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Abcb4 ATP-binding cassette, sub-family B member 4 [ Mus musculus (house mouse) ]

Gene ID: 18670, updated on 16-Apr-2024

Summary

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Official Symbol
Abcb4provided by MGI
Official Full Name
ATP-binding cassette, sub-family B member 4provided by MGI
Primary source
MGI:MGI:97569
See related
Ensembl:ENSMUSG00000042476 AllianceGenome:MGI:97569
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mdr2; Pgy2; Pgy-2; mdr-2
Summary
Predicted to enable ATPase-coupled intramembrane lipid transporter activity; ATPase-coupled transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in bile acid secretion and response to fenofibrate. Located in intercellular canaliculus and plasma membrane. Is expressed in alimentary system and liver. Used to study cholecystitis; cholestasis; hepatocellular carcinoma; intrahepatic cholestasis; and primary sclerosing cholangitis. Human ortholog(s) of this gene implicated in cholestasis (multiple); gallbladder disease; and liver cirrhosis (multiple). Orthologous to human ABCB4 (ATP binding cassette subfamily B member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 22.1), liver E18 (RPKM 18.3) and 5 other tissues See more
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Genomic context

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Location:
5 A1; 5 3.43 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (8943614..9009226)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (8893614..8959226)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family B member 1A Neighboring gene predicted gene, 31157 Neighboring gene STARR-seq mESC enhancer starr_12393 Neighboring gene predicted gene 5106 Neighboring gene ATP-binding cassette, sub-family B member 1B Neighboring gene STARR-seq mESC enhancer starr_12396 Neighboring gene STARR-seq mESC enhancer starr_12398 Neighboring gene STARR-seq mESC enhancer starr_12399 Neighboring gene STARR-positive B cell enhancer ABC_E6299 Neighboring gene calponin 3, acidic pseudogene Neighboring gene predicted gene, 31388 Neighboring gene STARR-seq mESC enhancer starr_12400 Neighboring gene STARR-positive B cell enhancer mm9_chr5:8997064-8997365 Neighboring gene coiled-coil domain-containing protein 72 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12401 Neighboring gene carnitine O-octanoyltransferase Neighboring gene STARR-seq mESC enhancer starr_12402 Neighboring gene predicted gene, 40264

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gypenosides ameliorate ductular reaction and liver fibrosis via inhibition of hedgehog signaling. Hu Y, et al. Front Pharmacol, 2022. PMID 36483737, Free PMC Article
  2. The C1q-ApoE complex: A new hallmark pathology of viral hepatitis and nonalcoholic fatty liver disease. Habenicht LKL, et al. Front Immunol, 2022. PMID 36304458, Free PMC Article
  3. Prolonged Administration of Melatonin Ameliorates Liver Phenotypes in Cholestatic Murine Model. Ceci L, et al. Cell Mol Gastroenterol Hepatol, 2022. PMID 35863741, Free PMC Article
  4. Leptin Enhances Hepatic Fibrosis and Inflammation in a Mouse Model of Cholestasis. Petrescu AD, et al. Am J Pathol, 2022 Mar. PMID 34896073, Free PMC Article
  5. Administration of Human MSC-Derived Extracellular Vesicles for the Treatment of Primary Sclerosing Cholangitis: Preclinical Data in MDR2 Knockout Mice. Angioni R, et al. Int J Mol Sci, 2020 Nov 23. PMID 33238629, Free PMC Article

See all (192) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Molecular Insights of Cholestasis in MDR2 Knockout Murine Liver Organoids.
    Title: Molecular Insights of Cholestasis in MDR2 Knockout Murine Liver Organoids.
  2. Role of ABCB1 and ABCB4 in renal and biliary excretion of perfluorooctanoic acid in mice.
    Title: Role of ABCB1 and ABCB4 in renal and biliary excretion of perfluorooctanoic acid in mice.
  3. The inhibition of YAP Signaling Prevents Chronic Biliary Fibrosis in the Abcb4[-/-] Model by Modulation of Hepatic Stellate Cell and Bile Duct Epithelium Cell Pathophysiology.
    Title: The inhibition of YAP Signaling Prevents Chronic Biliary Fibrosis in the Abcb4(-/-) Model by Modulation of Hepatic Stellate Cell and Bile Duct Epithelium Cell Pathophysiology.
  4. Genetic variant c.711A>T in the hepatobiliary phospholipid transporter ABCB4 is associated with significant liver fibrosis.
    Title: Genetic variant c.711A>T in the hepatobiliary phospholipid transporter ABCB4 is associated with significant liver fibrosis.
  5. Cholangiopathy aggravation is caused by VDR ablation and alleviated by VDR-independent vitamin D signaling in ABCB4 knockout mice.
    Title: Cholangiopathy aggravation is caused by VDR ablation and alleviated by VDR-independent vitamin D signaling in ABCB4 knockout mice.
  6. The pro-oncogenic effect of the lncRNA H19 in the development of chronic inflammation-mediated hepatocellular carcinoma.
    Title: The pro-oncogenic effect of the lncRNA H19 in the development of chronic inflammation-mediated hepatocellular carcinoma.
  7. Administration of Human MSC-Derived Extracellular Vesicles for the Treatment of Primary Sclerosing Cholangitis: Preclinical Data in MDR2 Knockout Mice.
    Title: Administration of Human MSC-Derived Extracellular Vesicles for the Treatment of Primary Sclerosing Cholangitis: Preclinical Data in MDR2 Knockout Mice.
  8. Knockout of the Tachykinin Receptor 1 in the Mdr2(-/-) (Abcb4(-/-)) Mouse Model of Primary Sclerosing Cholangitis Reduces Biliary Damage and Liver Fibrosis.
    Title: Knockout of the Tachykinin Receptor 1 in the Mdr2(-/-) (Abcb4(-/-)) Mouse Model of Primary Sclerosing Cholangitis Reduces Biliary Damage and Liver Fibrosis.
  9. Cholangiocytes, but not hepatocytes, from stem cell factor (SCF) Mismatch Mdr2(-/-) mice have increased SCF expression and secretion. Inhibition of SCF in Mdr2(-/-) mice reduced (i) hepatic damage; (ii) mast cell migration; (iii) histamine and SCF serum levels.
    Title: Downregulation of hepatic stem cell factor by Vivo-Morpholino treatment inhibits mast cell migration and decreases biliary damage/senescence and liver fibrosis in Mdr2(-/-) mice.
  10. Taurohyodeoxycholate strongly enhances biliary phosphatidylcholine (PC) secretion in Abcb4+/+ mice. Taurohyodeoxycholate has no effect on biliary PC secretion in Abcb4-/- mice.
    Title: Enhancing effect of taurohyodeoxycholate on ABCB4-mediated phospholipid efflux.
Submit: New GeneRIF Correction See all GeneRIFs (31)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (7) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled intramembrane lipid transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase-coupled transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylcholine floppase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylcholine floppase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in bile acid secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to bile acid ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid translocation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cholesterol transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of phospholipid translocation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of phospholipid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in response to fenofibrate IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in xenobiotic transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular canaliculus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylcholine translocator ABCB4
Names
ATP-binding cassette, sub-family B (MDR/TAP), member 4
P glycoprotein 2
P-glycoprotein 3
multidrug resistance protein 2
multidrug resistance protein 3
NP_032856.2
XP_006503614.1
XP_006503615.1
XP_006503617.1
XP_036020767.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008830.2 → NP_032856.2  phosphatidylcholine translocator ABCB4

    See identical proteins and their annotated locations for NP_032856.2

    Status: VALIDATED

    Source sequence(s)
    AA239419, AK050345, AK144024, CB951185, CJ071650, CX204859
    Consensus CDS
    CCDS19086.1
    UniProtKB/Swiss-Prot
    B9EK77, P21440, Q6LCL9
    Related
    ENSMUSP00000003717.9, ENSMUST00000003717.13
    Conserved Domains (3) summary
    cd03249
    Location:392 → 628
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    PTZ00265
    Location:30 → 1269
    PTZ00265; multidrug resistance protein (mdr1); Provisional
    pfam00664
    Location:58 → 342
    ABC_membrane; ABC transporter transmembrane region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    8943614..9009226
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503552.2 → XP_006503615.1  phosphatidylcholine translocator ABCB4 isoform X2

    Conserved Domains (1) summary
    PTZ00265
    Location:1 → 1216
    PTZ00265; multidrug resistance protein (mdr1); Provisional

  2. XM_006503551.5 → XP_006503614.1  phosphatidylcholine translocator ABCB4 isoform X1

    Conserved Domains (2) summary
    cd03249
    Location:392 → 628
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    PTZ00265
    Location:30 → 1203
    PTZ00265; multidrug resistance protein (mdr1); Provisional

  3. XM_036164874.1 → XP_036020767.1  phosphatidylcholine translocator ABCB4 isoform X3

    Conserved Domains (1) summary
    PTZ00265
    Location:14 → 1111
    PTZ00265; multidrug resistance protein (mdr1); Provisional

  4. XM_006503554.4 → XP_006503617.1  phosphatidylcholine translocator ABCB4 isoform X4

    Conserved Domains (1) summary
    PTZ00265
    Location:37 → 1052
    PTZ00265; multidrug resistance protein (mdr1); Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21440.2 GenPept UniProtKB/Swiss-Prot:P21440

Gene LinkOut

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