Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pla2g4aprovided by MGI
Official Full Name: phospholipase A2, group IVA (cytosolic, calcium-dependent)provided by MGI
Primary source: MGI:MGI:1195256
See related: Ensembl:ENSMUSG00000056220 AllianceGenome:MGI:1195256
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: cPLA2; Pla2g4; cPLA2alpha; cPLA2-alpha
Summary: The protein encoded by this gene is a member of the phospholipase A2 group IV family. This enzyme hydrolyzes membrane phospholipids, thereby releasing the polyunsaturated fatty acid, arachidonic acid. Arachidonic acid is further metabolized into eicosanoids such as leukotrienes, thromboxanes and prostaglandins, that play important roles in regulating diverse biological processes such as inflammatory responses, membrane and actin dynamics, and tumorigenesis. A rise in intracellular calcium levels results in binding of calcium to the C2 domain of this protein, and triggers the translocation from the cytosol to intracellular membranes, including the Golgi apparatus. Disruption of this gene in mice led to decreased levels of eicosonaoids and platelet-activating factor, decreased allergic symptoms, and impaired reproductive ability in females. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
Expression: Biased expression in bladder adult (RPKM 17.0), placenta adult (RPKM 4.1) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 G1; 1 63.51 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (149705369..149837041, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (149829618..149961290, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Skewing cPLA2alpha activity toward oxoeicosanoid production promotes neutrophil N2 polarization, wound healing, and the response to sepsis.
Title: Skewing cPLA(2)α activity toward oxoeicosanoid production promotes neutrophil N2 polarization, wound healing, and the response to sepsis.
Characterization of the binding of cytosolic phospholipase A2 alpha and NOX2 NADPH oxidase in mouse macrophages.
Title: Characterization of the binding of cytosolic phospholipase A(2) alpha and NOX2 NADPH oxidase in mouse macrophages.
Endothelial group IVA phospholipase A2 promotes hepatic fibrosis with sinusoidal capillarization in the early stage of non-alcoholic steatohepatitis in mice.
Title: Endothelial group IVA phospholipase A(2) promotes hepatic fibrosis with sinusoidal capillarization in the early stage of non-alcoholic steatohepatitis in mice.
PLA2G4A promotes right-sided colorectal cancer progression by inducing CD39+gammadelta Treg polarization.
Title: PLA2G4A promotes right-sided colorectal cancer progression by inducing CD39+γδ Treg polarization.
Cytosolic Phospholipase A2 Is Required for Fexofenadine's Therapeutic Effects against Inflammatory Bowel Disease in Mice.
Title: Cytosolic Phospholipase A2 Is Required for Fexofenadine's Therapeutic Effects against Inflammatory Bowel Disease in Mice.
The effects of myelin on macrophage activation are phenotypic specific via cPLA2 in the context of spinal cord injury inflammation.
Title: The effects of myelin on macrophage activation are phenotypic specific via cPLA(2) in the context of spinal cord injury inflammation.
A Metalloproteinase Induces an Inflammatory Response in Preadipocytes with the Activation of COX Signalling Pathways and Participation of Endogenous Phospholipases A2.
Title: A Metalloproteinase Induces an Inflammatory Response in Preadipocytes with the Activation of COX Signalling Pathways and Participation of Endogenous Phospholipases A(2).
Exposure to growth hormone is associated with hepatic up-regulation of cPLA2alpha and COX.
Title: Exposure to growth hormone is associated with hepatic up-regulation of cPLA2α and COX.
Gigantol ameliorates CCl4-induced liver injury via preventing activation of JNK/cPLA2/12-LOX inflammatory pathway.
Title: Gigantol ameliorates CCl(4)-induced liver injury via preventing activation of JNK/cPLA2/12-LOX inflammatory pathway.
PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma.
Title: PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma.

Submit: New GeneRIF Correction See all GeneRIFs (128)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (4) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent phospholipase A2 activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipase A2 activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium-dependent phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	ISO Inferred from Sequence Orthology more info
enables calcium-independent phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables ceramide 1-phosphate binding	ISO Inferred from Sequence Orthology more info
enables histone acetyltransferase binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables lysophospholipase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidyl phospholipase B activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3-phosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4-phosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-5-phosphate binding	ISO Inferred from Sequence Orthology more info
enables phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables phospholipase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in arachidonic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in arachidonic acid secretion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within arachidonic acid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to antibiotic	IDA Inferred from Direct Assay more info	PubMed
involved_in decidualization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glycerol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycerophospholipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within icosanoid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leukotriene biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leukotriene biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in monoacylglycerol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in ovulation from ovarian follicle	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine acyl-chain remodeling	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylcholine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylglycerol catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phospholipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in platelet activating factor biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T-helper 1 type immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of platelet activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of prostaglandin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vesicle fusion	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prostaglandin metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in response to organic substance	ISO Inferred from Sequence Orthology more info
involved_in surfactant homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in zymogen granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytosolic phospholipase A2

Names: Cytosolic phospholipase A2 (CPLA2); Type IV PLA2; cytosolic PLA2; phospholipase A2 group IVA; phospholipase A2, group 4

NP_001292561.1

EC 3.1.1.4

EC 3.1.1.5

NP_032895.1

EC 3.1.1.4

EC 3.1.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001305632.1 → NP_001292561.1 cytosolic phospholipase A2 isoform 2

See identical proteins and their annotated locations for NP_001292561.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AK004701, BQ033204

Consensus CDS

CCDS78700.1

UniProtKB/TrEMBL

Q9DBX5

Related

ENSMUSP00000107557.3, ENSMUST00000111926.9

Conserved Domains (3) summary

cd07200
Location:136 → 721

cPLA2_Grp-IVA; Group IVA cytosolic phospholipase A2; catalytic domain; Ca-dependent

cd04036
Location:12 → 130

C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)

smart00022
Location:109 → 660

PLAc; Cytoplasmic phospholipase A2, catalytic subunit
NM_008869.4 → NP_032895.1 cytosolic phospholipase A2 isoform 1

See identical proteins and their annotated locations for NP_032895.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC158151, BQ033204, M72394

Consensus CDS

CCDS15352.1

UniProtKB/Swiss-Prot

P47713

UniProtKB/TrEMBL

Q3UMQ1

Related

ENSMUSP00000070868.9, ENSMUST00000070200.15

Conserved Domains (2) summary

cd07200
Location:144 → 729

cPLA2_Grp-IVA; Group IVA cytosolic phospholipase A2; catalytic domain; Ca-dependent

cd04036
Location:20 → 138

C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)