Dcaf8l DDB1 and CUL4 associated factor 8 like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dcaf8lprovided by MGI
Official Full Name: DDB1 and CUL4 associated factor 8 likeprovided by MGI
Primary source: MGI:MGI:101758
See related: Ensembl:ENSMUSG00000035395 AllianceGenome:MGI:101758
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pet2; Pex3; PC231; PC326
Summary: Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human DCAF8L1 (DDB1 and CUL4 associated factor 8 like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: X C1; X 39.95 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (88447454..88453295, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (89403848..89409689, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: DDB1- and CUL4-associated factor 8-like protein 2

Names: plasmacytoma expressed transcript 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008821.2 → NP_032847.2 DDB1- and CUL4-associated factor 8-like protein 2

See identical proteins and their annotated locations for NP_032847.2

Status: VALIDATED

Source sequence(s)

AL732291

Consensus CDS

CCDS30263.1

UniProtKB/TrEMBL

A2AHY8, Q01078

Related

ENSMUSP00000109593.3, ENSMUST00000113960.3

Conserved Domains (2) summary

sd00039
Location:358 → 394

7WD40; WD40 repeat [structural motif]

cl29593
Location:345 → 666

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

88447454..88453295 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017318426.2 → XP_017173915.1 DDB1- and CUL4-associated factor 8-like protein 2 isoform X1

UniProtKB/TrEMBL

A2AHY8, Q01078

Conserved Domains (2) summary

sd00039
Location:358 → 394

7WD40; WD40 repeat [structural motif]

cl29593
Location:345 → 666

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...