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hsp-12.1 SHSP domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 188710, updated on 23-Nov-2023

Summary

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Gene symbol
hsp-12.1
Gene description
SHSP domain-containing protein
Primary source
WormBase:WBGene00011906
Locus tag
CELE_T22A3.2
See related
AllianceGenome:WB:WBGene00011906
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Located in striated muscle dense body. Is expressed in body wall musculature. Orthologous to several human genes including HSPB2 (heat shock protein family B (small) member 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: I
Exon count:
2
Sequence:
Chromosome: I; NC_003279.8 (10581538..10582615, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Regulator of telomere elongation helicase 1 homolog Neighboring gene Glutaredoxin domain-containing protein;TCTP domain-containing protein Neighboring gene ncRNA Neighboring gene Lateral Signaling Target Neighboring gene Histone-lysine N-methyltransferase set-18 Neighboring gene ncRNA Neighboring gene tRNA-Gly

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The effect of high strength static magnetic fields and ionizing radiation on gene expression and DNA damage in Caenorhabditis elegans. Kimura T, et al. Bioelectromagnetics, 2008 Dec. PMID 18512716
  2. The small heat shock proteins of the nematode Caenorhabditis elegans: structure, regulation and biology. Candido EP. Prog Mol Subcell Biol, 2002. PMID 11908066
  3. Crosstalk between the EGFR and LIN-12/Notch pathways in C. elegans vulval development. Yoo AS, et al. Science, 2004 Jan 30. PMID 14752159
  4. A Differentiation Transcription Factor Establishes Muscle-Specific Proteostasis in Caenorhabditis elegans. Bar-Lavan Y, et al. PLoS Genet, 2016 Dec. PMID 28036392, Free PMC Article
  5. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to heat IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in striated muscle dense body HDA PubMed 

General protein information

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Preferred Names
SHSP domain-containing protein
NP_001076613.1
  • Confirmed by transcript evidence
NP_001076614.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    10581538..10582615 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001083144.2 → NP_001076613.1  SHSP domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001076613.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O01263
    Conserved Domains (1) summary
    cd06526
    Location:26 → 108
    metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...

  2. NM_001083145.4 → NP_001076614.1  SHSP domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001076614.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EE65
    Conserved Domains (1) summary
    cd06526
    Location:26 → 111
    metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...
Nucleotide Protein
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