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Ppfibp2 PTPRF interacting protein, binding protein 2 (liprin beta 2) [ Mus musculus (house mouse) ]

Gene ID: 19024, updated on 3-Apr-2024

Summary

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Official Symbol
Ppfibp2provided by MGI
Official Full Name
PTPRF interacting protein, binding protein 2 (liprin beta 2)provided by MGI
Primary source
MGI:MGI:894649
See related
Ensembl:ENSMUSG00000036528 AllianceGenome:MGI:894649
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cclp1
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in neuromuscular junction development. Predicted to be active in presynaptic active zone. Is expressed in several structures, including alimentary system; bone; brain ventricle and choroid plexus; genitourinary system; and hemolymphoid system gland. Orthologous to human PPFIBP2 (PPFIA binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 12.0), placenta adult (RPKM 5.7) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 E3; 7 57.21 cM
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (107192608..107347790)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (107595047..107748583)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene synaptotagmin IX Neighboring gene STARR-seq mESC enhancer starr_19764 Neighboring gene STARR-positive B cell enhancer ABC_E8198 Neighboring gene olfactomedin-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E1352 Neighboring gene STARR-seq mESC enhancer starr_19765 Neighboring gene STARR-seq mESC enhancer starr_19766 Neighboring gene STARR-positive B cell enhancer mm9_chr7:114807884-114808185 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:114846576-114846777 Neighboring gene STARR-seq mESC enhancer starr_19769 Neighboring gene STARR-seq mESC enhancer starr_19770 Neighboring gene cytochrome b5 reductase 2 Neighboring gene ovochymase 2 Neighboring gene olfactory receptor family 5 subfamily P member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning and expression analysis of mouse Cclp1, a new gene encoding a coiled-coil-like protein. Noben-Trauth K, et al. Biochim Biophys Acta, 1997 May 30. PMID 9199242
  2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC117695

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in neuromuscular junction development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic active zone IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
liprin-beta-2
Names
PTPRF-interacting protein-binding protein 2
coiled-coil-like protein 1
protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2
protein tyrosine phosphatase, receptor-type, F interacting protein, binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163557.2 → NP_001157029.1  liprin-beta-2 isoform 2

    See identical proteins and their annotated locations for NP_001157029.1

    Status: VALIDATED

    Source sequence(s)
    AL513346
    Consensus CDS
    CCDS52356.1
    UniProtKB/Swiss-Prot
    O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
    Related
    ENSMUSP00000095738.4, ENSMUST00000098134.5
    Conserved Domains (5) summary
    cd09563
    Location:550 → 613
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:624 → 686
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:709 → 780
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    smart00454
    Location:550 → 614
    SAM; Sterile alpha motif
    pfam01519
    Location:110 → 161
    DUF16; Protein of unknown function DUF16

  2. NM_001357436.2 → NP_001344365.1  liprin-beta-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL513346
    UniProtKB/Swiss-Prot
    O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
    Conserved Domains (4) summary
    cd09563
    Location:484 → 547
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:558 → 620
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:643 → 714
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    cl25732
    Location:28 → 231
    SMC_N; RecF/RecN/SMC N terminal domain

  3. NM_001357437.2 → NP_001344366.1  liprin-beta-2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL513346
    UniProtKB/Swiss-Prot
    O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
    Conserved Domains (4) summary
    cd09563
    Location:473 → 536
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:547 → 609
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:632 → 703
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    cl25732
    Location:28 → 231
    SMC_N; RecF/RecN/SMC N terminal domain

  4. NM_001357438.2 → NP_001344367.1  liprin-beta-2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL513346
    UniProtKB/Swiss-Prot
    O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
    Conserved Domains (4) summary
    cd09563
    Location:400 → 463
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:474 → 536
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:559 → 630
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    cl25732
    Location:16 → 152
    SMC_N; RecF/RecN/SMC N terminal domain

  5. NM_001417148.1 → NP_001404077.1  liprin-beta-2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL513346

  6. NM_001417149.1 → NP_001404078.1  liprin-beta-2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL513346

  7. NM_001417150.1 → NP_001404079.1  liprin-beta-2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL513346

  8. NM_001417151.1 → NP_001404080.1  liprin-beta-2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL513346

  9. NM_001417152.1 → NP_001404081.1  liprin-beta-2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL513346

  10. NM_008905.3 → NP_032931.2  liprin-beta-2 isoform 1

    See identical proteins and their annotated locations for NP_032931.2

    Status: VALIDATED

    Source sequence(s)
    AL513346
    Consensus CDS
    CCDS21691.1
    UniProtKB/Swiss-Prot
    O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
    UniProtKB/TrEMBL
    G3X957
    Related
    ENSMUSP00000042574.8, ENSMUST00000040056.15
    Conserved Domains (5) summary
    cd09563
    Location:561 → 624
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:635 → 697
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:720 → 791
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    TIGR02168
    Location:105 → 308
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd22296
    Location:419 → 464
    CBD_TRPV5_C; C-terminal CaM binding domain found in transient receptor potential cation channel subfamily V member 5 (TRPV5) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    107192608..107347790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152792.1 → XP_036008685.1  liprin-beta-2 isoform X3

    UniProtKB/Swiss-Prot
    O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
    UniProtKB/TrEMBL
    G3X957
    Conserved Domains (5) summary
    cd09563
    Location:561 → 624
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:635 → 697
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:720 → 791
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    TIGR02168
    Location:105 → 308
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd22296
    Location:419 → 464
    CBD_TRPV5_C; C-terminal CaM binding domain found in transient receptor potential cation channel subfamily V member 5 (TRPV5) and similar proteins

  2. XM_030242235.1 → XP_030098095.1  liprin-beta-2 isoform X10

    UniProtKB/Swiss-Prot
    O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
    Conserved Domains (4) summary
    cd09563
    Location:597 → 660
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:671 → 733
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:756 → 827
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    TIGR02168
    Location:141 → 344
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  3. XM_006507443.3 → XP_006507506.1  liprin-beta-2 isoform X1

    UniProtKB/Swiss-Prot
    O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
    Conserved Domains (4) summary
    cd09563
    Location:597 → 660
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:671 → 733
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:756 → 827
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    TIGR02168
    Location:141 → 344
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  4. XM_006507444.3 → XP_006507507.1  liprin-beta-2 isoform X2

    UniProtKB/Swiss-Prot
    O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
    Conserved Domains (4) summary
    cd09563
    Location:586 → 649
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:660 → 722
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:745 → 816
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    TIGR02168
    Location:141 → 344
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  5. XM_006507453.1 → XP_006507516.1  liprin-beta-2 isoform X9

    See identical proteins and their annotated locations for XP_006507516.1

    UniProtKB/Swiss-Prot
    O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
    Conserved Domains (5) summary
    cd09563
    Location:403 → 466
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:477 → 539
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:562 → 633
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    TIGR02168
    Location:8 → 144
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd22296
    Location:261 → 306
    CBD_TRPV5_C; C-terminal CaM binding domain found in transient receptor potential cation channel subfamily V member 5 (TRPV5) and similar proteins

  6. XM_006507454.1 → XP_006507517.1  liprin-beta-2 isoform X9

    See identical proteins and their annotated locations for XP_006507517.1

    UniProtKB/Swiss-Prot
    O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
    Conserved Domains (5) summary
    cd09563
    Location:403 → 466
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:477 → 539
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:562 → 633
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    TIGR02168
    Location:8 → 144
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd22296
    Location:261 → 306
    CBD_TRPV5_C; C-terminal CaM binding domain found in transient receptor potential cation channel subfamily V member 5 (TRPV5) and similar proteins

  7. XM_036152795.1 → XP_036008688.1  liprin-beta-2 isoform X9

    UniProtKB/Swiss-Prot
    O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
    Conserved Domains (5) summary
    cd09563
    Location:403 → 466
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:477 → 539
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:562 → 633
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    TIGR02168
    Location:8 → 144
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd22296
    Location:261 → 306
    CBD_TRPV5_C; C-terminal CaM binding domain found in transient receptor potential cation channel subfamily V member 5 (TRPV5) and similar proteins

  8. XM_006507446.4 → XP_006507509.1  liprin-beta-2 isoform X5

    See identical proteins and their annotated locations for XP_006507509.1

    UniProtKB/Swiss-Prot
    O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
    Conserved Domains (4) summary
    cd09563
    Location:481 → 544
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:555 → 617
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:640 → 711
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    TIGR02168
    Location:25 → 228
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  9. XM_006507452.5 → XP_006507515.1  liprin-beta-2 isoform X9

    See identical proteins and their annotated locations for XP_006507515.1

    UniProtKB/Swiss-Prot
    O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
    Conserved Domains (5) summary
    cd09563
    Location:403 → 466
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:477 → 539
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:562 → 633
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    TIGR02168
    Location:8 → 144
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd22296
    Location:261 → 306
    CBD_TRPV5_C; C-terminal CaM binding domain found in transient receptor potential cation channel subfamily V member 5 (TRPV5) and similar proteins

  10. XM_006507455.5 → XP_006507518.1  liprin-beta-2 isoform X9

    See identical proteins and their annotated locations for XP_006507518.1

    UniProtKB/Swiss-Prot
    O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
    Conserved Domains (5) summary
    cd09563
    Location:403 → 466
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:477 → 539
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:562 → 633
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    TIGR02168
    Location:8 → 144
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd22296
    Location:261 → 306
    CBD_TRPV5_C; C-terminal CaM binding domain found in transient receptor potential cation channel subfamily V member 5 (TRPV5) and similar proteins

  11. XM_006507448.4 → XP_006507511.1  liprin-beta-2 isoform X7

    See identical proteins and their annotated locations for XP_006507511.1

    UniProtKB/Swiss-Prot
    O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
    Conserved Domains (4) summary
    cd09563
    Location:411 → 474
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:485 → 547
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:570 → 641
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    TIGR02168
    Location:16 → 152
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  12. XM_006507449.4 → XP_006507512.1  liprin-beta-2 isoform X7

    See identical proteins and their annotated locations for XP_006507512.1

    UniProtKB/Swiss-Prot
    O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
    Conserved Domains (4) summary
    cd09563
    Location:411 → 474
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:485 → 547
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:570 → 641
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    TIGR02168
    Location:16 → 152
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  13. XM_006507450.4 → XP_006507513.1  liprin-beta-2 isoform X7

    See identical proteins and their annotated locations for XP_006507513.1

    UniProtKB/Swiss-Prot
    O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
    Conserved Domains (4) summary
    cd09563
    Location:411 → 474
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:485 → 547
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:570 → 641
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    TIGR02168
    Location:16 → 152
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  14. XM_006507451.1 → XP_006507514.1  liprin-beta-2 isoform X8

    Conserved Domains (4) summary
    cd09563
    Location:404 → 467
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:478 → 540
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:563 → 634
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    PRK03918
    Location:46 → 197
    PRK03918; DNA double-strand break repair ATPase Rad50
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35711.3 GenPept UniProtKB/Swiss-Prot:O35711

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