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Plcg1 phospholipase C, gamma 1 [ Mus musculus (house mouse) ]

Gene ID: 18803, updated on 21-Apr-2024

Summary

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Official Symbol
Plcg1provided by MGI
Official Full Name
phospholipase C, gamma 1provided by MGI
Primary source
MGI:MGI:97615
See related
Ensembl:ENSMUSG00000016933 AllianceGenome:MGI:97615
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cded; Plc-1; Plcg-1; Plc-gamma1
Summary
Enables glutamate receptor binding activity; phosphatidylinositol phospholipase C activity; and receptor tyrosine kinase binding activity. Involved in modulation of chemical synaptic transmission. Acts upstream of or within T cell receptor signaling pathway and in utero embryonic development. Located in Schaffer collateral - CA1 synapse; cell-cell junction; and glutamatergic synapse. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; integumental system; and nervous system. Orthologous to human PLCG1 (phospholipase C gamma 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 43.6), CNS E14 (RPKM 34.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H2; 2 80.97 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (160573230..160617680)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (160731310..160775760)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 57688 Neighboring gene STARR-positive B cell enhancer ABC_E646 Neighboring gene STARR-seq mESC enhancer starr_06260 Neighboring gene STARR-seq mESC enhancer starr_06261 Neighboring gene topoisomerase (DNA) I Neighboring gene predicted gene, 54128 Neighboring gene STARR-seq mESC enhancer starr_06265 Neighboring gene zinc fingers and homeoboxes 3 Neighboring gene STARR-positive B cell enhancer ABC_E6012 Neighboring gene predicted gene, 35129 Neighboring gene lipin 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dipeptide Mimetics of Different NGF and BDNF Loops Activate PLC-γ1. Gudasheva TA, et al. Dokl Biochem Biophys, 2020 Sep. PMID 33119826
  2. Host phospholipase C-γ1 impairs phagocytosis and killing of mycobacteria by J774A.1 murine macrophages. Paroha R, et al. Microbiol Immunol, 2020 Oct. PMID 32816349
  3. The function of PLCγ1 in developing mouse mDA system. Kang DS, et al. Adv Biol Regul, 2020 Jan. PMID 31558431
  4. Phospholipase Cγ1 is required for normal irritant contact dermatitis responses and sebaceous gland homeostasis. Fukuyama T, et al. Exp Dermatol, 2019 Sep. PMID 31338881
  5. Phospholipase Cγ1 is required for pre-TCR signal transduction and pre-T cell development. Fu G, et al. Eur J Immunol, 2017 Jan. PMID 27759161, Free PMC Article

See all (201) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PLCgamma1 in dopamine neurons critically regulates striatal dopamine release via VMAT2 and synapsin III.
    Title: PLCγ1 in dopamine neurons critically regulates striatal dopamine release via VMAT2 and synapsin III.
  2. Endothelial VEGFR2-PLCgamma signaling regulates vascular permeability and antitumor immunity through eNOS/Src.
    Title: Endothelial VEGFR2-PLCγ signaling regulates vascular permeability and antitumor immunity through eNOS/Src.
  3. Loss of phospholipase Cgamma1 suppresses hepatocellular carcinogenesis through blockade of STAT3-mediated cancer development.
    Title: Loss of phospholipase Cγ1 suppresses hepatocellular carcinogenesis through blockade of STAT3-mediated cancer development.
  4. Erythroid Differentiation Regulator 1 Strengthens TCR Signaling by Enhancing PLCgamma1 Signal Transduction Pathway.
    Title: Erythroid Differentiation Regulator 1 Strengthens TCR Signaling by Enhancing PLCγ1 Signal Transduction Pathway.
  5. Carbon monoxide enhances calcium transients and glucose-stimulated insulin secretion from pancreatic beta-cells by activating Phospholipase C signal pathway in diabetic mice.
    Title: Carbon monoxide enhances calcium transients and glucose-stimulated insulin secretion from pancreatic β-cells by activating Phospholipase C signal pathway in diabetic mice.
  6. Phospholipase Cgamma1 represses colorectal cancer growth by inhibiting the Wnt/beta-catenin signaling axis.
    Title: Phospholipase Cγ1 represses colorectal cancer growth by inhibiting the Wnt/β-catenin signaling axis.
  7. Modulation of calcium signaling depends on the oligosaccharide of GM1 in Neuro2a mouse neuroblastoma cells.
    Title: Modulation of calcium signaling depends on the oligosaccharide of GM1 in Neuro2a mouse neuroblastoma cells.
  8. Phosphorylation of PLCgamma1 by EphA2 Receptor Tyrosine Kinase Promotes Tumor Growth in Lung Cancer.
    Title: Phosphorylation of PLCγ1 by EphA2 Receptor Tyrosine Kinase Promotes Tumor Growth in Lung Cancer.
  9. MCAM/CD146 Signaling via PLCgamma1 Leads to Activation of beta1-Integrins in Memory T-Cells Resulting in Increased Brain Infiltration.
    Title: MCAM/CD146 Signaling via PLCγ1 Leads to Activation of β(1)-Integrins in Memory T-Cells Resulting in Increased Brain Infiltration.
  10. Host phospholipase C-gamma1 impairs phagocytosis and killing of mycobacteria by J774A.1 murine macrophages.
    Title: Host phospholipase C-γ1 impairs phagocytosis and killing of mycobacteria by J774A.1 murine macrophages.
Submit: New GeneRIF Correction See all GeneRIFs (96)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: Zhx3

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent phospholipase C activity ISO
Inferred from Sequence Orthology
more info
  
enables glutamate receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables insulin receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables neurotrophin TRKA receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol phospholipase C activity EXP
Inferred from Experiment
more info
 PubMed 
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol phospholipase C activity ISO
Inferred from Sequence Orthology
more info
  
enables phospholipase C activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phospholipase C activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables receptor tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within T cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in calcium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to epidermal growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inositol trisphosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in inositol trisphosphate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of epithelial cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vascular endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to curcumin ISO
Inferred from Sequence Orthology
more info
  
involved_in response to organonitrogen compound ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of COP9 signalosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cell projection ISO
Inferred from Sequence Orthology
more info
  
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in ruffle ISO
Inferred from Sequence Orthology
more info
  
is_active_in ruffle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Names
PLC-gamma-1
cell differentiation and embryonic development
phosphoinositide phospholipase C-gamma-1
NP_067255.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021280.3 → NP_067255.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

    See identical proteins and their annotated locations for NP_067255.2

    Status: PROVISIONAL

    Source sequence(s)
    AL590389
    Consensus CDS
    CCDS16996.1
    UniProtKB/Swiss-Prot
    Q62077, Q6P1G1
    UniProtKB/TrEMBL
    A2A4A6
    Related
    ENSMUSP00000099404.2, ENSMUST00000103115.8
    Conserved Domains (10) summary
    smart00149
    Location:954 → 1069
    PLCYc; Phospholipase C, catalytic domain (part); domain Y
    cd00275
    Location:1087 → 1211
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:319 → 466
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:663 → 765
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:545 → 649
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11970
    Location:791 → 850
    SH3_PLCgamma1; Src homology 3 domain of Phospholipase C (PLC) gamma 1
    cd13234
    Location:864 → 933
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd13362
    Location:29 → 151
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    pfam00169
    Location:71 → 142
    PH; PH domain
    cl17171
    Location:489 → 523
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    160573230..160617680
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62077.2 GenPept UniProtKB/Swiss-Prot:Q62077

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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