Plcb1 phospholipase C, beta 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plcb1provided by MGI
Official Full Name: phospholipase C, beta 1provided by MGI
Primary source: MGI:MGI:97613
See related: Ensembl:ENSMUSG00000051177 AllianceGenome:MGI:97613
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Plcb; mKIAA0581; 3110043I21Rik
Summary: Enables lamin binding activity and phosphatidylinositol phospholipase C activity. Involved in several processes, including positive regulation of cell cycle process; regulation of cellular macromolecule biosynthetic process; and regulation of trans-synaptic signaling. Located in several cellular components, including chromatin; glutamatergic synapse; and nuclear speck. Part of protein-containing complex. Is active in GABA-ergic synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Used to study Alzheimer's disease and schizophrenia. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 12 and myelodysplastic syndrome. Orthologous to human PLCB1 (phospholipase C beta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in frontal lobe adult (RPKM 9.1), cortex adult (RPKM 8.8) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 F3; 2 65.66 cM

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (134628084..135317178)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (134786164..135475258)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Conformational alteration in glycan induces phospholipase Cbeta1 activation and angiogenesis.
Title: Conformational alteration in glycan induces phospholipase Cβ1 activation and angiogenesis.
Cell-autonomous PLCbeta1 modulation of neural stem/progenitor cell proliferation during adult hippocampal neurogenesis.
Title: Cell-autonomous PLCβ1 modulation of neural stem/progenitor cell proliferation during adult hippocampal neurogenesis.
Activation of PLCbeta1 enhances endocannabinoid mobilization to restore hippocampal spike-timing-dependent potentiation and contextual fear memory impaired by Alzheimer's amyloidosis.
Title: Activation of PLCβ1 enhances endocannabinoid mobilization to restore hippocampal spike-timing-dependent potentiation and contextual fear memory impaired by Alzheimer's amyloidosis.
The present study showed that PLC-beta1 was crucial for beta-cell function by generation of each PLC-beta conditional knockout mouse. Mice lacking PLC-beta1 in beta cells exhibited a marked defect in glucose-stimulated insulin secretion, leading to glucose intolerance.
Title: Phospholipase C-β1 potentiates glucose-stimulated insulin secretion.
Phospholipase C-Beta1 reduction leads to disturbances to beta and gamma oscillatory dynamics and pre-pulse inhibition behavior in an animal model of schizophrenia.
Title: High-Frequency Neuronal Oscillatory Abnormalities in the Phospholipase C-β1 Knockout Mouse Model of Schizophrenia.
Data show that phospholipase C (PLC)-beta1 (PLC-beta1) overexpression determines an increase in beta-catenin translocation and that PLC-beta1, inositol polyphosphate multikinase (IPMK) and beta-catenin are mediators of the same signaling pathway.
Title: IPMK and β-catenin mediate PLC-β1-dependent signaling in myogenic differentiation.
functions in plasma membrane remodeling, particularly caveolae formation
Title: Phospholipase Cβ1 induces membrane tubulation and is involved in caveolae formation.
Plcb1 plays a crucial role in the initiation of the genetic program responsible for muscle differentiation and osteogenesis. (Review)
Title: PLC-β1 and cell differentiation: An insight into myogenesis and osteogenesis.
Unpredictable chronic mild stress mice exhibited lower nucleus accumbens (NAC) shell levels of phospholipase Cbeta.
Title: Homer2 regulates alcohol and stress cross-sensitization.
Heightened PLCbeta1b activity observed in diseased myocardium contributes to pathology by PKCalpha-mediated contractile dysfunction.
Title: The atypical 'b' splice variant of phospholipase Cβ1 promotes cardiac contractile dysfunction.

Submit: New GeneRIF Correction See all GeneRIFs (43)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Transgenic (1) 1 citation
Targeted (2) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Plcb1 (e-PCR), detects polymorphism
- UniSTS:507150

D2Mit400 (e-PCR), detects polymorphism
- UniSTS:129304

Plcb1 (e-PCR), detects polymorphism
- UniSTS:532518

D2Mit191 (e-PCR), detects polymorphism
- UniSTS:129063

D2Mit208 (e-PCR), detects polymorphism
- UniSTS:129080

AI132408 (e-PCR)
- UniSTS:159041

D2Mit223 (e-PCR), detects polymorphism
- UniSTS:129099

Plcb1 (e-PCR), detects polymorphism
- UniSTS:144219

PMC123676P1 (e-PCR)
- UniSTS:270457

D3Wox22 (e-PCR)
- UniSTS:517826

D2Dcr79 (e-PCR), detects polymorphism
- UniSTS:507638

D2Dcr80 (e-PCR), detects polymorphism
- UniSTS:507639

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lamin binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphatidylinositol phospholipase C activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol phospholipase C activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol phospholipase C activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphoric diester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled acetylcholine receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G2/M transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in G2/M transition of mitotic cell cycle	NAS Non-traceable Author Statement more info	PubMed
involved_in activation of meiosis involved in egg activation	IDA Inferred from Direct Assay more info	PubMed
involved_in brain development	NAS Non-traceable Author Statement more info	PubMed
involved_in cell adhesion	IC Inferred by Curator more info	PubMed
involved_in cellular response to fluoride	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glyceraldehyde	ISO Inferred from Sequence Orthology more info
involved_in cellular response to ionomycin	ISO Inferred from Sequence Orthology more info
involved_in cellular response to vasopressin	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in erythrocyte differentiation	TAS Traceable Author Statement more info	PubMed
involved_in fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in glutamate receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inositol trisphosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in insulin receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-1-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-12-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-15-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in ion channel modulating, G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ligand-gated ion channel signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	TAS Traceable Author Statement more info	PubMed
involved_in macrophage differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in memory	IBA Inferred from Biological aspect of Ancestor more info
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of monocyte extravasation	IDA Inferred from Direct Assay more info	PubMed
involved_in oocyte maturation	NAS Non-traceable Author Statement more info	PubMed
involved_in phosphatidylinositol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of CD24 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of G1/S transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of acrosome reaction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of developmental growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-12 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of myoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of sodium:proton antiporter activity	NAS Non-traceable Author Statement more info	PubMed
involved_in postsynaptic modulation of chemical synaptic transmission	EXP Inferred from Experiment more info	PubMed
involved_in postsynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of establishment of endothelial barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of retrograde trans-synaptic signaling by endocanabinoid	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of retrograde trans-synaptic signaling by endocanabinoid	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in release of sequestered calcium ion into cytosol	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to monosaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to peptide hormone	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in myelin sheath	HDA more info	PubMed
is_active_in nuclear speck	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic cytosol	IEP Inferred from Expression Pattern more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Names: PLC-154; PLC-beta-1; phosphoinositide phospholipase C; phosphoinositide phospholipase C-beta-1; phospholipase C-beta-1a

NP_001139302.1

EC 3.1.4.11

NP_062651.2

EC 3.1.4.11

XP_006498993.1

EC 3.1.4.11

XP_036015453.1

EC 3.1.4.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145830.1 → NP_001139302.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform 1

See identical proteins and their annotated locations for NP_001139302.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK143153, AL935278, BC058710

Consensus CDS

CCDS50729.1

UniProtKB/Swiss-Prot

Q62075, Q6PDH1, Q8K5A5, Q8K5A6, Q9Z0E5, Q9Z1B3, Q9Z2T5

UniProtKB/TrEMBL

Q2M4J2

Related

ENSMUSP00000105743.2, ENSMUST00000110116.8

Conserved Domains (7) summary

cd00275
Location:677 → 796

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08591
Location:316 → 643

PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta

PLN02952
Location:216 → 784

PLN02952; phosphoinositide phospholipase C

cd13361
Location:22 → 148

PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain

pfam06631
Location:903 → 939

DUF1154; Protein of unknown function (DUF1154)

pfam08703
Location:1003 → 1172

PLC-beta_C; PLC-beta C terminal

pfam09279
Location:224 → 314

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
NM_019677.2 → NP_062651.2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform 2

See identical proteins and their annotated locations for NP_062651.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate 3' exon that contains an in-frame stop codon compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AK143153, AL935278, BC058710, BU846788

Consensus CDS

CCDS16787.1

UniProtKB/TrEMBL

Q2M4J2

Related

ENSMUSP00000118756.3, ENSMUST00000131552.5

Conserved Domains (7) summary

cd00275
Location:677 → 796

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08591
Location:316 → 643

PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta

PLN02952
Location:216 → 784

PLN02952; phosphoinositide phospholipase C

cd13361
Location:22 → 148

PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain

pfam06631
Location:903 → 939

DUF1154; Protein of unknown function (DUF1154)

pfam08703
Location:1003 → 1141

PLC-beta_C; PLC-beta C terminal

pfam09279
Location:224 → 314

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

134628084..135317178

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006498930.4 → XP_006498993.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1

UniProtKB/TrEMBL

Q2M4J2

Conserved Domains (6) summary

cd00275
Location:624 → 743

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08591
Location:263 → 590

PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta

cd13361
Location:5 → 95

PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain

cd16208
Location:100 → 250

EFh_PI-PLCbeta1; EF-hand motif found in phosphoinositide phospholipase C beta 1 (PI-PLC-beta1)

pfam06631
Location:850 → 886

DUF1154; Protein of unknown function (DUF1154)

pfam08703
Location:950 → 1119

PLC-beta_C; PLC-beta C terminal
XM_036159560.1 → XP_036015453.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2

UniProtKB/TrEMBL

Q2M4J2

Conserved Domains (5) summary

cd00275
Location:576 → 695

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08591
Location:215 → 542

PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta

cd16208
Location:52 → 202

EFh_PI-PLCbeta1; EF-hand motif found in phosphoinositide phospholipase C beta 1 (PI-PLC-beta1)

pfam08703
Location:902 → 1071

PLC-beta_C; PLC-beta C terminal

cl17171
Location:1 → 47

PH-like; Pleckstrin homology-like domain