Pip prolactin induced protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pipprovided by MGI
Official Full Name: prolactin induced proteinprovided by MGI
Primary source: MGI:MGI:102696
See related: Ensembl:ENSMUSG00000058499 AllianceGenome:MGI:102696
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GP17; SMGP; GCDFP-15
Summary: Predicted to enable IgG binding activity; aspartic-type endopeptidase activity; and identical protein binding activity. Acts upstream of or within regulation of immune system process. Located in apical plasma membrane and extracellular region. Is expressed in several structures, including exocrine gland and female reproductive system. Orthologous to human PIP (prolactin induced protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 6 B2.1; 6 20.05 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (41824483..41828999)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (41847549..41852065)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Generation of prolactin-inducible protein (Pip) knockout mice by CRISPR/Cas9-mediated gene engineering.
Title: Generation of prolactin-inducible protein (Pip) knockout mice by CRISPR/Cas9-mediated gene engineering.
we observed that the deficiency of Pip led to anomalies in the histology of lymphoid organs including the lymph nodes, spleen and thymus. We also observed anomalies in the morphology of the Eustachian tube and tympanic membrane in Pip deficient mice. Collectively, these data strongly suggest that Pip is an important regulator of immune responses.
Title: The prolactin inducible protein/gross cystic disease fluid protein-15 deficient mice develop anomalies in lymphoid organs.
studies show that deficiency of PIP significantly affects intracellular signaling events leading to decreased pro-inflammatory cytokine production, and further confirms a role for PIP as an important immunoregulatory protein. This direct link between PIP and cell-mediated immunity, a key component of the immune system that is critical for cancer control, may have significant therapeutic implications.
Title: The human breast cancer-associated protein, the prolactin-inducible protein (PIP), regulates intracellular signaling events and cytokine production by macrophages.
Recent work with Pip-deficient mice, linking PIP not only to a role in innate immunity but for the first time, providing evidence for a role in cell-mediated immunity. [Review]
Title: Prolactin-Inducible Protein: From Breast Cancer Biomarker to Immune Modulator-Novel Insights from Knockout Mice.
The findings implicate PIP as an important regulator of CD4(+) Th1-cell-mediated immunity.
Title: Deficiency of prolactin-inducible protein leads to impaired Th1 immune response and susceptibility to Leishmania major in mice.
these studies lend support to an immunomodulatory role for PIP in vivo and provide further insights into potentially novel signaling pathways and regulatory networks for PIP
Title: Generation and initial characterization of the prolactin-inducible protein (PIP) null mouse: accompanying global changes in gene expression in the submandibular gland.
possible function in host defense by promoting aggregation of oral bacteria
Title: Influence of mouse prolactin-inducible protein in saliva on the aggregation of oral bacteria.
examined the endogenous pattern of mouse SMGP/PIP (mSMGP/mPIP) gene expression in mid-and late-embryonic, and in early postnatal development
Title: Expression of the mouse homologue for the human GCDFP-15/PIP gene during pre- and early post-natal development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

Pip (e-PCR), detects polymorphism
- UniSTS:525622

BE630354 (e-PCR)
- UniSTS:207940

26.MMHAP59FRA11.seq (e-PCR)
- UniSTS:123745

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables IgG binding	ISO Inferred from Sequence Orthology more info
enables aspartic-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aspartic-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in regulation of immune system process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of immune system process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prolactin-inducible protein homolog

Names: 14 kDa submandibular gland protein; gross cystic disease fluid protein 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.