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Pip5k1b phosphatidylinositol-4-phosphate 5-kinase, type 1 beta [ Mus musculus (house mouse) ]

Gene ID: 18719, updated on 11-Apr-2024

Summary

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Official Symbol
Pip5k1bprovided by MGI
Official Full Name
phosphatidylinositol-4-phosphate 5-kinase, type 1 betaprovided by MGI
Primary source
MGI:MGI:107930
See related
Ensembl:ENSMUSG00000024867 AllianceGenome:MGI:107930
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
STM7; Pipk5b; PIP5KIbeta; PI4P5K-I[b]; PIP5K1-beta
Summary
Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity. Acts upstream of or within phosphatidylinositol biosynthetic process. Located in cytosol. Is expressed in several structures, including brain. Orthologous to human PIP5K1B (phosphatidylinositol-4-phosphate 5-kinase type 1 beta). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: This record was renamed from Pip5k1a to Pip5k1b to conform to the annotation of human. [03 Apr 2007]
Expression
Broad expression in large intestine adult (RPKM 14.5), genital fat pad adult (RPKM 9.3) and 21 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 B; 19 19.44 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (24272158..24533236, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (24294794..24555872, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5692 Neighboring gene frataxin Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene Neighboring gene phosphatidylinositol-4-phosphate 5-kinase, type 1 beta, opposite strand Neighboring gene STARR-seq mESC enhancer starr_45802 Neighboring gene predicted gene, 52399 Neighboring gene PP2A A alpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1 Neighboring gene STARR-seq mESC enhancer starr_45804 Neighboring gene STARR-seq mESC enhancer starr_45805 Neighboring gene predicted gene, 50341 Neighboring gene STARR-seq mESC enhancer starr_45806 Neighboring gene transmembrane protein 252 Neighboring gene phosphoglucomutase 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PIP5k1β controls bone homeostasis through modulating both osteoclast and osteoblast differentiation. Zhao X, et al. J Mol Cell Biol, 2020 Jan 22. PMID 30986855, Free PMC Article
  2. Regulation of HGF-induced hepatocyte proliferation by the small GTPase Arf6 through the PIP(2)-producing enzyme PIP5K1A. Tsai MT, et al. Sci Rep, 2017 Aug 25. PMID 28842595, Free PMC Article
  3. Collaboration of AMPK and PKC to induce phosphorylation of Ser413 on PIP5K1B resulting in decreased kinase activity and reduced PtdIns(4,5)P2 synthesis in response to oxidative stress and energy restriction. van den Bout I, et al. Biochem J, 2013 Nov 1. PMID 23909401
  4. Phosphatidylinositol 5-kinase stimulates apical biosynthetic delivery via an Arp2/3-dependent mechanism. Guerriero CJ, et al. J Biol Chem, 2006 Jun 2. PMID 16601114
  5. Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}. Sasaki J, et al. J Exp Med, 2005 Mar 21. PMID 15767368, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PIP5k1beta controls bone homeostasis through modulating both osteoclast and osteoblast differentiation.
    Title: PIP5k1β controls bone homeostasis through modulating both osteoclast and osteoblast differentiation.
  2. synthesis of PtdIns(4,5)P(2) mediated by PIP5KIbeta is rate limiting for apical but not basolateral endocytosis in polarized kidney cells
    Title: PIP5KIβ selectively modulates apical endocytosis in polarized renal epithelial cells.
  3. The results suggested that PIP5K1A and PIP5K1B may coordinately and/or redundantly function in the maintenance of sperm number and morphology during spermatogenesis.
    Title: Phosphatidylinositol 4-phosphate 5-kinase is indispensable for mouse spermatogenesis.
  4. after stimulation of a G protein-coupled receptor, IP(3) is completely derived from a rapidly synthesized discrete pool of PIP(2) synthesized by PIP5KIalpha and PIP5KIbeta
    Title: Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation.
  5. PIPKIalpha activity is involved in the actin remodeling that is a prerequisite for efficient phagocytosis
    Title: Inhibition of phosphatidylinositol-4-phosphate 5-kinase Ialpha impairs localized actin remodeling and suppresses phagocytosis.
  6. These results indicate that both Arf6 and PIP5K are involved in integrin-dependent bacterial uptake, and that Arf6 participates in both activation of PIP5K as well as in other events associated with bacterial uptake.
    Title: Arf6 and phosphoinositol-4-phosphate-5-kinase activities permit bypass of the Rac1 requirement for beta1 integrin-mediated bacterial uptake.
  7. phosphatidylinositol phosphate kinase type I alpha is a negative regulator of FcepsilonRI-mediated cellular responses and anaphylaxis.
    Title: Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}.
  8. Phosphatidylinositol 4-phosphate 5-kinase is essential for ROCK-mediated neurite remodeling
    Title: Phosphatidylinositol 4-phosphate 5-kinase is essential for ROCK-mediated neurite remodeling.
  9. findings indicate that synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) by the three phosphatidylinositol 4-phosphate 5-kinase (PIP5K) isoforms Ialpha, Ibeta and Igamma is controlled by Rho GTPases
    Title: Activation of type I phosphatidylinositol 4-phosphate 5-kinase isoforms by the Rho GTPases, RhoA, Rac1, and Cdc42.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphatidylinositol biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within phosphatidylinositol metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in uropod ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phosphatidylinositol 4-phosphate 5-kinase type-1 beta
Names
68 kDa type I phosphatidylinositol 4-phosphate 5-kinase beta
PIP5KI-beta
phosphatidylinositol 4-phosphate 5-kinase type I beta
ptdIns(4)P-5-kinase 1 beta
NP_032872.1
XP_006526826.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008846.3 → NP_032872.1  phosphatidylinositol 4-phosphate 5-kinase type-1 beta

    See identical proteins and their annotated locations for NP_032872.1

    Status: VALIDATED

    Source sequence(s)
    AC150898, AI844522, AK146100
    Consensus CDS
    CCDS37940.1
    UniProtKB/Swiss-Prot
    O70335, P70181, Q8JZY6
    Related
    ENSMUSP00000025800.9, ENSMUST00000025800.15
    Conserved Domains (1) summary
    cd17307
    Location:27 → 400
    PIPKc_PIP5K1B; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase type-1 beta (PIP5K1beta) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    24272158..24533236 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526763.5 → XP_006526826.1  phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1

    See identical proteins and their annotated locations for XP_006526826.1

    UniProtKB/Swiss-Prot
    O70335, P70181, Q8JZY6
    Conserved Domains (1) summary
    cd17307
    Location:27 → 400
    PIPKc_PIP5K1B; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase type-1 beta (PIP5K1beta) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70181.1 GenPept UniProtKB/Swiss-Prot:P70181

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