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Plxna2 plexin A2 [ Mus musculus (house mouse) ]

Gene ID: 18845, updated on 9-Dec-2024

Summary

Official Symbol
Plxna2provided by MGI
Official Full Name
plexin A2provided by MGI
Primary source
MGI:MGI:107684
See related
Ensembl:ENSMUSG00000026640 AllianceGenome:MGI:107684
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
OCT; Plxn2; PlexA2; mKIAA0463; 2810428A13Rik
Summary
Enables identical protein binding activity and semaphorin receptor activity. Involved in several processes, including chordate embryonic development; limb bud formation; and semaphorin-plexin signaling pathway. Acts upstream of or within cell surface receptor signaling pathway; centrosome localization; and cerebellar granule cell precursor tangential migration. Located in plasma membrane. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; heart; and peripheral nervous system. Orthologous to human PLXNA2 (plexin A2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in CNS E14 (RPKM 20.1), whole brain E14.5 (RPKM 19.4) and 25 other tissues See more
Orthologs
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Genomic context

See Plxna2 in Genome Data Viewer
Location:
1 H6; 1 98.27 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (194302020..194499177)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (194619791..194816869)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31988 Neighboring gene predicted gene, 51784 Neighboring gene STARR-seq mESC enhancer starr_03492 Neighboring gene STARR-seq mESC enhancer starr_03493 Neighboring gene STARR-seq mESC enhancer starr_03494 Neighboring gene STARR-seq mESC enhancer starr_03495 Neighboring gene STARR-seq mESC enhancer starr_03496 Neighboring gene STARR-seq mESC enhancer starr_03498 Neighboring gene predicted gene, 46202 Neighboring gene prefoldin subunit 1-like Neighboring gene microRNA 3962

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding PubMed 
enables protein binding PubMed 
enables semaphorin receptor activity  
enables semaphorin receptor activity PubMed 
enables semaphorin receptor activity PubMed 
enables semaphorin receptor activity PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix PubMed 
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in plasma membrane  
part_of semaphorin receptor complex  

General protein information

Preferred Names
plexin-A2
Names
plex 2
plexin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008882.2NP_032908.2  plexin-A2 precursor

    See identical proteins and their annotated locations for NP_032908.2

    Status: VALIDATED

    Source sequence(s)
    AA289826, AC162447, BC068155, BY753209, D86949
    Consensus CDS
    CCDS35827.1
    UniProtKB/Swiss-Prot
    P70207, Q6NVE6, Q6PHN4, Q80TZ7, Q8R1I4
    Related
    ENSMUSP00000027952.6, ENSMUST00000027952.12
    Conserved Domains (7) summary
    cd11272
    Location:38552
    Sema_plexin_A2; The Sema domain, a protein interacting module, of Plexin A2
    cd01179
    Location:9541037
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:858953
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01181
    Location:10411141
    IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:806855
    PSI; Plexin repeat
    pfam01833
    Location:11431227
    TIG; IPT/TIG domain
    pfam08337
    Location:13111864
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    194302020..194499177
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497240.5XP_006497303.1  plexin-A2 isoform X1

    Conserved Domains (9) summary
    cd11272
    Location:38552
    Sema_plexin_A2; The Sema domain, a protein interacting module, of Plexin A2
    cd01179
    Location:9541037
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:858953
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01181
    Location:10411141
    IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:806855
    PSI; Plexin repeat
    pfam01833
    Location:11431227
    TIG; IPT/TIG domain
    pfam08337
    Location:13111870
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:566654
    TIG_plexin; TIG domain
    pfam18020
    Location:708802
    TIG_2; TIG domain found in plexin
  2. XM_036162782.1XP_036018675.1  plexin-A2 isoform X2

    Conserved Domains (4) summary
    cd11272
    Location:38552
    Sema_plexin_A2; The Sema domain, a protein interacting module, of Plexin A2
    pfam01437
    Location:806855
    PSI; Plexin repeat
    pfam17960
    Location:565654
    TIG_plexin; TIG domain
    pfam18020
    Location:708802
    TIG_2; TIG domain found in plexin

RNA

  1. XR_373891.5 RNA Sequence

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