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Pex16 peroxisomal biogenesis factor 16 [ Mus musculus (house mouse) ]

Gene ID: 18633, updated on 3-Apr-2024

Summary

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Official Symbol
Pex16provided by MGI
Official Full Name
peroxisomal biogenesis factor 16provided by MGI
Primary source
MGI:MGI:1338829
See related
Ensembl:ENSMUSG00000027222 AllianceGenome:MGI:1338829
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable protein C-terminus binding activity. Predicted to be involved in peroxisome organization and protein to membrane docking. Predicted to act upstream of or within protein import into peroxisome matrix. Located in peroxisomal membrane. Human ortholog(s) of this gene implicated in peroxisomal biogenesis disorder and peroxisome biogenesis disorder 8A. Orthologous to human PEX16 (peroxisomal biogenesis factor 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 68.1), subcutaneous fat pad adult (RPKM 52.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 E1; 2 50.98 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (92205043..92211563)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (92374676..92381220)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene PHD finger protein 21A Neighboring gene 60S ribosomal protein L34 pseudogene Neighboring gene STARR-seq mESC enhancer starr_05138 Neighboring gene STARR-positive B cell enhancer ABC_E1247 Neighboring gene STARR-positive B cell enhancer ABC_E4480 Neighboring gene LARGE xylosyl- and glucuronyltransferase 2 Neighboring gene mitogen-activated protein kinase 8 interacting protein 1 Neighboring gene microRNA 7000 Neighboring gene Frey regulator of sperm-oocyte fusion 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Peroxisome-derived lipids regulate adipose thermogenesis by mediating cold-induced mitochondrial fission. Park H, et al. J Clin Invest, 2019 Feb 1. PMID 30511960, Free PMC Article
  2. Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis. Fratta P, et al. EMBO J, 2018 Jun 1. PMID 29764981, Free PMC Article
  3. Peroxisome synthesis in the absence of preexisting peroxisomes. South ST, et al. J Cell Biol, 1999 Jan 25. PMID 9922452, Free PMC Article
  4. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, et al. J Biol Chem, 2004 Jan 2. PMID 14561759
  5. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in ER-dependent peroxisome localization ISO
Inferred from Sequence Orthology
more info
  
involved_in ER-dependent peroxisome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in peroxisome membrane biogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in peroxisome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peroxisome organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein import into peroxisome matrix ISO
Inferred from Sequence Orthology
more info
  
involved_in protein import into peroxisome membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to peroxisome ISO
Inferred from Sequence Orthology
more info
  
involved_in protein to membrane docking ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
peroxisomal biogenesis factor 16
Names
peroxin-16
peroxisomal membrane protein PEX16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420534.1 → NP_001407463.1  peroxisomal biogenesis factor 16 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    AL731709

  2. NM_001420535.1 → NP_001407464.1  peroxisomal biogenesis factor 16 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL731709

  3. NM_001420536.1 → NP_001407465.1  peroxisomal biogenesis factor 16 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL731709

  4. NM_145122.3 → NP_660104.2  peroxisomal biogenesis factor 16 isoform 1

    See identical proteins and their annotated locations for NP_660104.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AL731709
    Consensus CDS
    CCDS16444.1
    UniProtKB/Swiss-Prot
    Q3UPY2, Q91XC9
    UniProtKB/TrEMBL
    Q3TRJ6
    Related
    ENSMUSP00000028650.9, ENSMUST00000028650.9
    Conserved Domains (1) summary
    pfam08610
    Location:11 → 329
    Pex16; Peroxisomal membrane protein (Pex16)

RNA

  1. NR_185193.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL731709

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    92205043..92211563
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159535.1 → XP_036015428.1  peroxisomal biogenesis factor 16 isoform X1

    Conserved Domains (1) summary
    pfam08610
    Location:10 → 181
    Pex16; Peroxisomal membrane protein (Pex16)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91XC9.2 GenPept UniProtKB/Swiss-Prot:Q91XC9

Gene LinkOut

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