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Pex11b peroxisomal biogenesis factor 11 beta [ Mus musculus (house mouse) ]

Gene ID: 18632, updated on 5-Mar-2024

Summary

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Official Symbol
Pex11bprovided by MGI
Official Full Name
peroxisomal biogenesis factor 11 betaprovided by MGI
Primary source
MGI:MGI:1338882
See related
Ensembl:ENSMUSG00000028102 AllianceGenome:MGI:1338882
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PEX11beta; Pex11pbeta
Summary
Predicted to enable protein homodimerization activity. Predicted to be involved in peroxisome fission and regulation of peroxisome size. Located in mitochondrion. Used to study Zellweger syndrome. Human ortholog(s) of this gene implicated in peroxisomal biogenesis disorder. Orthologous to human PEX11B (peroxisomal biogenesis factor 11 beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 21.3), kidney adult (RPKM 12.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F2.1; 3 41.93 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (96542673..96552697)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (96635357..96645381)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6330549D23 gene Neighboring gene Lix1-like Neighboring gene STARR-positive B cell enhancer ABC_E7929 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:96439383-96439492 Neighboring gene RNA binding motif protein 8a Neighboring gene integrin, alpha 10 Neighboring gene ribosomal protein L21, pseudogene 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. High-resolution atmospheric-pressure MALDI mass spectrometry imaging workflow for lipidomic analysis of late fetal mouse lungs. Garikapati V, et al. Sci Rep, 2019 Feb 28. PMID 30816198, Free PMC Article
  2. Peroxisome elongation and constriction but not fission can occur independently of dynamin-like protein 1. Koch A, et al. J Cell Sci, 2004 Aug 1. PMID 15286177
  3. PEX11 beta deficiency is lethal and impairs neuronal migration but does not abrogate peroxisome function. Li X, et al. Mol Cell Biol, 2002 Jun. PMID 12024045, Free PMC Article
  4. Peroxisomes in airway epithelia and future prospects of these organelles for pulmonary cell biology. Karnati S, et al. Histochem Cell Biol, 2009 Apr. PMID 19229552
  5. PEX11 promotes peroxisome division independently of peroxisome metabolism. Li X, et al. J Cell Biol, 2002 Feb 18. PMID 11839773, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The alterations in the brain caused by the deletion of a single allele of the Pex11beta gene, are reported.
    Title: Deletion of a single allele of the Pex11β gene is sufficient to cause oxidative stress, delayed differentiation and neuronal death in mouse brain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: Itga10

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in peroxisome fission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peroxisome fission ISO
Inferred from Sequence Orthology
more info
  
involved_in peroxisome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of peroxisome size ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
peroxisomal membrane protein 11B
Names
PEX11-beta
peroxin-11B
peroxisomal biogenesis factor 11b
protein PEX11 homolog beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162387.1 → NP_001155859.1  peroxisomal membrane protein 11B isoform 1

    See identical proteins and their annotated locations for NP_001155859.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK082279, AK082778, BB010355, BY789006, CD806660
    Consensus CDS
    CCDS17643.1
    UniProtKB/Swiss-Prot
    Q8C4G1, Q9D090, Q9Z210
    Related
    ENSMUSP00000037962.9, ENSMUST00000048766.15
    Conserved Domains (1) summary
    pfam05648
    Location:1 → 250
    PEX11; Peroxisomal biogenesis factor 11 (PEX11)

  2. NM_001162388.1 → NP_001155860.1  peroxisomal membrane protein 11B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' and 3' UTRs, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC122037
    Consensus CDS
    CCDS51006.1
    UniProtKB/TrEMBL
    E9PXK7
    Related
    ENSMUSP00000126631.2, ENSMUST00000165842.3
    Conserved Domains (1) summary
    pfam05648
    Location:4 → 236
    PEX11; Peroxisomal biogenesis factor 11 (PEX11)

  3. NM_011069.3 → NP_035199.3  peroxisomal membrane protein 11B isoform 1

    See identical proteins and their annotated locations for NP_035199.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK011709, AK082778, BB010355, BY789006
    Consensus CDS
    CCDS17643.1
    UniProtKB/Swiss-Prot
    Q8C4G1, Q9D090, Q9Z210
    Related
    ENSMUSP00000113365.2, ENSMUST00000118557.8
    Conserved Domains (1) summary
    pfam05648
    Location:1 → 250
    PEX11; Peroxisomal biogenesis factor 11 (PEX11)

RNA

  1. NR_027844.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK005236, AK082778, BB010355, BY789006

  2. NR_027845.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate 5' exon compared to variant 1. This variant is represented as non-coding because it lacks a portion of the 5' coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AA462527, AK082778, BB010355, BQ443231, BY285331, CB525686
    Related
    ENSMUST00000144962.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    96542673..96552697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z210.1 GenPept UniProtKB/Swiss-Prot:Q9Z210

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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