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Endou endonuclease, polyU-specific [ Mus musculus (house mouse) ]

Gene ID: 19011, updated on 9-May-2024

Summary

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Official Symbol
Endouprovided by MGI
Official Full Name
endonuclease, polyU-specificprovided by MGI
Primary source
MGI:MGI:97746
See related
Ensembl:ENSMUSG00000022468 AllianceGenome:MGI:97746
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pp11r; Tcl-30
Summary
Predicted to enable RNA binding activity and endoribonuclease activity. Predicted to be involved in proteolysis. Predicted to be located in cytoplasm. Is expressed in ileum; labyrinthine zone; and metanephros. Orthologous to human ENDOU (endonuclease, poly(U) specific). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 54.3) and lung adult (RPKM 2.5) See more
Orthologs
human all
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Genomic context

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Location:
15 F1; 15 53.7 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (97608896..97629286, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (97711015..97731405, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41394 Neighboring gene STARR-positive B cell enhancer ABC_E10876 Neighboring gene RNA polymerase II associated protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E7415 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:97551732-97551973 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:97561501-97561858 Neighboring gene STARR-positive B cell enhancer ABC_E5512 Neighboring gene STARR-positive B cell enhancer ABC_E2450 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:97580414-97580523 Neighboring gene Rap guanine nucleotide exchange factor (GEF) 3 Neighboring gene predicted gene, 33531 Neighboring gene STARR-seq mESC enhancer starr_39638 Neighboring gene STARR-positive B cell enhancer ABC_E5513 Neighboring gene Rap guanine nucleotide exchange factor (GEF) 3, opposite strand 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tcl-30, a new T cell-specific gene expressed in immature glucocorticoid-sensitive thymocytes. Baughman G, et al. J Immunol, 1992 Sep 1. PMID 1506680
  2. EndoU is a novel regulator of AICD during peripheral B cell selection. Poe JC, et al. J Exp Med, 2014 Jan 13. PMID 24344237, Free PMC Article
  3. Genetic mapping of Pp11r, a thymocyte gene expressed during apoptosis, to mouse chromosome 15. Kingsmore SF, et al. Mamm Genome, 1993. PMID 8104059
  4. Genes newly identified as regulated by glucocorticoids in murine thymocytes. Baughman G, et al. Mol Endocrinol, 1991 May. PMID 2072923
  5. The eutheria-specific miR-290 cluster modulates placental growth and maternal-fetal transport. Paikari A, et al. Development, 2017 Oct 15. PMID 28935707, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables polysaccharide binding IEA
Inferred from Electronic Annotation
more info
  
enables scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of lipid catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in post-transcriptional gene silencing ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uridylate-specific endoribonuclease
Names
PP11-related protein
T-cell-specific protein 30
placental protein 11 related
placental protein 11-related protein
poly(U)-specific endoribonuclease
protein endoU

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168693.1 → NP_001162164.1  uridylate-specific endoribonuclease isoform 2 precursor

    See identical proteins and their annotated locations for NP_001162164.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains different segments for its 5' UTR and coding region, compared to variant 1. The predicted protein (isoform 2) results from translation initiation at an upstream AUG and has a shorter N-terminus, when it is compared to isoform 1.
    Source sequence(s)
    AA119943, AC104225, AK132616
    Consensus CDS
    CCDS49712.1
    UniProtKB/Swiss-Prot
    Q01084, Q3V188
    Related
    ENSMUSP00000097820.3, ENSMUST00000100249.10
    Conserved Domains (2) summary
    pfam01033
    Location:22 → 60
    Somatomedin_B; Somatomedin B domain
    pfam09412
    Location:140 → 406
    XendoU; Endoribonuclease XendoU

  2. NM_008902.3 → NP_032928.1  uridylate-specific endoribonuclease isoform 1

    See identical proteins and their annotated locations for NP_032928.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AC104225
    Consensus CDS
    CCDS27783.1
    UniProtKB/Swiss-Prot
    Q3V188
    Related
    ENSMUSP00000023105.4, ENSMUST00000023105.5
    Conserved Domains (2) summary
    pfam01033
    Location:130 → 167
    Somatomedin_B; Somatomedin B domain
    pfam09412
    Location:182 → 448
    XendoU; Endoribonuclease XendoU

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    97608896..97629286 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520618.2 → XP_006520681.1  uridylate-specific endoribonuclease isoform X2

    Conserved Domains (2) summary
    pfam01033
    Location:6 → 44
    Somatomedin_B; Somatomedin B domain
    pfam09412
    Location:124 → 390
    XendoU; Endoribonuclease XendoU

  2. XM_006520617.4 → XP_006520680.2  uridylate-specific endoribonuclease isoform X1

    Conserved Domains (2) summary
    pfam01033
    Location:46 → 84
    Somatomedin_B; Somatomedin B domain
    pfam09412
    Location:164 → 430
    XendoU; Endoribonuclease XendoU

  3. XM_017316511.1 → XP_017172000.1  uridylate-specific endoribonuclease isoform X3

    Conserved Domains (2) summary
    pfam01033
    Location:34 → 71
    Somatomedin_B; Somatomedin B domain
    pfam09412
    Location:86 → 352
    XendoU; Endoribonuclease XendoU
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3V188.1 GenPept UniProtKB/Swiss-Prot:Q3V188

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