetration of zona pellucida IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of calcineurin-NFAT signaling cascade NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of calcium ion import across plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of calcineurin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of calcineurin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of calcineurin complex IGI
Inferred from Genetic Interaction
more info
 PubMed 
part_of calcineurin complex NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in presynapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein serine/threonine phosphatase complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm midpiece IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm mitochondrial sheath IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
Names
CAM-PRP catalytic subunit
calcineurin, testis-specific catalytic subunit
NP_001291920.1
NP_001291921.1
NP_001347158.1
NP_001411449.1
NP_032941.1
XP_017171413.1
XP_030103550.1
XP_030103551.1
XP_036014406.1
XP_036014407.1
XP_036014408.1
XP_036014409.1
XP_036014410.1
XP_036014411.1
XP_036014412.1
XP_036014413.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304991.2 → NP_001291920.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC139294, AC151836
    Consensus CDS
    CCDS88703.1
    UniProtKB/TrEMBL
    A0A2I3BPC5, Q80XK0
    Related
    ENSMUSP00000153725.2, ENSMUST00000228911.2
    Conserved Domains (2) summary
    smart00156
    Location:54 → 325
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    cd07416
    Location:37 → 341
    MPP_PP2B; PP2B, metallophosphatase domain

  2. NM_001304992.2 → NP_001291921.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons and uses a downstream start codon compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AC139294, AC151836
    UniProtKB/TrEMBL
    Q80XK0
    Conserved Domains (1) summary
    cl13995
    Location:1 → 173
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain

  3. NM_001360229.2 → NP_001347158.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC139294, AC151836
    UniProtKB/TrEMBL
    Q9D5R5
    Related
    ENSMUST00000228265.2
    Conserved Domains (1) summary
    cd07416
    Location:37 → 341
    MPP_PP2B; PP2B, metallophosphatase domain

  4. NM_001424520.1 → NP_001411449.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC139294, AC151836

  5. NM_008915.4 → NP_032941.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 2

    See identical proteins and their annotated locations for NP_032941.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC139294, AC151836
    Consensus CDS
    CCDS36968.1
    UniProtKB/Swiss-Prot
    P48455, Q3V074
    UniProtKB/TrEMBL
    Q80XK0
    Related
    ENSMUSP00000077532.7, ENSMUST00000078434.8
    Conserved Domains (2) summary
    smart00156
    Location:54 → 325
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    cd07416
    Location:37 → 341
    MPP_PP2B; PP2B, metallophosphatase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    70455314..70526979 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158519.1 → XP_036014412.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X7

    Conserved Domains (1) summary
    cl13995
    Location:14 → 146
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain

  2. XM_036158518.1 → XP_036014411.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X7

    Conserved Domains (1) summary
    cl13995
    Location:14 → 146
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain

  3. XM_030247691.2 → XP_030103551.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X8

    Conserved Domains (1) summary
    cl13995
    Location:14 → 146
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain

  4. XM_036158516.1 → XP_036014409.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X5

    Conserved Domains (1) summary
    cl13995
    Location:1 → 173
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain

  5. XM_036158517.1 → XP_036014410.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X5

    Conserved Domains (1) summary
    cl13995
    Location:1 → 173
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain

  6. XM_017315924.3 → XP_017171413.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X8

    Conserved Domains (1) summary
    cl13995
    Location:14 → 146
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain

  7. XM_030247690.2 → XP_030103550.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X6

    Conserved Domains (1) summary
    cl13995
    Location:1 → 173
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain

  8. XM_036158515.1 → XP_036014408.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X4

    UniProtKB/TrEMBL
    Q80XK0
    Conserved Domains (1) summary
    cd07416
    Location:37 → 341
    MPP_PP2B; PP2B, metallophosphatase domain

  9. XM_036158513.1 → XP_036014406.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1

    UniProtKB/TrEMBL
    Q80XK0
    Conserved Domains (1) summary
    cd07416
    Location:37 → 341
    MPP_PP2B; PP2B, metallophosphatase domain

  10. XM_036158520.1 → XP_036014413.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X9

    Conserved Domains (1) summary
    cl13995
    Location:14 → 146
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain

  11. XM_036158514.1 → XP_036014407.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X3

    UniProtKB/TrEMBL
    Q9D5R5
    Conserved Domains (1) summary
    cd07416
    Location:37 → 341
    MPP_PP2B; PP2B, metallophosphatase domain

RNA

  1. XR_003950828.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48455.1 GenPept UniProtKB/Swiss-Prot:P48455

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