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Cnot7 CCR4-NOT transcription complex, subunit 7 [ Mus musculus (house mouse) ]

Gene ID: 18983, updated on 4-May-2024

Summary

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Official Symbol
Cnot7provided by MGI
Official Full Name
CCR4-NOT transcription complex, subunit 7provided by MGI
Primary source
MGI:MGI:1298230
See related
Ensembl:ENSMUSG00000031601 AllianceGenome:MGI:1298230
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Caf1; Pop2; CAF-1
Summary
Enables poly(A)-specific ribonuclease activity. Involved in gene silencing by RNA; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; and positive regulation of nuclear-transcribed mRNA poly(A) tail shortening. Acts upstream of or within P-body assembly and positive regulation of RNA metabolic process. Located in P-body and nucleus. Part of CCR4-NOT complex. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and skeleton. Orthologous to human CNOT7 (CCR4-NOT transcription complex subunit 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E14 (RPKM 22.0), CNS E18 (RPKM 21.1) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 A4; 8 23.89 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (40945579..40968888, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (40492538..40515847, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor 20 Neighboring gene microRNA 7666 Neighboring gene mitochondrial calcium uptake family, member 3 Neighboring gene zinc finger, DHHC domain containing 2 Neighboring gene vacuolar protein sorting 37A Neighboring gene myotubularin related protein 7 Neighboring gene STARR-seq mESC enhancer starr_21271 Neighboring gene STARR-seq mESC enhancer starr_21272 Neighboring gene ADAM metallopeptidase domain 24

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dynamic Control of Dendritic mRNA Expression by CNOT7 Regulates Synaptic Efficacy and Higher Cognitive Function. McFleder RL, et al. Cell Rep, 2017 Jul 18. PMID 28723570, Free PMC Article
  2. Mobilization of Dormant Cnot7 mRNA Promotes Deadenylation of Maternal Transcripts During Mouse Oocyte Maturation. Ma J, et al. Biol Reprod, 2015 Aug. PMID 26134871, Free PMC Article
  3. Cnot7-null mice exhibit high bone mass phenotype and modulation of BMP actions. Washio-Oikawa K, et al. J Bone Miner Res, 2007 Aug. PMID 17451368
  4. Expression analysis of LacZ gene placed in the locus of Cnot7 exhibits its activity in osteoblasts in vivo and in mineralized nodules in vitro. Washio-Oikawa K, et al. J Cell Biochem, 2006 Oct 1. PMID 16639713
  5. Abnormal sperm morphology caused by defects in Sertoli cells of Cnot7 knockout mice. Ogawa T, et al. Arch Histol Cytol, 2004 Nov. PMID 15700538

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CNOT7 Outcompetes Its Paralog CNOT8 for Integration into The CCR4-NOT Complex.
    Title: CNOT7 Outcompetes Its Paralog CNOT8 for Integration into The CCR4-NOT Complex.
  2. Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability.
    Title: Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability.
  3. This study identifies CNOT7 as an important regulator of RNA transport and translation in dendrites, as well as higher cognitive function.
    Title: Dynamic Control of Dendritic mRNA Expression by CNOT7 Regulates Synaptic Efficacy and Higher Cognitive Function.
  4. study reports that a complex of BTG4 and CAF1 safeguards metaphase II arrest in mammalian eggs by deadenylating maternal mRNAs
    Title: The BTG4 and CAF1 complex prevents the spontaneous activation of eggs by deadenylating maternal mRNAs.
  5. Cnot7, a key component of deadenylation machinery, are also dormant maternal mRNAs that are recruited during oocyte maturation
    Title: Mobilization of Dormant Cnot7 mRNA Promotes Deadenylation of Maternal Transcripts During Mouse Oocyte Maturation.
  6. Collectively, our data support a model of CNOT7, TOB1, CNOT1, and RNA-binding proteins collectively exerting post-transcriptional control on a metastasis suppressive transcriptional program to drive tumor cell metastasis
    Title: Post-transcriptional Control of Tumor Cell Autonomous Metastatic Potential by CCR4-NOT Deadenylase CNOT7.
  7. MK2 phosphorylation reduces the ability of TTP to promote deadenylation by inhibiting the recruitment of CAF1 deadenylase in a mechanism that does not involve sequestration of TTP by 14-3-3.
    Title: MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibiting CAF1 deadenylase recruitment.
  8. Show that a let-7 miRNA-loaded RNA-induced silencing complex interacts with the poly(A)-binding protein and the CAF1 and CCR4 deadenylases for miRNA mediated deadenylation.
    Title: Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.
  9. Gene deletion of Cnot7 caused abnormal sperm morphology in Sertoli cells from knockout mice.
    Title: Abnormal sperm morphology caused by defects in Sertoli cells of Cnot7 knockout mice.
  10. Cnot7 is expressed in osteoblasts and is associated with mineralization.
    Title: Expression analysis of LacZ gene placed in the locus of Cnot7 exhibits its activity in osteoblasts in vivo and in mineralized nodules in vitro.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(A)-specific ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A)-specific ribonuclease activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables poly(A)-specific ribonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within P-body assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within deadenylation-dependent decapping of nuclear-transcribed mRNA IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within deadenylation-dependent decapping of nuclear-transcribed mRNA IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within nuclear-transcribed mRNA poly(A) tail shortening IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
  
involved_in regulatory ncRNA-mediated gene silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of CCR4-NOT complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of CCR4-NOT complex ISO
Inferred from Sequence Orthology
more info
  
part_of CCR4-NOT core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in P-body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in intracellular non-membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
CCR4-NOT transcription complex subunit 7
Names
CCR4-associated factor 1
POP2 homolog
catabolite repressor protein (CCR4)-associative factor 1
NP_001258471.1
NP_001258472.1
NP_001348867.1
NP_001348868.1
NP_035265.1
XP_006509370.1
XP_036009723.1
XP_036009724.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271542.1 → NP_001258471.1  CCR4-NOT transcription complex subunit 7 isoform 1

    See identical proteins and their annotated locations for NP_001258471.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode the same isoform (1).
    Source sequence(s)
    AC118012, AK135669, AK147048
    Consensus CDS
    CCDS22253.1
    UniProtKB/Swiss-Prot
    Q60809
    UniProtKB/TrEMBL
    Q3V231, Q543X5
    Related
    ENSMUSP00000122933.2, ENSMUST00000132032.8
    Conserved Domains (1) summary
    cl23804
    Location:1 → 279
    CAF1; CAF1 family ribonuclease

  2. NM_001271543.1 → NP_001258472.1  CCR4-NOT transcription complex subunit 7 isoform 2

    See identical proteins and their annotated locations for NP_001258472.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
    Source sequence(s)
    AC118012
    Consensus CDS
    CCDS72114.1
    UniProtKB/TrEMBL
    Q3TLK9, Q3V231
    Related
    ENSMUSP00000119319.2, ENSMUST00000135269.8
    Conserved Domains (1) summary
    cl23804
    Location:1 → 215
    CAF1; CAF1 family ribonuclease

  3. NM_001361938.1 → NP_001348867.1  CCR4-NOT transcription complex subunit 7 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC118012, AK147048, CN663584
    Consensus CDS
    CCDS22253.1
    UniProtKB/Swiss-Prot
    Q60809
    UniProtKB/TrEMBL
    Q3V231, Q543X5
    Related
    ENSMUSP00000117304.2, ENSMUST00000149992.2
    Conserved Domains (1) summary
    cl23804
    Location:1 → 279
    CAF1; CAF1 family ribonuclease

  4. NM_001361939.1 → NP_001348868.1  CCR4-NOT transcription complex subunit 7 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC118012, AK147048, CJ166755
    UniProtKB/TrEMBL
    Q3V231
    Conserved Domains (1) summary
    cl23804
    Location:1 → 292
    CAF1; CAF1 family ribonuclease

  5. NM_011135.5 → NP_035265.1  CCR4-NOT transcription complex subunit 7 isoform 1

    See identical proteins and their annotated locations for NP_035265.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform . Variants 1, 2 and 4 encode the same isoform (1).
    Source sequence(s)
    AC118012, AK147048, CJ166755
    Consensus CDS
    CCDS22253.1
    UniProtKB/Swiss-Prot
    Q60809
    UniProtKB/TrEMBL
    Q3V231, Q543X5
    Related
    ENSMUSP00000034012.4, ENSMUST00000034012.10
    Conserved Domains (1) summary
    cl23804
    Location:1 → 279
    CAF1; CAF1 family ribonuclease

RNA

  1. NR_155265.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC118012, AK147048, CJ166755, CN663584, DV653062

  2. NR_155266.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC118012, AK147048, CN663584, DV653062

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    40945579..40968888 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153830.1 → XP_036009723.1  CCR4-NOT transcription complex subunit 7 isoform X1

    UniProtKB/TrEMBL
    Q3V231
    Conserved Domains (1) summary
    cl23804
    Location:1 → 228
    CAF1; CAF1 family ribonuclease

  2. XM_036153831.1 → XP_036009724.1  CCR4-NOT transcription complex subunit 7 isoform X2

    UniProtKB/TrEMBL
    Q3TLK9, Q3V231
    Conserved Domains (1) summary
    cl23804
    Location:1 → 215
    CAF1; CAF1 family ribonuclease

  3. XM_006509307.3 → XP_006509370.1  CCR4-NOT transcription complex subunit 7 isoform X3

    Conserved Domains (1) summary
    cl23804
    Location:1 → 173
    CAF1; CAF1 family ribonuclease

RNA

  1. XR_378909.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60809.1 GenPept UniProtKB/Swiss-Prot:Q60809

Gene LinkOut

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