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Plcd4 phospholipase C, delta 4 [ Mus musculus (house mouse) ]

Gene ID: 18802, updated on 21-Apr-2024

Summary

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Official Symbol
Plcd4provided by MGI
Official Full Name
phospholipase C, delta 4provided by MGI
Primary source
MGI:MGI:107469
See related
Ensembl:ENSMUSG00000026173 AllianceGenome:MGI:107469
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4921507K24Rik
Summary
Predicted to enable G-protein alpha-subunit binding activity; guanyl-nucleotide exchange factor activity; and phosphatidylinositol phospholipase C activity. Acts upstream of or within acrosome reaction. Predicted to be located in cytosol; endoplasmic reticulum; and plasma membrane. Is expressed in nervous system and testis. Orthologous to human PLCD4 (phospholipase C delta 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 22.6), cerebellum adult (RPKM 4.2) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 C4; 1 38.54 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (74581175..74605137)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (74541975..74565977)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene villin 1 Neighboring gene ubiquitin specific peptidase 37 Neighboring gene STARR-positive B cell enhancer mm9_chr1:74552349-74552650 Neighboring gene CCR4-NOT transcription complex, subunit 9 Neighboring gene zinc finger protein 142 Neighboring gene STARR-seq mESC enhancer starr_01339 Neighboring gene STARR-positive B cell enhancer ABC_E791 Neighboring gene BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Disruption of phospholipase Cdelta4 gene modulates the liver regeneration in cooperation with nuclear protein kinase C. Akutagawa A, et al. J Biochem, 2006 Nov. PMID 16998201
  2. Phospholipase Cdelta4: from genome structure to physiological function. Fukami K, et al. Adv Enzyme Regul, 2003. PMID 12791385
  3. Phospholipase Cdelta4 is required for Ca2+ mobilization essential for acrosome reaction in sperm. Fukami K, et al. J Cell Biol, 2003 Apr 14. PMID 12695499, Free PMC Article
  4. Growth factor-induced promoter activation of murine phospholipase C delta4 gene. Fukami K, et al. Eur J Biochem, 2000 Jan. PMID 10601847
  5. Phospholipase C δ4 regulates cold sensitivity in mice. Yudin Y, et al. J Physiol, 2016 Jul 1. PMID 27062607, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We identify PLCdelta4 as a PLC isoform important in the regulation of TRPM8 both at the cellular level and in vivo
    Title: Phospholipase C δ4 regulates cold sensitivity in mice.
  2. These findings highlight a novel pathway by which nuclear PLCs affect insulin secretion and identify PPARgamma as a novel molecular target of nuclear PLCs.
    Title: Nuclear PLCs affect insulin secretion by targeting PPARγ in pancreatic β cells.
  3. PLCd4 is required for the acrosome reaction in fertilization.
    Title: Physiological functions of phospholipase C delta-type.
  4. PLCdelta(1) and PLCdelta(4) are probably differentially regulated in distinct cellular compartments by PI(4,5)P(2) and the PH domain of PLCdelta(4) does not act as a localization signal
    Title: The pleckstrin homology domain of phosphoinositide-specific phospholipase Cdelta4 is not a critical determinant of the membrane localization of the enzyme.
  5. PLCd4 has a role in the zona pellucida-induced acrosome reaction in mice
    Title: Phospholipase Cdelta4: from genome structure to physiological function.
  6. It is concluded that PLC delta4 regulates the liver regeneration in cooperation with nuclear PKC alpha and epsilon
    Title: Disruption of phospholipase Cdelta4 gene modulates the liver regeneration in cooperation with nuclear protein kinase C.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol phospholipase C activity ISO
Inferred from Sequence Orthology
more info
  
enables phospholipase C activity TAS
Traceable Author Statement
more info
 PubMed 
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within acrosome reaction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphatidylinositol metabolic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in small GTPase-mediated signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
Names
PLC-delta-4
phosphoinositide phospholipase C-delta-4
NP_001074925.1
NP_683739.2
XP_006495846.1
XP_006495847.1
XP_006495848.1
XP_006495850.1
XP_006495851.1
XP_006495852.1
XP_017174835.1
XP_036018673.1
XP_036018674.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081456.1 → NP_001074925.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter protein (isoform 1).
    Source sequence(s)
    AC117610
    Consensus CDS
    CCDS35617.1
    UniProtKB/Swiss-Prot
    Q8K3R3
    Related
    ENSMUSP00000109376.2, ENSMUST00000113747.8
    Conserved Domains (8) summary
    cd00275
    Location:639 → 764
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    PLN02228
    Location:207 → 752
    PLN02228; Phosphoinositide phospholipase C
    pfam00169
    Location:17 → 123
    PH; PH domain
    pfam09279
    Location:207 → 289
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:143 → 199
    EF-hand_7; EF-hand domain pair
    pfam14788
    Location:153 → 202
    EF-hand_10; EF hand
    cl14615
    Location:289 → 609
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:18 → 133
    PH-like; Pleckstrin homology-like domain

  2. NM_148937.2 → NP_683739.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform 2

    See identical proteins and their annotated locations for NP_683739.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and includes an alternate in-frame exon in the coding region compared to variant 1. The resulting protein (isoform 2) is longer but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC117610
    Consensus CDS
    CCDS35616.1
    UniProtKB/Swiss-Prot
    Q3USN9, Q6NZF7, Q8CAB1, Q8K3R3, Q9CUC1
    Related
    ENSMUSP00000027362.8, ENSMUST00000027362.14
    Conserved Domains (4) summary
    PLN02228
    Location:207 → 784
    PLN02228; Phosphoinositide phospholipase C
    pfam14788
    Location:153 → 202
    EF-hand_10; EF hand
    cl14615
    Location:289 → 641
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:18 → 133
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    74581175..74605137
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495787.5 → XP_006495850.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X2

    Conserved Domains (4) summary
    PLN02228
    Location:207 → 772
    PLN02228; Phosphoinositide phospholipase C
    cd13363
    Location:18 → 133
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    pfam14788
    Location:153 → 202
    EF-hand_10; EF hand
    cl14615
    Location:289 → 640
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

  2. XM_006495785.5 → XP_006495848.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1

    See identical proteins and their annotated locations for XP_006495848.1

    Conserved Domains (4) summary
    PLN02228
    Location:207 → 773
    PLN02228; Phosphoinositide phospholipase C
    cd13363
    Location:18 → 133
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    pfam14788
    Location:153 → 202
    EF-hand_10; EF hand
    cl14615
    Location:289 → 641
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

  3. XM_006495783.5 → XP_006495846.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1

    See identical proteins and their annotated locations for XP_006495846.1

    Conserved Domains (4) summary
    PLN02228
    Location:207 → 773
    PLN02228; Phosphoinositide phospholipase C
    cd13363
    Location:18 → 133
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    pfam14788
    Location:153 → 202
    EF-hand_10; EF hand
    cl14615
    Location:289 → 641
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

  4. XM_036162781.1 → XP_036018674.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X6

    Conserved Domains (4) summary
    PLN02228
    Location:207 → 740
    PLN02228; Phosphoinositide phospholipase C
    pfam14788
    Location:153 → 202
    EF-hand_10; EF hand
    cl14615
    Location:289 → 608
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:18 → 133
    PH-like; Pleckstrin homology-like domain

  5. XM_036162780.1 → XP_036018673.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X4

    Conserved Domains (4) summary
    PLN02228
    Location:207 → 783
    PLN02228; Phosphoinositide phospholipase C
    pfam14788
    Location:153 → 202
    EF-hand_10; EF hand
    cl14615
    Location:289 → 640
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:18 → 133
    PH-like; Pleckstrin homology-like domain

  6. XM_006495789.5 → XP_006495852.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X5

    Conserved Domains (4) summary
    PLN02228
    Location:207 → 741
    PLN02228; Phosphoinositide phospholipase C
    pfam14788
    Location:153 → 202
    EF-hand_10; EF hand
    cl14615
    Location:289 → 609
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:18 → 133
    PH-like; Pleckstrin homology-like domain

  7. XM_006495788.5 → XP_006495851.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X3

    See identical proteins and their annotated locations for XP_006495851.1

    UniProtKB/Swiss-Prot
    Q3USN9, Q6NZF7, Q8CAB1, Q8K3R3, Q9CUC1
    Conserved Domains (4) summary
    PLN02228
    Location:207 → 784
    PLN02228; Phosphoinositide phospholipase C
    pfam14788
    Location:153 → 202
    EF-hand_10; EF hand
    cl14615
    Location:289 → 641
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:18 → 133
    PH-like; Pleckstrin homology-like domain

  8. XM_017319346.3 → XP_017174835.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X7

    Conserved Domains (4) summary
    PLN02228
    Location:207 → 751
    PLN02228; Phosphoinositide phospholipase C
    pfam14788
    Location:153 → 202
    EF-hand_10; EF hand
    cl14615
    Location:289 → 608
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:18 → 133
    PH-like; Pleckstrin homology-like domain

  9. XM_006495784.5 → XP_006495847.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1

    See identical proteins and their annotated locations for XP_006495847.1

    Conserved Domains (4) summary
    PLN02228
    Location:207 → 773
    PLN02228; Phosphoinositide phospholipase C
    cd13363
    Location:18 → 133
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    pfam14788
    Location:153 → 202
    EF-hand_10; EF hand
    cl14615
    Location:289 → 641
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

RNA

  1. XR_865222.4 RNA Sequence

  2. XR_001783208.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K3R3.2 GenPept UniProtKB/Swiss-Prot:Q8K3R3

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