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Pnmt phenylethanolamine-N-methyltransferase [ Mus musculus (house mouse) ]

Gene ID: 18948, updated on 9-Dec-2024

Summary

Official Symbol
Pnmtprovided by MGI
Official Full Name
phenylethanolamine-N-methyltransferaseprovided by MGI
Primary source
MGI:MGI:97724
See related
Ensembl:ENSMUSG00000038216 AllianceGenome:MGI:97724
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pent
Summary
Enables phenylethanolamine N-methyltransferase activity. Predicted to be involved in epinephrine biosynthetic process and norepinephrine metabolic process. Predicted to be located in axon; dendrite; and perikaryon. Predicted to be active in cytosol. Is expressed in several structures, including adrenal gland; brain; gonad; and metanephros. Human ortholog(s) of this gene implicated in Alzheimer's disease; hypertension; and multiple sclerosis. Orthologous to human PNMT (phenylethanolamine N-methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Restricted expression toward adrenal adult (RPKM 262.6) See more
Orthologs
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Genomic context

See Pnmt in Genome Data Viewer
Location:
11 D; 11 61.75 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98277449..98279006)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98386623..98388180)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7056 Neighboring gene StAR related lipid transfer domain containing 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98254740-98254849 Neighboring gene titin-cap Neighboring gene post-GPI attachment to proteins 3 Neighboring gene STARR-seq mESC enhancer starr_30667 Neighboring gene erb-b2 receptor tyrosine kinase 2 Neighboring gene migration and invasion enhancer 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in epinephrine biosynthetic process  
involved_in epinephrine biosynthetic process  
involved_in methylation  
involved_in norepinephrine metabolic process  
Component Evidence Code Pubs
located_in axon  
is_active_in cytosol  
located_in dendrite  
located_in neuronal cell body  
located_in perikaryon  
located_in terminal bouton  
located_in varicosity  

General protein information

Preferred Names
phenylethanolamine N-methyltransferase
Names
PNMTase
noradrenaline N-methyltransferase
NP_032916.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008890.3NP_032916.1  phenylethanolamine N-methyltransferase

    See identical proteins and their annotated locations for NP_032916.1

    Status: VALIDATED

    Source sequence(s)
    AL591390
    Consensus CDS
    CCDS25347.1
    UniProtKB/Swiss-Prot
    P40935
    UniProtKB/TrEMBL
    Q0VB50
    Related
    ENSMUSP00000035549.8, ENSMUST00000041301.8
    Conserved Domains (1) summary
    pfam01234
    Location:25290
    NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    98277449..98279006
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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