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Pold2 polymerase (DNA directed), delta 2, regulatory subunit [ Mus musculus (house mouse) ]

Gene ID: 18972, updated on 5-Mar-2024

Summary

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Official Symbol
Pold2provided by MGI
Official Full Name
polymerase (DNA directed), delta 2, regulatory subunitprovided by MGI
Primary source
MGI:MGI:1097163
See related
Ensembl:ENSMUSG00000020471 AllianceGenome:MGI:1097163
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p50; 50kDa; po1D2
Summary
Predicted to enable DNA binding activity. Involved in DNA biosynthetic process. Part of delta DNA polymerase complex. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and immune system. Orthologous to human POLD2 (DNA polymerase delta 2, accessory subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 221.0), mammary gland adult (RPKM 85.3) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 A1; 11 3.88 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (5822180..5828256, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (5872180..5878256, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene phosphoglycerate mutase 2 Neighboring gene STARR-positive B cell enhancer ABC_E9815 Neighboring gene STARR-seq mESC enhancer starr_28443 Neighboring gene polymerase (DNA directed), mu Neighboring gene AE binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E6946 Neighboring gene predicted gene, 53664 Neighboring gene myosin, light polypeptide 7, regulatory Neighboring gene glucokinase Neighboring gene predicted gene 11967

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Early embryonic lethality of mice lacking POLD2. Wu X, et al. Mol Reprod Dev, 2023 Feb. PMID 36528861, Free PMC Article
  2. Identification of Pold2 as a novel interaction partner of protein inhibitor of activated STAT2. Zheng Y, et al. Int J Mol Med, 2012 Oct. PMID 22824807
  3. Cloning, chromosomal localization, and interspecies interaction of mouse DNA polymerase delta small subunit (PolD2). Hindges R, et al. Genomics, 1997 Aug 15. PMID 9286699
  4. Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen. Liu L, et al. J Biol Chem, 2003 Mar 21. PMID 12522211
  5. Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta. Ducoux M, et al. J Biol Chem, 2001 Dec 28. PMID 11595739

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Early embryonic lethality of mice lacking POLD2.
    Title: Early embryonic lethality of mice lacking POLD2.
  2. A direct interaction between Pold2 and PIAS2 was confirmed by direct yeast two-hybrid.
    Title: Identification of Pold2 as a novel interaction partner of protein inhibitor of activated STAT2.
  3. The association of PDIP38 with pol delta was shown to occur in calf thymus tissue and mammalian cell extracts by GST-PDIP38 pull-down and coimmunoprecipitation experiments.
    Title: Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA strand elongation involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA-templated DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in error-prone translesion synthesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of delta DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of delta DNA polymerase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of delta DNA polymerase complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of zeta DNA polymerase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA polymerase delta subunit 2
Names
DNA polymerase delta subunit p50
NP_001348871.1
NP_032920.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361942.1 → NP_001348871.1  DNA polymerase delta subunit 2

    Status: VALIDATED

    Source sequence(s)
    AL627069, AV329456, BM946479, BQ840484, CX565680
    Consensus CDS
    CCDS24407.1
    UniProtKB/Swiss-Prot
    O35654, Q99J61
    Conserved Domains (1) summary
    cd07387
    Location:215 → 452
    MPP_PolD2_C; PolD2 (DNA polymerase delta, subunit 2), C-terminal domain

  2. NM_008894.2 → NP_032920.2  DNA polymerase delta subunit 2

    See identical proteins and their annotated locations for NP_032920.2

    Status: VALIDATED

    Source sequence(s)
    BG078511, BM215242, BY093766, BY668936, CB205181
    Consensus CDS
    CCDS24407.1
    UniProtKB/Swiss-Prot
    O35654, Q99J61
    Related
    ENSMUSP00000099986.4, ENSMUST00000102922.10
    Conserved Domains (1) summary
    cd07387
    Location:215 → 452
    MPP_PolD2_C; PolD2 (DNA polymerase delta, subunit 2), C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    5822180..5828256 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35654.2 GenPept UniProtKB/Swiss-Prot:O35654

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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