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Pkig protein kinase inhibitor, gamma [ Mus musculus (house mouse) ]

Gene ID: 18769, updated on 3-Apr-2024

Summary

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Official Symbol
Pkigprovided by MGI
Official Full Name
protein kinase inhibitor, gammaprovided by MGI
Primary source
MGI:MGI:1343086
See related
Ensembl:ENSMUSG00000035268 AllianceGenome:MGI:1343086
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PKIgamma
Summary
Enables cAMP-dependent protein kinase inhibitor activity. Acts upstream of or within negative regulation of protein import into nucleus; negative regulation of protein kinase activity; and negative regulation of transcription by RNA polymerase II. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including genitourinary system; tongue; and vertebral axis musculature. Orthologous to human PKIG (cAMP-dependent protein kinase inhibitor gamma). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: partial on reference assembly
Expression
Ubiquitous expression in testis adult (RPKM 82.9), heart adult (RPKM 72.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Pkig in Genome Data Viewer
Location:
2 H3; 2 84.4 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (163500306..163568078)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (163658211..163726158)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2057 Neighboring gene tocopherol (alpha) transfer protein-like Neighboring gene RIKEN cDNA 0610039K10 gene Neighboring gene serine incorporator 3 Neighboring gene STARR-positive B cell enhancer ABC_E10159 Neighboring gene STARR-positive B cell enhancer ABC_E9208 Neighboring gene STARR-positive B cell enhancer ABC_E819 Neighboring gene STARR-seq mESC enhancer starr_06314 Neighboring gene STARR-positive B cell enhancer ABC_E2058 Neighboring gene predicted gene 16316 Neighboring gene adenosine deaminase intronic regulatory elements Neighboring gene adenosine deaminase upstream regulatory elements Neighboring gene adenosine deaminase Neighboring gene cellular communication network factor 5 Neighboring gene potassium channel, subfamily K, member 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Downregulation of cAMP-dependent protein kinase inhibitor gamma is required for BMP-2-induced osteoblastic differentiation. Zhao L, et al. Int J Biochem Cell Biol, 2006. PMID 16870489
  2. Endogenous protein kinase inhibitor gamma terminates immediate-early gene expression induced by cAMP-dependent protein kinase (PKA) signaling: termination depends on PKA inactivation rather than PKA export from the nucleus. Chen X, et al. J Biol Chem, 2005 Jan 28. PMID 15557275
  3. Protein kinase inhibitor γ reciprocally regulates osteoblast and adipocyte differentiation by downregulating leukemia inhibitory factor. Chen X, et al. Stem Cells, 2013 Dec. PMID 23963683, Free PMC Article
  4. Characterization of the mouse matrilin-4 gene: a 5' antiparallel overlap with the gene encoding the transcription factor RBP-l. Wagener R, et al. Genomics, 2001 Aug. PMID 11549321
  5. Bicc1 links the regulation of cAMP signaling in polycystic kidneys to microRNA-induced gene silencing. Piazzon N, et al. J Mol Cell Biol, 2012 Dec. PMID 22641646

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results indicate that the downregulation of PKIgamma may be prerequisite for the PKA activation during the osteoblastic differentiation of precursor cells.
    Title: Downregulation of cAMP-dependent protein kinase inhibitor gamma is required for BMP-2-induced osteoblastic differentiation.
  2. endogenous levels of PKI regulate PKA signaling
    Title: Endogenous protein kinase inhibitor gamma terminates immediate-early gene expression induced by cAMP-dependent protein kinase (PKA) signaling: termination depends on PKA inactivation rather than PKA export from the nucleus.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (3) 
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cAMP-dependent protein kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cAMP-dependent protein kinase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cAMP-dependent protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cAMP-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of protein import into nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cAMP-dependent protein kinase inhibitor gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039390.3 → NP_001034479.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    See identical proteins and their annotated locations for NP_001034479.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 4. Variants 1-5 and 7-19 all encode the same isoform (1).
    Source sequence(s)
    AL591490
    Consensus CDS
    CCDS17014.1
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    B7ZC22, Q3TP50
    Related
    ENSMUSP00000096704.3, ENSMUST00000099105.9
    Conserved Domains (1) summary
    pfam02827
    Location:2 → 70
    PKI; cAMP-dependent protein kinase inhibitor

  2. NM_001039391.2 → NP_001034480.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    See identical proteins and their annotated locations for NP_001034480.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 4. Variants 1-5 and 7-19 all encode the same isoform (1).
    Source sequence(s)
    AK164716, BY343638, BY617655, CJ051558
    Consensus CDS
    CCDS17014.1
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    B7ZC22, Q3TP50
    Related
    ENSMUSP00000068344.7, ENSMUST00000064703.13
    Conserved Domains (1) summary
    pfam02827
    Location:2 → 70
    PKI; cAMP-dependent protein kinase inhibitor

  3. NM_001164053.2 → NP_001157525.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    See identical proteins and their annotated locations for NP_001157525.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longer isoform (1). Variants 1-5 and 7-19 all encode the same isoform (1).
    Source sequence(s)
    AL591490
    Consensus CDS
    CCDS17014.1
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    B7ZC22, Q3TP50
    Related
    ENSMUSP00000120145.2, ENSMUST00000126182.8
    Conserved Domains (1) summary
    pfam02827
    Location:2 → 70
    PKI; cAMP-dependent protein kinase inhibitor

  4. NM_001164055.1 → NP_001157527.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    See identical proteins and their annotated locations for NP_001157527.1

    Status: VALIDATED

    Source sequence(s)
    AL591490
    Consensus CDS
    CCDS17014.1
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    B7ZC22, Q3TP50
    Related
    ENSMUSP00000126223.2, ENSMUST00000164399.8
    Conserved Domains (1) summary
    pfam02827
    Location:2 → 70
    PKI; cAMP-dependent protein kinase inhibitor

  5. NM_001277096.1 → NP_001264025.1  cAMP-dependent protein kinase inhibitor gamma isoform 2

    See identical proteins and their annotated locations for NP_001264025.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate in-frame splice site, compared to variant 4. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL591490
    UniProtKB/TrEMBL
    B7ZC22
    Conserved Domains (1) summary
    pfam02827
    Location:2 → 69
    PKI; cAMP-dependent protein kinase inhibitor

  6. NM_001420659.1 → NP_001407588.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591490
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    Q3TP50

  7. NM_001420660.1 → NP_001407589.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591490
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    Q3TP50

  8. NM_001420661.1 → NP_001407590.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591490
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    Q3TP50

  9. NM_001420662.1 → NP_001407591.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591490
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    Q3TP50

  10. NM_001420663.1 → NP_001407592.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591490
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    Q3TP50

  11. NM_001420664.1 → NP_001407593.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591490
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    Q3TP50

  12. NM_001420665.1 → NP_001407594.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591490
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    Q3TP50

  13. NM_001420666.1 → NP_001407595.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591490
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    Q3TP50

  14. NM_001420668.1 → NP_001407597.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591490
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    Q3TP50

  15. NM_001420669.1 → NP_001407598.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591490
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    Q3TP50

  16. NM_001420670.1 → NP_001407599.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591490
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    Q3TP50

  17. NM_001420671.1 → NP_001407600.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591490
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    Q3TP50

  18. NM_001420672.1 → NP_001407601.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591490
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    Q3TP50

  19. NM_001420673.1 → NP_001407602.1  cAMP-dependent protein kinase inhibitor gamma isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL591490

  20. NM_001420674.1 → NP_001407603.1  cAMP-dependent protein kinase inhibitor gamma isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL591490

  21. NM_001420675.1 → NP_001407604.1  cAMP-dependent protein kinase inhibitor gamma isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL591490

  22. NM_001420676.1 → NP_001407605.1  cAMP-dependent protein kinase inhibitor gamma isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL591490

  23. NM_011106.3 → NP_035236.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

    See identical proteins and their annotated locations for NP_035236.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents use of an alternate promoter and 5' UTR, compared to variant 4. Variants 1-5 and 7-19 all encode the same isoform (1).
    Source sequence(s)
    AL591490
    Consensus CDS
    CCDS17014.1
    UniProtKB/Swiss-Prot
    O70139
    UniProtKB/TrEMBL
    B7ZC22, Q3TP50
    Related
    ENSMUSP00000105027.3, ENSMUST00000109400.3
    Conserved Domains (1) summary
    pfam02827
    Location:2 → 70
    PKI; cAMP-dependent protein kinase inhibitor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    163500306..163568078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70139.1 GenPept UniProtKB/Swiss-Prot:O70139

Gene LinkOut

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