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Pkdrej polycystin (PKD) family receptor for egg jelly [ Mus musculus (house mouse) ]

Gene ID: 18766, updated on 21-Apr-2024

Summary

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Official Symbol
Pkdrejprovided by MGI
Official Full Name
polycystin (PKD) family receptor for egg jellyprovided by MGI
Primary source
MGI:MGI:1338786
See related
Ensembl:ENSMUSG00000052496 AllianceGenome:MGI:1338786
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable calcium channel activity. Acts upstream of or within regulation of acrosome reaction. Located in plasma membrane. Is expressed in cochlea. Orthologous to human PKDREJ (polycystin family receptor for egg jelly). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human all
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Genomic context

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Location:
15 E2; 15 40.42 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (85698877..85705934, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (85814676..85821733, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10873 Neighboring gene peroxisome proliferator activated receptor alpha Neighboring gene STARR-seq mESC enhancer starr_39399 Neighboring gene STARR-positive B cell enhancer ABC_E5505 Neighboring gene cysteine rich, DPF motif domain containing 1 Neighboring gene tetratricopeptide repeat domain 38 Neighboring gene STARR-seq mESC enhancer starr_39401 Neighboring gene G two S phase expressed protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A polycystin-1 controls postcopulatory reproductive selection in mice. Sutton KA, et al. Proc Natl Acad Sci U S A, 2008 Jun 24. PMID 18562295, Free PMC Article
  2. Polycystic kidney disease and receptor for egg jelly is a plasma membrane protein of mouse sperm head. Butscheid Y, et al. Mol Reprod Dev, 2006 Mar. PMID 16261614
  3. Identification of a human homologue of the sea urchin receptor for egg jelly: a polycystic kidney disease-like protein. Hughes J, et al. Hum Mol Genet, 1999 Mar. PMID 9949214
  4. Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1, are co-expressed in a subset of taste receptor cells. LopezJimenez ND, et al. J Neurochem, 2006 Jul. PMID 16805797
  5. A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea. Asai Y, et al. J Assoc Res Otolaryngol, 2010 Mar. PMID 19834762, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in detection of mechanical stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of acrosome reaction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
polycystin family receptor for egg jelly
Names
PKD and REJ homolog
polycystic kidney disease (polycystin) and REJ (sperm receptor for egg jelly homolog, sea urchin)
polycystic kidney disease and receptor for egg jelly-related protein
receptor for egg jelly-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011105.2 → NP_035235.2  polycystin family receptor for egg jelly precursor

    See identical proteins and their annotated locations for NP_035235.2

    Status: VALIDATED

    Source sequence(s)
    AC117784
    Consensus CDS
    CCDS27723.1
    UniProtKB/Swiss-Prot
    Q9Z0T6
    UniProtKB/TrEMBL
    F8VQF3
    Related
    ENSMUSP00000086352.3, ENSMUST00000064370.6
    Conserved Domains (3) summary
    cd01752
    Location:1115 → 1230
    PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...
    pfam02010
    Location:130 → 598
    REJ; REJ domain
    pfam08016
    Location:1621 → 2051
    PKD_channel; Polycystin cation channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    85698877..85705934 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z0T6.1 GenPept UniProtKB/Swiss-Prot:Q9Z0T6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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