Plaur plasminogen activator, urokinase receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plaurprovided by MGI
Official Full Name: plasminogen activator, urokinase receptorprovided by MGI
Primary source: MGI:MGI:97612
See related: Ensembl:ENSMUSG00000046223 AllianceGenome:MGI:97612
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cd87; uPAR; u-PAR
Summary: Predicted to enable enzyme binding activity; protein domain specific binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including negative regulation of apoptotic signaling pathway; positive regulation of epidermal growth factor receptor signaling pathway; and positive regulation of release of cytochrome c from mitochondria. Is integral component of plasma membrane. Is expressed in several structures, including decidua; early conceptus; and spleen. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Orthologous to human PLAUR (plasminogen activator, urokinase receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 24.3), spleen adult (RPKM 16.2) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 10.92 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (24161857..24175393)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (24460937..24475970)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of Formyl Peptide Receptors and beta-Arrestin-1 in suPAR Signal Transduction in Mouse Podocytes: Interactions with alphaVbeta3-Integrin.
Title: Role of Formyl Peptide Receptors and β-Arrestin-1 in suPAR Signal Transduction in Mouse Podocytes: Interactions with αVβ3-Integrin.
Urokinase-Type Plasminogen Activator Receptor Regulates Prosurvival and Angiogenic Properties of Cardiac Mesenchymal Stromal Cells.
Title: Urokinase-Type Plasminogen Activator Receptor Regulates Prosurvival and Angiogenic Properties of Cardiac Mesenchymal Stromal Cells.
SuPAR mediates viral response proteinuria by rapidly changing podocyte function.
Title: SuPAR mediates viral response proteinuria by rapidly changing podocyte function.
Comprehensive analysis of the diagnostic and therapeutic value of the hypoxia-related gene PLAUR in the progression of atherosclerosis.
Title: Comprehensive analysis of the diagnostic and therapeutic value of the hypoxia-related gene PLAUR in the progression of atherosclerosis.
Deficiency of Urokinase-Type Plasminogen Activator Receptor Is Associated with the Development of Perivascular Fibrosis in Mouse Heart.
Title: Deficiency of Urokinase-Type Plasminogen Activator Receptor Is Associated with the Development of Perivascular Fibrosis in Mouse Heart.
The PLAUR signaling promotes chronic pruritus.
Title: The PLAUR signaling promotes chronic pruritus.
MAGP2 induces tumor progression by enhancing uPAR-mediated cell proliferation.
Title: MAGP2 induces tumor progression by enhancing uPAR-mediated cell proliferation.
Urokinase receptor regulates nerve regeneration through its interaction with alpha5beta1-integrin.
Title: Urokinase receptor regulates nerve regeneration through its interaction with α5β1-integrin.
Urokinase-type plasminogen activator receptor is required for impairing toll-like receptor 7 signaling on macrophage efferocytosis in lupus.
Title: Urokinase-type plasminogen activator receptor is required for impairing toll-like receptor 7 signaling on macrophage efferocytosis in lupus.
Further Evidence That the Soluble Urokinase Plasminogen Activator Receptor Does Not Directly Injure Mice or Human Podocytes.
Title: Further Evidence That the Soluble Urokinase Plasminogen Activator Receptor Does Not Directly Injure Mice or Human Podocytes.

Submit: New GeneRIF Correction See all GeneRIFs (105)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (5)

General gene information

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Markers

Plaur (e-PCR), detects polymorphism
- UniSTS:144218

Plaur (e-PCR), detects polymorphism
- UniSTS:525933

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in epithelial cell differentiation involved in prostate gland development	ISO Inferred from Sequence Orthology more info
involved_in mesenchymal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA binding	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of homotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of fibrinolysis	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of plasminogen activation	NAS Non-traceable Author Statement more info	PubMed
involved_in urokinase plasminogen activator signaling pathway	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein complex involved in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
part_of serine-type endopeptidase complex	IPI Inferred from Physical Interaction more info	PubMed
part_of serine-type endopeptidase complex	ISO Inferred from Sequence Orthology more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: urokinase plasminogen activator surface receptor

Names: urokinase plasminogen activator receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011113.4 → NP_035243.1 urokinase plasminogen activator surface receptor precursor

See identical proteins and their annotated locations for NP_035243.1

Status: VALIDATED

Source sequence(s)

AC161166, AK002580, AK131951

Consensus CDS

CCDS20950.1

UniProtKB/Swiss-Prot

P35456, P35457

UniProtKB/TrEMBL

Q3U2D1, Q545X5

Related

ENSMUSP00000002284.10, ENSMUST00000002284.11

Conserved Domains (2) summary

smart00134
Location:213 → 300

LU; Ly-6 antigen / uPA receptor -like domain

pfam00021
Location:26 → 100

UPAR_LY6; u-PAR/Ly-6 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

24161857..24175393

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152789.1 → XP_036008682.1 urokinase plasminogen activator surface receptor isoform X1

UniProtKB/TrEMBL

Q3U2D1

Conserved Domains (1) summary

smart00134
Location:24 → 106

LU; Ly-6 antigen / uPA receptor -like domain