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Ppp2r3d protein phosphatase 2 (formerly 2A), regulatory subunit B'', delta [ Mus musculus (house mouse) ]

Gene ID: 19054, updated on 3-Apr-2024

Summary

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Official Symbol
Ppp2r3dprovided by MGI
Official Full Name
protein phosphatase 2 (formerly 2A), regulatory subunit B'', deltaprovided by MGI
Primary source
MGI:MGI:1335093
See related
AllianceGenome:MGI:1335093
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PR59; Ppp2r3; Ppp2r3a; PP2A PR59; PP2A B''-PR59
Summary
Enables calcium-dependent protein serine/threonine phosphatase activity; chromatin binding activity; and protein phosphatase regulator activity. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle; negative regulation of cell population proliferation; and protein dephosphorylation. Part of protein phosphatase type 2A complex. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human PPP2R3B (protein phosphatase 2 regulatory subunit B''beta). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See Ppp2r3d in Genome Data Viewer
Location:
9; 9 F4
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (124195310..124204755)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (124474346..124476862, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene NLR family, pyrin domain containing 4G Neighboring gene predicted gene, 20783 Neighboring gene RIKEN cDNA 4930526I15 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional interaction between a novel protein phosphatase 2A regulatory subunit, PR59, and the retinoblastoma-related p107 protein. Voorhoeve PM, et al. Oncogene, 1999 Jan 14. PMID 9927208
  2. Diversity in genomic organisation, developmental regulation and distribution of the murine PR72/B" subunits of protein phosphatase 2A. Zwaenepoel K, et al. BMC Genomics, 2008 Aug 20. PMID 18715506, Free PMC Article
  3. Glutamate Counteracts Dopamine/PKA Signaling via Dephosphorylation of DARPP-32 Ser-97 and Alteration of Its Cytonuclear Distribution. Nishi A, et al. J Biol Chem, 2017 Jan 27. PMID 27998980, Free PMC Article
  4. PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells. Yan Z, et al. Mol Cell Biol, 2000 Feb. PMID 10629059, Free PMC Article
  5. Identification of potential nuclear reprogramming and differentiation factors by a novel selection method for cloning chromatin-binding proteins. Wang L, et al. Biochem Biophys Res Commun, 2004 Dec 3. PMID 15522233

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 2A complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta
Names
protein phosphatase 2 (formerly 2A), regulatory subunit B'', alpha
protein phosphatase 2, regulatory subunit (59 kDa)
protein phosphatase 2, regulatory subunit B, alpha
protein phosphatase 2A, 59 kDa regulatory subunit B
serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
NP_001156887.1
NP_001392087.1
NP_035284.2
XP_036010587.1
XP_036010589.1
XP_036010590.1
XP_036010591.1
XP_036010592.1
XP_036010593.1
XP_036010594.1
XP_036010595.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163415.2 → NP_001156887.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform 1

    See identical proteins and their annotated locations for NP_001156887.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    LXEJ02012085
    UniProtKB/TrEMBL
    A0A7N9VRA1, Q8K1A4
    Conserved Domains (1) summary
    pfam13499
    Location:343 → 394
    EF-hand_7; EF-hand domain pair

  2. NM_001405158.1 → NP_001392087.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform 2

    Status: VALIDATED

    Source sequence(s)
    LXEJ02012085

  3. NM_011154.2 → NP_035284.2  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform 2

    See identical proteins and their annotated locations for NP_035284.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The resulting isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK054122, AK143212, BC096544, CB723063, CF735315
    UniProtKB/Swiss-Prot
    Q9Z176
    Conserved Domains (1) summary
    cl41751
    Location:71 → 426
    PPP2R3; serine/threonine protein phosphatase 2A regulatory subunit B"

RNA

  1. NR_028110.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' exon and contains multiple differences in internal exons, compared to variant 1. This variant is represented as non-coding because use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK054122, BC096544

  2. NR_102716.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' exon and contains multiple differences in internal exons, compared to variant 1. This variant is represented as non-coding because use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK054122, AK143212, BC096544

  3. NR_175917.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    LXEJ02012085

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    124195310..124204755
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154702.1 → XP_036010595.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform X8

    Conserved Domains (1) summary
    cl41751
    Location:2 → 198
    PPP2R3; serine/threonine protein phosphatase 2A regulatory subunit B"

  2. XM_036154694.1 → XP_036010587.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform X1

    UniProtKB/TrEMBL
    A0A7N9VRA1
    Conserved Domains (1) summary
    cl41751
    Location:105 → 460
    PPP2R3; serine/threonine protein phosphatase 2A regulatory subunit B"

  3. XM_036154700.1 → XP_036010593.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform X7

    Conserved Domains (1) summary
    cl41751
    Location:1 → 319
    PPP2R3; serine/threonine protein phosphatase 2A regulatory subunit B"

  4. XM_036154699.1 → XP_036010592.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform X6

    Conserved Domains (1) summary
    cl41751
    Location:1 → 319
    PPP2R3; serine/threonine protein phosphatase 2A regulatory subunit B"

  5. XM_036154696.1 → XP_036010589.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform X3

    UniProtKB/Swiss-Prot
    Q9Z176
    Conserved Domains (1) summary
    cl41751
    Location:71 → 426
    PPP2R3; serine/threonine protein phosphatase 2A regulatory subunit B"

  6. XM_036154701.1 → XP_036010594.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform X8

    Conserved Domains (1) summary
    cl41751
    Location:2 → 198
    PPP2R3; serine/threonine protein phosphatase 2A regulatory subunit B"

  7. XM_036154698.1 → XP_036010591.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform X5

    Conserved Domains (1) summary
    cd21504
    Location:157 → 395
    PPP2R3A_B-like; serine/threonine protein phosphatase 2A regulatory subunit B" alpha and beta subunits, and similar proteins

  8. XM_036154697.1 → XP_036010590.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform X4

    Conserved Domains (1) summary
    cd21504
    Location:157 → 395
    PPP2R3A_B-like; serine/threonine protein phosphatase 2A regulatory subunit B" alpha and beta subunits, and similar proteins

RNA

  1. XR_004935343.1 RNA Sequence

  2. XR_004935344.1 RNA Sequence

  3. XR_004935345.1 RNA Sequence

  4. XR_004935347.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001039134.1: Suppressed sequence

    Description
    NM_001039134.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z176.1 GenPept UniProtKB/Swiss-Prot:Q9Z176

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