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Pou6f1 POU domain, class 6, transcription factor 1 [ Mus musculus (house mouse) ]

Gene ID: 19009, updated on 3-Apr-2024

Summary

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Official Symbol
Pou6f1provided by MGI
Official Full Name
POU domain, class 6, transcription factor 1provided by MGI
Primary source
MGI:MGI:102935
See related
Ensembl:ENSMUSG00000009739 AllianceGenome:MGI:102935
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Emb; cns-1; 2310038G18Rik
Summary
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including genitourinary system; limb; nervous system; sensory organ; and skeletal musculature. Orthologous to human POU6F1 (POU class 6 homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 22.0), cortex adult (RPKM 16.2) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 F1; 15 56.35 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (100473199..100497949, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (100575318..100600061, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene cysteine-serine-rich nuclear protein 2 Neighboring gene STARR-seq mESC enhancer starr_39756 Neighboring gene transcription factor CP2 Neighboring gene STARR-positive B cell enhancer ABC_E7419 Neighboring gene STARR-seq mESC enhancer starr_39757 Neighboring gene STARR-positive B cell enhancer ABC_E4150 Neighboring gene RIKEN cDNA C330013E15 gene Neighboring gene STARR-positive B cell enhancer ABC_E610 Neighboring gene DAZ associated protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. POU6f1 Mediates Neuropeptide-Dependent Plasticity in the Adult Brain. McClard CK, et al. J Neurosci, 2018 Feb 7. PMID 29305536, Free PMC Article
  2. Identifying Tmem59 related gene regulatory network of mouse neural stem cell from a compendium of expression profiles. Zhang L, et al. BMC Syst Biol, 2011 Sep 29. PMID 21955788, Free PMC Article
  3. Transcription factor POU6F1 is important for proliferation of clear cell adenocarcinoma of the ovary and is a potential new molecular target. Suzuki N, et al. Int J Gynecol Cancer, 2010 Feb. PMID 20134265
  4. The in vivo form of the murine class VI POU protein Emb is larger than that encoded by previously described transcripts. Relaix F, et al. Gene, 2004 May 26. PMID 15177678
  5. NMDA receptor activation in differentiating cerebellar cell cultures regulates the expression of a new POU gene, Cns-1. Bulleit RF, et al. J Neurosci, 1994 Mar. PMID 7907365, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNA exosome ribonuclease DIS3 degrades Pou6f1 to promote mouse pre-implantation cell differentiation.
    Title: RNA exosome ribonuclease DIS3 degrades Pou6f1 to promote mouse pre-implantation cell differentiation.
  2. POU6f1 is necessary for proper dendrite specification and patterning, as well as synapse development and function in adult-born neurons
    Title: POU6f1 Mediates Neuropeptide-Dependent Plasticity in the Adult Brain.
  3. pou6f1 significantly regulates tmem59 and might play an important role in the differentiation of neural stem cells in mouse brain.
    Title: Identifying Tmem59 related gene regulatory network of mouse neural stem cell from a compendium of expression profiles.
  4. POU6F1 siRNA suppressed the proliferation of clear cell adenocarcinoma transplanted into nude mice.
    Title: Transcription factor POU6F1 is important for proliferation of clear cell adenocarcinoma of the ovary and is a potential new molecular target.
  5. These results demonstrate the importance of the Emb-MEF2D-histone transacetylase p300 complex in the transcriptional regulation of the cardiac actin gene and suggest a potential role in chromatin remodeling associated with muscle gene activation.
    Title: A novel complex regulates cardiac actin gene expression through interaction of Emb, a class VI POU domain protein, MEF2D, and the histone transacetylase p300.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
POU domain, class 6, transcription factor 1
Names
octamer-binding transcription factor EMB
transcription regulatory protein MCP-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304965.2 → NP_001291894.1  POU domain, class 6, transcription factor 1 isoform 1

    See identical proteins and their annotated locations for NP_001291894.1

    Status: VALIDATED

    Source sequence(s)
    AC123724
    Consensus CDS
    CCDS79411.1
    UniProtKB/TrEMBL
    Q5U4D4, Q6X2S0
    Related
    ENSMUSP00000073504.7, ENSMUST00000073837.13
    Conserved Domains (2) summary
    pfam00046
    Location:512 → 565
    Homeobox; Homeobox domain
    cl22952
    Location:414 → 488
    Pou; Pou domain - N-terminal to homeobox domain

  2. NM_001404294.1 → NP_001391223.1  POU domain, class 6, transcription factor 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC123724

  3. NM_001404295.1 → NP_001391224.1  POU domain, class 6, transcription factor 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC123724
    UniProtKB/Swiss-Prot
    Q07916, Q91XK3

  4. NM_001404296.1 → NP_001391225.1  POU domain, class 6, transcription factor 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC123724
    UniProtKB/Swiss-Prot
    Q07916, Q91XK3

  5. NM_001404297.1 → NP_001391226.1  POU domain, class 6, transcription factor 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC123724
    UniProtKB/Swiss-Prot
    Q07916, Q91XK3
    Related
    ENSMUSP00000145707.2, ENSMUST00000176271.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    100473199..100497949 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248418.2 → XP_030104278.1  POU domain, class 6, transcription factor 1 isoform X5

    UniProtKB/TrEMBL
    Q6X2S0
    Conserved Domains (3) summary
    PHA03247
    Location:98 → 390
    PHA03247; large tegument protein UL36; Provisional
    pfam00046
    Location:511 → 565
    Homeobox; Homeobox domain
    cl22952
    Location:413 → 487
    Pou; Pou domain - N-terminal to homeobox domain

  2. XM_006520614.5 → XP_006520677.1  POU domain, class 6, transcription factor 1 isoform X8

    Conserved Domains (3) summary
    PRK12323
    Location:46 → 263
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam00046
    Location:337 → 391
    Homeobox; Homeobox domain
    cl22952
    Location:287 → 313
    Pou; Pou domain - N-terminal to homeobox domain

  3. XM_017316508.3 → XP_017171997.1  POU domain, class 6, transcription factor 1 isoform X6

    UniProtKB/TrEMBL
    Q6X2S0
    Conserved Domains (3) summary
    PHA03247
    Location:58 → 378
    PHA03247; large tegument protein UL36; Provisional
    pfam00046
    Location:478 → 532
    Homeobox; Homeobox domain
    cl22952
    Location:380 → 454
    Pou; Pou domain - N-terminal to homeobox domain

  4. XM_017316509.2 → XP_017171998.1  POU domain, class 6, transcription factor 1 isoform X7

    Conserved Domains (1) summary
    PHA03247
    Location:48 → 452
    PHA03247; large tegument protein UL36; Provisional

  5. XM_030248417.2 → XP_030104277.1  POU domain, class 6, transcription factor 1 isoform X3

    UniProtKB/TrEMBL
    Q6X2S0
    Conserved Domains (3) summary
    PHA03247
    Location:31 → 406
    PHA03247; large tegument protein UL36; Provisional
    pfam00046
    Location:527 → 581
    Homeobox; Homeobox domain
    cl22952
    Location:429 → 503
    Pou; Pou domain - N-terminal to homeobox domain

  6. XM_006520609.4 → XP_006520672.1  POU domain, class 6, transcription factor 1 isoform X2

    UniProtKB/TrEMBL
    Q6X2S0
    Conserved Domains (3) summary
    PHA03247
    Location:50 → 424
    PHA03247; large tegument protein UL36; Provisional
    pfam00046
    Location:545 → 599
    Homeobox; Homeobox domain
    cl22952
    Location:447 → 521
    Pou; Pou domain - N-terminal to homeobox domain

  7. XM_030248416.1 → XP_030104276.1  POU domain, class 6, transcription factor 1 isoform X1

    UniProtKB/TrEMBL
    Q6X2S0
    Conserved Domains (3) summary
    PHA03247
    Location:48 → 425
    PHA03247; large tegument protein UL36; Provisional
    pfam00046
    Location:546 → 600
    Homeobox; Homeobox domain
    cl22952
    Location:448 → 522
    Pou; Pou domain - N-terminal to homeobox domain

  8. XM_006520608.4 → XP_006520671.1  POU domain, class 6, transcription factor 1 isoform X1

    UniProtKB/TrEMBL
    Q6X2S0
    Conserved Domains (3) summary
    PHA03247
    Location:48 → 425
    PHA03247; large tegument protein UL36; Provisional
    pfam00046
    Location:546 → 600
    Homeobox; Homeobox domain
    cl22952
    Location:448 → 522
    Pou; Pou domain - N-terminal to homeobox domain

  9. XM_030248419.1 → XP_030104279.1  POU domain, class 6, transcription factor 1 isoform X9

    Conserved Domains (3) summary
    PRK14951
    Location:41 → 158
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    pfam00046
    Location:267 → 321
    Homeobox; Homeobox domain
    cl22952
    Location:169 → 243
    Pou; Pou domain - N-terminal to homeobox domain

  10. XM_036159263.1 → XP_036015156.1  POU domain, class 6, transcription factor 1 isoform X10

    Conserved Domains (2) summary
    PHA03247
    Location:58 → 295
    PHA03247; large tegument protein UL36; Provisional
    PRK07994
    Location:170 → 272
    PRK07994; DNA polymerase III subunits gamma and tau; Validated

RNA

  1. XR_004938810.1 RNA Sequence

    Related
    ENSMUST00000176140.8

  2. XR_004938809.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_010127.3: Suppressed sequence

    Description
    NM_010127.3: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07916.1 GenPept UniProtKB/Swiss-Prot:Q07916

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