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Pja1 praja ring finger ubiquitin ligase 1 [ Mus musculus (house mouse) ]

Gene ID: 18744, updated on 3-Apr-2024

Summary

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Official Symbol
Pja1provided by MGI
Official Full Name
praja ring finger ubiquitin ligase 1provided by MGI
Primary source
MGI:MGI:1101765
See related
Ensembl:ENSMUSG00000034403 AllianceGenome:MGI:1101765
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
praja-1
Summary
Enables ubiquitin protein ligase activity. Acts upstream of or within protein catabolic process and protein ubiquitination. Located in cytoplasm. Is expressed in several structures, including central nervous system; dorsal root ganglion; ear; genitourinary system; and liver. Orthologous to human PJA1 (praja ring finger ubiquitin ligase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 68.1), CNS E14 (RPKM 57.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X C3; X 43.38 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (98509344..98514874, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (99465734..99471268, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 30798 Neighboring gene predicted gene 14808 Neighboring gene STARR-seq mESC enhancer starr_47622 Neighboring gene STARR-seq mESC enhancer starr_47623 Neighboring gene VISTA enhancer mm1347 Neighboring gene predicted gene, 31155 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:96777370-96777593 Neighboring gene predicted gene 14816

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of genes expressed in the amygdala during the formation of fear memory. Stork O, et al. Learn Mem, 2001 Jul-Aug. PMID 11533224, Free PMC Article
  2. 1-Stearoyl-2-docosahexaenoyl-phosphatidic acid interacts with and activates Praja-1, the E3 ubiquitin ligase acting on the serotonin transporter in the brain. Lu Q, et al. FEBS Lett, 2020 Jun. PMID 32134507
  3. Praja1 RING-finger E3 ubiquitin ligase suppresses neuronal cytoplasmic TDP-43 aggregate formation. Watabe K, et al. Neuropathology, 2020 Dec. PMID 32686212, Free PMC Article
  4. Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing TGFβ Signaling. Chen J, et al. Cancer Res, 2020 May 1. PMID 32127355, Free PMC Article
  5. Praja1 E3 ubiquitin ligase promotes skeletal myogenesis through degradation of EZH2 upon p38α activation. Consalvi S, et al. Nat Commun, 2017 Jan 9. PMID 28067271, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PJA1 mediates the effects of astrocytic GPR30 on learning and memory in female mice.
    Title: PJA1 mediates the effects of astrocytic GPR30 on learning and memory in female mice.
  2. Praja1 RING-finger E3 ubiquitin ligase suppresses neuronal cytoplasmic TDP-43 aggregate formation.
    Title: Praja1 RING-finger E3 ubiquitin ligase suppresses neuronal cytoplasmic TDP-43 aggregate formation.
  3. 1-Stearoyl-2-docosahexaenoyl-phosphatidic acid interacts with and activates Praja-1, the E3 ubiquitin ligase acting on the serotonin transporter in the brain.
    Title: 1-Stearoyl-2-docosahexaenoyl-phosphatidic acid interacts with and activates Praja-1, the E3 ubiquitin ligase acting on the serotonin transporter in the brain.
  4. Praja1 promotes skeletal myogenesis through degradation of EZH2 upon p38alpha activation.
    Title: Praja1 E3 ubiquitin ligase promotes skeletal myogenesis through degradation of EZH2 upon p38α activation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase Praja-1
Names
RING-type E3 ubiquitin transferase Praja-1
praja ring finger 1, E3 ubiquitin protein ligase
praja1, RING-H2 motif containing
NP_001076579.1
NP_001277484.1
NP_001277485.1
NP_001412854.1
NP_001412855.1
NP_001412856.1
NP_032879.2
XP_011245846.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083110.3 → NP_001076579.1  E3 ubiquitin-protein ligase Praja-1 isoform 1

    See identical proteins and their annotated locations for NP_001076579.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1 and 5 both encode the same isoform (1).
    Source sequence(s)
    AL831752
    Consensus CDS
    CCDS41070.1
    UniProtKB/Swiss-Prot
    O55176, Q8CFU2, Q99MJ1, Q99MJ2, Q99MJ3, Q9DB04
    UniProtKB/TrEMBL
    Q05CG5, Q3UXQ1
    Related
    ENSMUSP00000132393.2, ENSMUST00000167246.2
    Conserved Domains (1) summary
    cd16465
    Location:529 → 574
    RING-H2_PJA1_2; RING finger, H2 subclass, found in protein E3 ubiquitin-protein ligase Praja-1, Praja-2, and similar proteins

  2. NM_001290555.2 → NP_001277484.1  E3 ubiquitin-protein ligase Praja-1 isoform 3

    See identical proteins and their annotated locations for NP_001277484.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a longer N-terminus than isoform 1.
    Source sequence(s)
    AL831752
    UniProtKB/TrEMBL
    Q3UXQ1
    Related
    ENSMUSP00000109420.2, ENSMUST00000036354.7
    Conserved Domains (1) summary
    cd16465
    Location:566 → 611
    RING-H2_PJA1_2; RING finger, H2 subclass, found in protein E3 ubiquitin-protein ligase Praja-1, Praja-2, and similar proteins

  3. NM_001290556.2 → NP_001277485.1  E3 ubiquitin-protein ligase Praja-1 isoform 4

    See identical proteins and their annotated locations for NP_001277485.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame segment, compared to variant 1. The encoded isoform (4) is shorter than isoform 1. Variants 4 and 7 both encode the same isoform (4).
    Source sequence(s)
    AL831752
    Consensus CDS
    CCDS81157.1
    UniProtKB/TrEMBL
    A0JLS7, B1AXU4
    Related
    ENSMUSP00000109421.2, ENSMUST00000113790.8
    Conserved Domains (2) summary
    pfam13639
    Location:350 → 391
    zf-RING_2; Ring finger domain
    cl17018
    Location:317 → 350
    FANC; Fanconi anemia ID complex proteins FANCI and FANCD2

  4. NM_001425925.1 → NP_001412854.1  E3 ubiquitin-protein ligase Praja-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL831752
    UniProtKB/Swiss-Prot
    O55176, Q8CFU2, Q99MJ1, Q99MJ2, Q99MJ3, Q9DB04
    UniProtKB/TrEMBL
    Q05CG5

  5. NM_001425926.1 → NP_001412855.1  E3 ubiquitin-protein ligase Praja-1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL831752

  6. NM_001425927.1 → NP_001412856.1  E3 ubiquitin-protein ligase Praja-1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL831752
    UniProtKB/TrEMBL
    B1AXU4

  7. NM_008853.4 → NP_032879.2  E3 ubiquitin-protein ligase Praja-1 isoform 2

    See identical proteins and their annotated locations for NP_032879.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL831752
    Consensus CDS
    CCDS41071.1
    UniProtKB/TrEMBL
    A0JLS7, B1AXU3
    Related
    ENSMUSP00000109428.4, ENSMUST00000113797.4
    Conserved Domains (2) summary
    pfam13639
    Location:347 → 388
    zf-RING_2; Ring finger domain
    cl17018
    Location:314 → 347
    FANC; Fanconi anemia ID complex proteins FANCI and FANCD2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    98509344..98514874 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247544.1 → XP_011245846.1  E3 ubiquitin-protein ligase Praja-1 isoform X1

    See identical proteins and their annotated locations for XP_011245846.1

    UniProtKB/TrEMBL
    Q3UXQ1
    Related
    ENSMUSP00000109423.2, ENSMUST00000113792.2
    Conserved Domains (1) summary
    cd16465
    Location:566 → 611
    RING-H2_PJA1_2; RING finger, H2 subclass, found in protein E3 ubiquitin-protein ligase Praja-1, Praja-2, and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O55176.3 GenPept UniProtKB/Swiss-Prot:O55176

Gene LinkOut

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