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Pkib protein kinase inhibitor beta, cAMP dependent, testis specific [ Mus musculus (house mouse) ]

Gene ID: 18768, updated on 21-Apr-2024

Summary

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Official Symbol
Pkibprovided by MGI
Official Full Name
protein kinase inhibitor beta, cAMP dependent, testis specificprovided by MGI
Primary source
MGI:MGI:101937
See related
Ensembl:ENSMUSG00000019876 AllianceGenome:MGI:101937
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pkibeta; Prkacn2
Summary
Enables cAMP-dependent protein kinase inhibitor activity. Acts upstream of or within negative regulation of cAMP-dependent protein kinase activity. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including brain; femur; gut; integumental system; and reproductive system. Orthologous to human PKIB (cAMP-dependent protein kinase inhibitor beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 8.2), cerebellum adult (RPKM 3.8) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 B4; 10 29.22 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (57508077..57617208)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (57631981..57741112)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr10:57250127-57250428 Neighboring gene STARR-seq mESC enhancer starr_26749 Neighboring gene serine incorporator 1 Neighboring gene STARR-seq mESC enhancer starr_26750 Neighboring gene ribosomal protein L48, pseudogene 1 Neighboring gene predicted gene, 18253 Neighboring gene STARR-positive B cell enhancer mm9_chr10:57463328-57463629 Neighboring gene STARR-seq mESC enhancer starr_26751 Neighboring gene peptidylprolyl isomerase A pseudogene 10_506.1 Neighboring gene fatty acid binding protein 7, brain

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Feedback inhibition of CREB signaling promotes beta cell dysfunction in insulin resistance. Blanchet E, et al. Cell Rep, 2015 Feb 24. PMID 25704817, Free PMC Article
  2. Reproductive function in protein kinase inhibitor-deficient mice. Belyamani M, et al. Mol Cell Biol, 2001 Jun. PMID 11359903, Free PMC Article
  3. The mouse Prkacn2 gene encoding protein kinase A inhibitor 2 is located on proximal chromosome 10. Scarpetta MA, et al. Mamm Genome, 1996 Dec. PMID 8995769
  4. Differential expression of mRNAs for protein kinase inhibitor isoforms in mouse brain. Seasholtz AF, et al. Proc Natl Acad Sci U S A, 1995 Feb 28. PMID 7878050, Free PMC Article
  5. Evidence for two additional isoforms of the endogenous protein kinase inhibitor of cAMP-dependent protein kinase in mouse. Scarpetta MA, et al. J Biol Chem, 1993 May 25. PMID 7684369

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cAMP-dependent protein kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cAMP-dependent protein kinase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cAMP-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of cAMP-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of telomere capping ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cAMP-dependent protein kinase inhibitor beta
Names
PKI-beta
protein kinase, cAMP-dependent, catalytic, inhibitor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039050.1 → NP_001034139.1  cAMP-dependent protein kinase inhibitor beta isoform 2

    See identical proteins and their annotated locations for NP_001034139.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2 through 6 encode the same isoform (2).
    Source sequence(s)
    AK156950, BC052351
    Consensus CDS
    CCDS23855.1
    UniProtKB/TrEMBL
    F8WGJ1, Q3TZU5, Q5M8R3
    Related
    ENSMUSP00000067532.7, ENSMUST00000066028.13
    Conserved Domains (1) summary
    pfam02827
    Location:9 → 77
    PKI; cAMP-dependent protein kinase inhibitor

  2. NM_001039051.2 → NP_001034140.1  cAMP-dependent protein kinase inhibitor beta isoform 2

    See identical proteins and their annotated locations for NP_001034140.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2 through 6 encode the same isoform (2).
    Source sequence(s)
    AC102647, AC168055, AK005281
    Consensus CDS
    CCDS23855.1
    UniProtKB/TrEMBL
    F8WGJ1, Q3TZU5, Q5M8R3
    Related
    ENSMUSP00000075374.6, ENSMUST00000075992.12
    Conserved Domains (1) summary
    pfam02827
    Location:9 → 77
    PKI; cAMP-dependent protein kinase inhibitor

  3. NM_001039052.1 → NP_001034141.1  cAMP-dependent protein kinase inhibitor beta isoform 2

    See identical proteins and their annotated locations for NP_001034141.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2 through 6 encode the same isoform (2).
    Source sequence(s)
    BC061162, CAAA01212555
    Consensus CDS
    CCDS23855.1
    UniProtKB/TrEMBL
    F8WGJ1, Q3TZU5, Q5M8R3
    Related
    ENSMUSP00000135280.2, ENSMUST00000177325.8
    Conserved Domains (1) summary
    pfam02827
    Location:9 → 77
    PKI; cAMP-dependent protein kinase inhibitor

  4. NM_001039053.2 → NP_001034142.2  cAMP-dependent protein kinase inhibitor beta isoform 2

    See identical proteins and their annotated locations for NP_001034142.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2 through 6 encode the same isoform (2).
    Source sequence(s)
    AC102647, AC168055, AK005281
    Consensus CDS
    CCDS23855.1
    UniProtKB/TrEMBL
    F8WGJ1, Q3TZU5, Q5M8R3
    Related
    ENSMUSP00000135835.2, ENSMUST00000177473.8
    Conserved Domains (1) summary
    pfam02827
    Location:9 → 77
    PKI; cAMP-dependent protein kinase inhibitor

  5. NM_001190402.1 → NP_001177331.1  cAMP-dependent protein kinase inhibitor beta isoform 2

    See identical proteins and their annotated locations for NP_001177331.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2 through 6 encode the same isoform (2).
    Source sequence(s)
    AC102647, AC168055, AK005281
    Consensus CDS
    CCDS23855.1
    UniProtKB/TrEMBL
    F8WGJ1, Q3TZU5, Q5M8R3
    Related
    ENSMUSP00000135666.2, ENSMUST00000175852.2
    Conserved Domains (1) summary
    pfam02827
    Location:9 → 77
    PKI; cAMP-dependent protein kinase inhibitor

  6. NM_008863.4 → NP_032889.3  cAMP-dependent protein kinase inhibitor beta isoform 1

    See identical proteins and their annotated locations for NP_032889.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC102647, AC168055, AK083875
    Consensus CDS
    CCDS23854.1
    UniProtKB/TrEMBL
    F7D7A9, Q8BNE5
    Related
    ENSMUSP00000093329.4, ENSMUST00000095668.10
    Conserved Domains (1) summary
    pfam02827
    Location:41 → 109
    PKI; cAMP-dependent protein kinase inhibitor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    57508077..57617208
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512602.4 → XP_006512665.1  cAMP-dependent protein kinase inhibitor beta isoform X1

    See identical proteins and their annotated locations for XP_006512665.1

    UniProtKB/TrEMBL
    F7D7A9, Q8BNE5
    Conserved Domains (1) summary
    pfam02827
    Location:41 → 109
    PKI; cAMP-dependent protein kinase inhibitor

  2. XM_017313847.3 → XP_017169336.1  cAMP-dependent protein kinase inhibitor beta isoform X1

    UniProtKB/TrEMBL
    F7D7A9, Q8BNE5
    Conserved Domains (1) summary
    pfam02827
    Location:41 → 109
    PKI; cAMP-dependent protein kinase inhibitor

  3. XM_006512604.5 → XP_006512667.1  cAMP-dependent protein kinase inhibitor beta isoform X2

    UniProtKB/TrEMBL
    Q5M8R3
    Conserved Domains (1) summary
    pfam02827
    Location:16 → 84
    PKI; cAMP-dependent protein kinase inhibitor

  4. XM_006512605.5 → XP_006512668.1  cAMP-dependent protein kinase inhibitor beta isoform X3

    See identical proteins and their annotated locations for XP_006512668.1

    UniProtKB/TrEMBL
    F8WGJ1, Q3TZU5, Q5M8R3
    Conserved Domains (1) summary
    pfam02827
    Location:9 → 77
    PKI; cAMP-dependent protein kinase inhibitor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04758.1 GenPept UniProtKB/Swiss-Prot:Q04758

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