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Pick1 protein interacting with C kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 18693, updated on 25-Apr-2024

Summary

Official Symbol
Pick1provided by MGI
Official Full Name
protein interacting with C kinase 1provided by MGI
Primary source
MGI:MGI:894645
See related
Ensembl:ENSMUSG00000068206 AllianceGenome:MGI:894645
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Prkcabp
Summary
Enables protein C-terminus binding activity; protein kinase C binding activity; and signaling receptor binding activity. Involved in receptor clustering. Acts upstream of or within protein targeting. Located in several cellular components, including Golgi apparatus; perinuclear region of cytoplasm; and postsynaptic density. Is expressed in brain. Orthologous to human PICK1 (protein interacting with PRKCA 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 26.1), CNS E14 (RPKM 24.9) and 28 other tissues See more
Orthologs
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Genomic context

Location:
15 E1; 15 37.7 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79113373..79133666)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79229140..79249466)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene Sox10 multiple-species conserved sequence 8 Neighboring gene predicted gene, 52189 Neighboring gene Sox10 multiple-species conserved sequence 9 Neighboring gene STARR-seq mESC enhancer starr_39171 Neighboring gene predicted gene, 30527 Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 8 Neighboring gene lectin, galactose binding, soluble 1, pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Arp2/3 complex binding ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables SNAP receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables membrane curvature sensor activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase C binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase C binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase C binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to decreased oxygen levels ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in dendritic spine maintenance IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in dendritic spine maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in dendritic spine organization ISO
Inferred from Sequence Orthology
more info
 
involved_in glial cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
involved_in long-term synaptic depression ISO
Inferred from Sequence Orthology
more info
 
involved_in monoamine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein targeting IDA
Inferred from Direct Assay
more info
PubMed 
involved_in receptor clustering IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in receptor clustering IDA
Inferred from Direct Assay
more info
PubMed 
involved_in receptor clustering ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynaptic neurotransmitter receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synapse structure or activity NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic early endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in postsynaptic early endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic endocytic zone ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic specialization ISO
Inferred from Sequence Orthology
more info
 
located_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
is_active_in trans-Golgi network membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
PRKCA-binding protein
Names
protein kinase C-alpha-binding protein
protein that interacts with C kinase 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045558.1NP_001039023.1  PRKCA-binding protein

    See identical proteins and their annotated locations for NP_001039023.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI385692, AI893973, AK090155, BU698586
    Consensus CDS
    CCDS27635.1
    UniProtKB/TrEMBL
    E9PUZ5, Q80VC8
    Related
    ENSMUSP00000018295.8, ENSMUST00000018295.14
    Conserved Domains (2) summary
    cd07659
    Location:146360
    BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
    smart00228
    Location:1999
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
  2. NM_008837.3NP_032863.2  PRKCA-binding protein

    See identical proteins and their annotated locations for NP_032863.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI385692, AI893973, AK090155, AL591921, BU698586
    Consensus CDS
    CCDS27635.1
    UniProtKB/TrEMBL
    E9PUZ5, Q80VC8
    Related
    ENSMUSP00000128126.2, ENSMUST00000163571.8
    Conserved Domains (2) summary
    cd07659
    Location:146360
    BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
    smart00228
    Location:1999
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    79113373..79133666
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)