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Ppox protoporphyrinogen oxidase [ Mus musculus (house mouse) ]

Gene ID: 19044, updated on 11-Apr-2024

Summary

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Official Symbol
Ppoxprovided by MGI
Official Full Name
protoporphyrinogen oxidaseprovided by MGI
Primary source
MGI:MGI:104968
See related
Ensembl:ENSMUSG00000062729 AllianceGenome:MGI:104968
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ppo
Summary
Enables oxygen-dependent protoporphyrinogen oxidase activity. Acts upstream of or within heme biosynthetic process. Is intrinsic component of mitochondrial inner membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study variegate porphyria. Human ortholog(s) of this gene implicated in variegate porphyria. Orthologous to human PPOX (protoporphyrinogen oxidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14.5 (RPKM 89.8), liver E14 (RPKM 78.0) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 H3; 1 79.3 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171104564..171108955, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171276991..171281193, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase core subunit S2 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 4 Neighboring gene UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3 Neighboring gene STARR-positive B cell enhancer mm9_chr1:173211225-173211526 Neighboring gene STARR-positive B cell enhancer mm9_chr1:173211857-173212158 Neighboring gene ubiquitin specific peptidase 21 Neighboring gene STARR-seq mESC enhancer starr_03026 Neighboring gene ubiquitin-fold modifier conjugating enzyme 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of the mouse protoporphyrinogen oxidase gene. Dailey TA, et al. Cell Mol Biol (Noisy-le-grand), 2002 Feb. PMID 11929049
  2. Mitochondrial targeting of normal and mutant protoporphyrinogen oxidase. von und zu Fraunberg M, et al. J Biol Chem, 2003 Apr 11. PMID 12556518
  3. A mouse model for South African (R59W) variegate porphyria: construction and initial characterization. Medlock AE, et al. Cell Mol Biol (Noisy-le-grand), 2002 Feb. PMID 11929050
  4. Cloning, sequence, and expression of mouse protoporphyrinogen oxidase. Dailey TA, et al. Arch Biochem Biophys, 1995 Dec 20. PMID 8554330
  5. Induction of terminal enzymes for heme biosynthesis during differentiation of mouse erythroleukemia cells. Taketani S, et al. Eur J Biochem, 1995 Jun 1. PMID 7607249

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. isolation, characterization and localization of gene.
    Title: Characterization of the mouse protoporphyrinogen oxidase gene.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxygen-dependent protoporphyrinogen oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxygen-dependent protoporphyrinogen oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxygen-dependent protoporphyrinogen oxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in heme A biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heme B biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heme O biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heme biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within heme biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heme biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in porphyrin-containing compound biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protoporphyrinogen IX metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
protoporphyrinogen oxidase
Names
protoporhyrinogen oxidase
NP_032937.1
XP_006496770.1
XP_006496772.1
XP_011237074.1
XP_011237075.1
XP_030108150.1
XP_030108151.1
XP_030108152.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008911.2 → NP_032937.1  protoporphyrinogen oxidase

    See identical proteins and their annotated locations for NP_032937.1

    Status: VALIDATED

    Source sequence(s)
    AC084821, AK142632, U25114
    Consensus CDS
    CCDS15487.1
    UniProtKB/Swiss-Prot
    P51175, P97344, Q99M34
    UniProtKB/TrEMBL
    Q3UQA3
    Related
    ENSMUSP00000072863.5, ENSMUST00000073120.11
    Conserved Domains (1) summary
    TIGR00562
    Location:3 → 471
    proto_IX_ox; protoporphyrinogen oxidase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    171104564..171108955 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496707.4 → XP_006496770.1  protoporphyrinogen oxidase isoform X1

    See identical proteins and their annotated locations for XP_006496770.1

    UniProtKB/Swiss-Prot
    P51175, P97344, Q99M34
    UniProtKB/TrEMBL
    Q3UQA3
    Conserved Domains (1) summary
    TIGR00562
    Location:3 → 471
    proto_IX_ox; protoporphyrinogen oxidase

  2. XM_030252290.1 → XP_030108150.1  protoporphyrinogen oxidase isoform X3

    UniProtKB/TrEMBL
    Q3UQA3
    Conserved Domains (1) summary
    TIGR00562
    Location:3 → 388
    proto_IX_ox; protoporphyrinogen oxidase

  3. XM_011238773.3 → XP_011237075.1  protoporphyrinogen oxidase isoform X2

    See identical proteins and their annotated locations for XP_011237075.1

    UniProtKB/TrEMBL
    Q3UQA3
    Conserved Domains (1) summary
    TIGR00562
    Location:18 → 427
    proto_IX_ox; protoporphyrinogen oxidase

  4. XM_030252292.1 → XP_030108152.1  protoporphyrinogen oxidase isoform X4

    Conserved Domains (1) summary
    TIGR00562
    Location:4 → 309
    proto_IX_ox; protoporphyrinogen oxidase

  5. XM_030252291.1 → XP_030108151.1  protoporphyrinogen oxidase isoform X4

    Conserved Domains (1) summary
    TIGR00562
    Location:4 → 309
    proto_IX_ox; protoporphyrinogen oxidase

  6. XM_011238772.3 → XP_011237074.1  protoporphyrinogen oxidase isoform X2

    See identical proteins and their annotated locations for XP_011237074.1

    UniProtKB/TrEMBL
    Q3UQA3
    Conserved Domains (1) summary
    TIGR00562
    Location:18 → 427
    proto_IX_ox; protoporphyrinogen oxidase

  7. XM_006496709.5 → XP_006496772.1  protoporphyrinogen oxidase isoform X3

    UniProtKB/TrEMBL
    Q3UQA3
    Conserved Domains (1) summary
    TIGR00562
    Location:3 → 388
    proto_IX_ox; protoporphyrinogen oxidase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51175.1 GenPept UniProtKB/Swiss-Prot:P51175

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