U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pou2f3 POU domain, class 2, transcription factor 3 [ Mus musculus (house mouse) ]

Gene ID: 18988, updated on 9-May-2024

Summary

Go to the top of the page Help
Official Symbol
Pou2f3provided by MGI
Official Full Name
POU domain, class 2, transcription factor 3provided by MGI
Primary source
MGI:MGI:102565
See related
Ensembl:ENSMUSG00000032015 AllianceGenome:MGI:102565
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Skin; Oct11; Otf11; Epoc-1; Otf-11; Skn-1a; Skn-li; Oct-11a; Skin-1a
Summary
Enables identical protein binding activity and sequence-specific DNA binding activity. Acts upstream of or within keratinocyte differentiation; positive regulation of transcription by RNA polymerase II; and wound healing. Part of transcription regulator complex. Is expressed in several structures, including early conceptus; genitourinary system; gut; skin; and thymus. Orthologous to human POU2F3 (POU class 2 homeobox 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in limb E14.5 (RPKM 2.0), placenta adult (RPKM 1.8) and 11 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
9 A5.1; 9 24.21 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (43035222..43117052, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (43123927..43205755, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 12 Neighboring gene STARR-seq mESC enhancer starr_23915 Neighboring gene Sp140 nuclear body protein family member pseudogene Neighboring gene STARR-seq mESC enhancer starr_23916 Neighboring gene TLC domain containing 5 Neighboring gene STARR-seq mESC enhancer starr_23926 Neighboring gene ribosomal protein L26, pseudogene 6 Neighboring gene out at first homolog

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Function, Innervation, and Neurotransmitter Signaling in Mice Lacking Type-II Taste Cells. Larson ED, et al. eNeuro, 2020 Jan/Feb. PMID 31988217, Free PMC Article
  2. Chemical Exposure-Induced Changes in the Expression of Neurotrophins and Their Receptors in the Main Olfactory System of Mice Lacking TRPM5-Expressing Microvillous Cells. AlMatrouk A, et al. Int J Mol Sci, 2018 Sep 27. PMID 30261693, Free PMC Article
  3. A large increase of sour taste receptor cells in Skn-1-deficient mice does not alter the number of their sour taste signal-transmitting gustatory neurons. Maeda N, et al. Neurosci Lett, 2017 May 1. PMID 28359935
  4. Expression and nuclear translocation of glucocorticoid receptors in type 2 taste receptor cells. Parker MR, et al. Neurosci Lett, 2014 Jun 13. PMID 24814581, Free PMC Article
  5. Pou2f3/Skn-1a is necessary for the generation or differentiation of solitary chemosensory cells in the anterior nasal cavity. Ohmoto M, et al. Biosci Biotechnol Biochem, 2013. PMID 24096675, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study demonstrated that Skn-1a is only expressed when neuropeptide Y (NPY) is activated in microvillar cells (MVCs). Therefore the expression of NPY is necessary for the transcription factor-mediated differentiation of olfactory MVCs.
    Title: Role of neuropeptide Y (NPY) in the differentiation of Trpm-5-positive olfactory microvillar cells.
  2. propose that Skn-1a/Pou2f3 is the master regulator for the generation of the Trpm5-expressing microvillous cells in multiple tissues
    Title: Skn-1a/Pou2f3 functions as a master regulator to generate Trpm5-expressing chemosensory cells in mice.
  3. Study reveals a large increase of sour taste receptor cells in Skn-1-deficient mice does not alter the number of their sour taste signal-transmitting gustatory neurons
    Title: A large increase of sour taste receptor cells in Skn-1-deficient mice does not alter the number of their sour taste signal-transmitting gustatory neurons.
  4. Pou2f3/Skn-1a , which is necessary for generation of sweet, umami, and bitter taste cells, is also necessary for the generation or differentiation of solitary chemosensory cells
    Title: Pou2f3/Skn-1a is necessary for the generation or differentiation of solitary chemosensory cells in the anterior nasal cavity.
  5. Oct-6 and Oct-11 contribute to the regulation of loricrin gene transcription via interaction with AP-1 factors and Sp1/Sp3.
    Title: The POU domain transcription factors Oct-6 and Oct-11 negatively regulate loricrin gene expression in keratinocytes: association with AP-1 and Sp1/Sp3.
  6. Skn-1a is critical for generating and balancing the diverse composition of taste cells.
    Title: Skn-1a (Pou2f3) specifies taste receptor cell lineage.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within epidermis development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in epidermis development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within keratinocyte differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation by host of viral transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within wound healing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
POU domain, class 2, transcription factor 3
Names
oct-11
octamer-binding protein 11
octamer-binding transcription factor 11

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011139.2 → NP_035269.2  POU domain, class 2, transcription factor 3

    See identical proteins and their annotated locations for NP_035269.2

    Status: VALIDATED

    Source sequence(s)
    AC110169, AC173346, AK153697
    Consensus CDS
    CCDS40596.1
    UniProtKB/Swiss-Prot
    H3BJT4, P31362
    Related
    ENSMUSP00000135115.2, ENSMUST00000176636.5
    Conserved Domains (2) summary
    smart00352
    Location:176 → 250
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:277 → 330
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    43035222..43117052 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242420.3 → XP_011240722.1  POU domain, class 2, transcription factor 3 isoform X1

    See identical proteins and their annotated locations for XP_011240722.1

    UniProtKB/TrEMBL
    G3X913, Q3U5D1
    Related
    ENSMUSP00000034513.6, ENSMUST00000034513.13
    Conserved Domains (3) summary
    smart00352
    Location:164 → 238
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:265 → 319
    Homeobox; Homeobox domain
    pfam09770
    Location:39 → 151
    PAT1; Topoisomerase II-associated protein PAT1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P31362.3 GenPept UniProtKB/Swiss-Prot:P31362

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous