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Pou2f1 POU domain, class 2, transcription factor 1 [ Mus musculus (house mouse) ]

Gene ID: 18986, updated on 5-Mar-2024

Summary

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Official Symbol
Pou2f1provided by MGI
Official Full Name
POU domain, class 2, transcription factor 1provided by MGI
Primary source
MGI:MGI:101898
See related
Ensembl:ENSMUSG00000026565 AllianceGenome:MGI:101898
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Oct1; Otf1; NF-A1; Oct-1; Otf-1; 2810482H01Rik
Summary
Enables chromatin binding activity and sequence-specific DNA binding activity. Acts upstream of or within lens induction in camera-type eye; olfactory placode formation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; genitourinary system; lung; sensory organ; and tooth. Orthologous to human POU2F1 (POU class 2 homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 4.4), whole brain E14.5 (RPKM 3.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 H2.3; 1 73.21 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (165692719..165830318, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (165865150..166002749, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CD247 antigen Neighboring gene predicted gene, 23402 Neighboring gene STARR-seq mESC enhancer starr_02912 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:167775596-167775783 Neighboring gene predicted gene, 32999 Neighboring gene STARR-seq mESC enhancer starr_02913 Neighboring gene STARR-positive B cell enhancer ABC_E3324 Neighboring gene STARR-positive B cell enhancer ABC_E9065 Neighboring gene STARR-positive B cell enhancer ABC_E2581 Neighboring gene STARR-positive B cell enhancer ABC_E4375 Neighboring gene STARR-positive B cell enhancer ABC_E4376 Neighboring gene STARR-positive B cell enhancer mm9_chr1:167878460-167878761 Neighboring gene heat shock protein 8 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2582 Neighboring gene STARR-seq mESC enhancer starr_02914 Neighboring gene STARR-positive B cell enhancer ABC_E798 Neighboring gene STARR-seq mESC enhancer starr_02915 Neighboring gene STARR-seq mESC enhancer starr_02916 Neighboring gene predicted gene, 53642 Neighboring gene transcription elongation factor B polypeptide 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Oct1 cooperates with the Smad family of transcription factors to promote mesodermal lineage specification. Perovanovic J, et al. Sci Signal, 2023 Apr 18. PMID 37071732, Free PMC Article
  2. Exercise training attenuates angiotensin II-induced cardiac fibrosis by reducing POU2F1 expression. Feng N, et al. J Sport Health Sci, 2023 Jul. PMID 36374849, Free PMC Article
  3. 5-Azacytidine Suppresses the Expression of Tissue-Specific Oct-1 Isoform in Namalwa Burkitt's Lymphoma Cell Culture. Kotnova AP, et al. Dokl Biochem Biophys, 2022 Apr. PMID 35538282, Free PMC Article
  4. Pathological matrix stiffness promotes cardiac fibroblast differentiation through the POU2F1 signaling pathway. Li M, et al. Sci China Life Sci, 2021 Feb. PMID 32617828
  5. T cell-selective deletion of Oct1 protects animals from autoimmune neuroinflammation while maintaining neurotropic pathogen response. Kim H, et al. J Neuroinflammation, 2019 Jul 3. PMID 31266507, Free PMC Article

See all (138) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exercise training attenuates angiotensin II-induced cardiac fibrosis by reducing POU2F1 expression.
    Title: Exercise training attenuates angiotensin II-induced cardiac fibrosis by reducing POU2F1 expression.
  2. Oct1 cooperates with the Smad family of transcription factors to promote mesodermal lineage specification.
    Title: Oct1 cooperates with the Smad family of transcription factors to promote mesodermal lineage specification.
  3. 5-Azacytidine Suppresses the Expression of Tissue-Specific Oct-1 Isoform in Namalwa Burkitt's Lymphoma Cell Culture.
    Title: 5-Azacytidine Suppresses the Expression of Tissue-Specific Oct-1 Isoform in Namalwa Burkitt's Lymphoma Cell Culture.
  4. LncRNA NEAT1 Promotes Inflammatory Response in Sepsis via the miR-31-5p/POU2F1 Axis.
    Title: LncRNA NEAT1 Promotes Inflammatory Response in Sepsis via the miR-31-5p/POU2F1 Axis.
  5. OBF1 and Oct factors control the germinal center transcriptional program.
    Title: OBF1 and Oct factors control the germinal center transcriptional program.
  6. Pathological matrix stiffness promotes cardiac fibroblast differentiation through the POU2F1 signaling pathway.
    Title: Pathological matrix stiffness promotes cardiac fibroblast differentiation through the POU2F1 signaling pathway.
  7. Pharmacokinetics of Organic Cation Transporter 1 (OCT1) Substrates in Oct1/2 Knockout Mice and Species Difference in Hepatic OCT1-Mediated Uptake.
    Title: Pharmacokinetics of Organic Cation Transporter 1 (OCT1) Substrates in Oct1/2 Knockout Mice and Species Difference in Hepatic OCT1-Mediated Uptake.
  8. Pou2f1 and Pou2f2 cooperate to control the timing of cone photoreceptor production in the developing mouse retina.
    Title: Pou2f1 and Pou2f2 cooperate to control the timing of cone photoreceptor production in the developing mouse retina.
  9. In MLL-AF9-driven mouse models, partial loss of Oct1 protects from myeloid leukemia. Complete Oct1 loss completely suppresses leukemia but results in lethality from bone marrow failure. Loss of Oct1 in normal hematopoietic transplants results in superficially normal long-term reconstitution; however, animals become acutely sensitive to 5-fluorouracil, indicating that Oct1 is dispensable for normal hematopoiesis.
    Title: Transcription factor Oct1 protects against hematopoietic stress and promotes acute myeloid leukemia.
  10. Oct1-deficient T cells mitigated reduced infiltrating T cells and cytokine production in an autoimmune neuroinflammation disease model.
    Title: T cell-selective deletion of Oct1 protects animals from autoimmune neuroinflammation while maintaining neurotropic pathogen response.
Submit: New GeneRIF Correction See all GeneRIFs (47)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lens induction in camera-type eye IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within olfactory placode formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
POU domain, class 2, transcription factor 1
Names
octamer-binding protein 1
octamer-binding transcription factor 1
ubiquitous transcription factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368808.1 → NP_001355737.1  POU domain, class 2, transcription factor 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC093371
    UniProtKB/Swiss-Prot
    P25425, Q61994, Q63891, Q6Y681, Q7TSD0, Q8BT04, Q8K570, Q99JH0, Q9WTZ4, Q9WTZ5, Q9WTZ6
    UniProtKB/TrEMBL
    A0A0A0MQE0
    Conserved Domains (2) summary
    smart00352
    Location:281 → 355
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:385 → 439
    Homeobox; Homeobox domain

  2. NM_011137.3 → NP_035267.2  POU domain, class 2, transcription factor 1 isoform A

    See identical proteins and their annotated locations for NP_035267.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (A).
    Source sequence(s)
    AC093371, AK028237
    Consensus CDS
    CCDS35760.1
    UniProtKB/TrEMBL
    A0A0A0MQE0, A0A0R4J1Z4
    Related
    ENSMUSP00000124738.2, ENSMUST00000160260.9
    Conserved Domains (2) summary
    smart00352
    Location:304 → 378
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:408 → 461
    Homeobox; Homeobox domain

  3. NM_198932.3 → NP_945150.2  POU domain, class 2, transcription factor 1 isoform Z

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. It encodes isoform Z, which is shorter than isoform A.
    Source sequence(s)
    AC093371
    Consensus CDS
    CCDS48430.1
    UniProtKB/TrEMBL
    E9Q6Z8, I1E4X2
    Related
    ENSMUSP00000125444.2, ENSMUST00000160908.8
    Conserved Domains (2) summary
    smart00352
    Location:304 → 378
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:408 → 461
    Homeobox; Homeobox domain

  4. NM_198933.3 → NP_945151.2  POU domain, class 2, transcription factor 1 isoform L

    See identical proteins and their annotated locations for NP_945151.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' terminal exon and lacks an in-frame exon in the coding region, compared to variant 1. It encodes isoform L, which is shorter and has a distinct N-terminus, compared to isoform A.
    Source sequence(s)
    AC093371
    Consensus CDS
    CCDS15444.1
    UniProtKB/TrEMBL
    A0A0A0MQE0
    Related
    ENSMUSP00000064000.6, ENSMUST00000069609.12
    Conserved Domains (2) summary
    smart00352
    Location:293 → 367
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:397 → 450
    Homeobox; Homeobox domain

  5. NM_198934.3 → NP_945152.2  POU domain, class 2, transcription factor 1 isoform B

    See identical proteins and their annotated locations for NP_945152.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate 5' terminal exon, compared to variant 1. It encodes isoform B, which is shorter and has a distinct N-terminus, compared to isoform A.
    Source sequence(s)
    AC093371
    Consensus CDS
    CCDS35761.1
    UniProtKB/TrEMBL
    A0A0A0MQE0, F8VQL7
    Related
    ENSMUSP00000107056.3, ENSMUST00000111427.9
    Conserved Domains (2) summary
    smart00352
    Location:293 → 367
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:397 → 450
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    165692719..165830318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252286.1 → XP_030108146.1  POU domain, class 2, transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    P25425, Q61994, Q63891, Q6Y681, Q7TSD0, Q8BT04, Q8K570, Q99JH0, Q9WTZ4, Q9WTZ5, Q9WTZ6
    UniProtKB/TrEMBL
    A0A0A0MQE0
    Conserved Domains (2) summary
    smart00352
    Location:281 → 355
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:385 → 439
    Homeobox; Homeobox domain

  2. XM_006496704.4 → XP_006496767.1  POU domain, class 2, transcription factor 1 isoform X1

    See identical proteins and their annotated locations for XP_006496767.1

    UniProtKB/Swiss-Prot
    P25425, Q61994, Q63891, Q6Y681, Q7TSD0, Q8BT04, Q8K570, Q99JH0, Q9WTZ4, Q9WTZ5, Q9WTZ6
    UniProtKB/TrEMBL
    A0A0A0MQE0
    Conserved Domains (2) summary
    smart00352
    Location:281 → 355
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:385 → 439
    Homeobox; Homeobox domain

  3. XM_030252287.2 → XP_030108147.1  POU domain, class 2, transcription factor 1 isoform X2

    UniProtKB/TrEMBL
    A0A0A0MQE0
    Related
    ENSMUSP00000107057.5, ENSMUST00000111429.11
    Conserved Domains (2) summary
    smart00352
    Location:281 → 355
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:385 → 439
    Homeobox; Homeobox domain

  4. XM_036162785.1 → XP_036018678.1  POU domain, class 2, transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    P25425, Q61994, Q63891, Q6Y681, Q7TSD0, Q8BT04, Q8K570, Q99JH0, Q9WTZ4, Q9WTZ5, Q9WTZ6
    UniProtKB/TrEMBL
    A0A0A0MQE0
    Conserved Domains (2) summary
    smart00352
    Location:281 → 355
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:385 → 439
    Homeobox; Homeobox domain

  5. XM_017319360.3 → XP_017174849.1  POU domain, class 2, transcription factor 1 isoform X2

    UniProtKB/TrEMBL
    A0A0A0MQE0
    Conserved Domains (2) summary
    smart00352
    Location:281 → 355
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:385 → 439
    Homeobox; Homeobox domain

RNA

  1. XR_373598.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25425.3 GenPept UniProtKB/Swiss-Prot:P25425

Gene LinkOut

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