Pik3c2g phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pik3c2gprovided by MGI
Official Full Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gammaprovided by MGI
Primary source: MGI:MGI:1203730
See related: Ensembl:ENSMUSG00000030228 AllianceGenome:MGI:1203730
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PI3K-C2-gamma
Summary: Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Involved in chemotaxis. Predicted to be located in Golgi apparatus and nuclear envelope. Predicted to be part of phosphatidylinositol 3-kinase complex. Predicted to be active in cytoplasm and plasma membrane. Is expressed in alimentary system; central nervous system; liver; and retina. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PIK3C2G (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: suggests misassembly; Annotation category: partial on reference assembly
Expression: Biased expression in kidney adult (RPKM 1.6), liver adult (RPKM 1.3) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 G2; 6 69.7 cM

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (139591070..139915010)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (139614072..139969284)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PI3K-C2gamma-KO mice display reduced liver glycogen accumulation and develop hyperlipidemia, adiposity and insulin resistance with age or high-fat diet.
Title: PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling.
Data reveals that class II phosphoinositide 3-kinase gamma (PI3KC2gamma) expression is markedly down-regulated by p185(Bcr-Abl) but not p185(Delta176-426).
Title: Inhibition of class II phosphoinositide 3-kinase gamma expression by p185(Bcr-Abl) contributes to impaired chemotaxis and aberrant homing of leukemic cells.
Lipopolysaccharide can induce high mobility group box 1 (HMGB1) secretion by viable cardiac myocytes through a toll-like receptor 4/phosphatidylinositol 3-kinase gamma signaling pathway.
Title: The alarmin cytokine, high mobility group box 1, is produced by viable cardiomyocytes and mediates the lipopolysaccharide-induced myocardial dysfunction via a TLR4/phosphatidylinositol 3-kinase gamma pathway.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Markers

AB008791 (e-PCR)
- UniSTS:163403

Pik3c2g (e-PCR), detects polymorphism
- UniSTS:546941

RH126858 (e-PCR)
- UniSTS:208050

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-3-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-phosphatidylinositol-3-kinase activity	ISO Inferred from Sequence Orthology more info
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in modulation by host of viral process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol-3-phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
part_of phosphatidylinositol 3-kinase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: phosphatidylinositol 3-kinase C2 domain-containing subunit gamma

Names: phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma; ptdIns-3-kinase C2 subunit gamma

NP_035214.2

EC 2.7.1.137

EC 2.7.1.154

NP_997566.2

EC 2.7.1.137

EC 2.7.1.154

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011084.3 → NP_035214.2 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains multiple differences, compared to variant 1, including the lack of multiple 5' coding exons. It initiates translation at an alternate start codon. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC153381, AC159545

UniProtKB/TrEMBL

D3Z6L6

Related

ENSMUST00000189374.7

Conserved Domains (3) summary

cd06896
Location:415 → 515

PX_PI3K_C2_gamma; The phosphoinositide binding Phox Homology Domain of the Gamma Isoform of Class II Phosphoinositide 3-Kinases

cd05177
Location:33 → 386

PI3Kc_C2_gamma; Catalytic domain of Class II Phosphoinositide 3-kinase gamma

cl14603
Location:537 → 649

C2; C2 domain
NM_207683.3 → NP_997566.2 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AB008791, AC122511, AC153381, AC159545, AC174651, AK076317

UniProtKB/Swiss-Prot

O70167, O70168

Conserved Domains (5) summary

cd06896
Location:1268 → 1368

PX_PI3K_C2_gamma; The phosphoinositide binding Phox Homology Domain of the Gamma Isoform of Class II Phosphoinositide 3-Kinases

cd04012
Location:538 → 698

C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cd05177
Location:886 → 1239

PI3Kc_C2_gamma; Catalytic domain of Class II Phosphoinositide 3-kinase gamma

cl00271
Location:713 → 880

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...

cl14603
Location:1390 → 1502

C2; C2 domain