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Padi2 peptidyl arginine deiminase, type II [ Mus musculus (house mouse) ]

Gene ID: 18600, updated on 21-Apr-2024

Summary

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Official Symbol
Padi2provided by MGI
Official Full Name
peptidyl arginine deiminase, type IIprovided by MGI
Primary source
MGI:MGI:1338892
See related
Ensembl:ENSMUSG00000028927 AllianceGenome:MGI:1338892
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pdi; Pdi2; mKIAA0994
Summary
Predicted to enable several functions, including estrogen receptor binding activity; protein homodimerization activity; and protein-arginine deiminase activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in transcriptionally active chromatin. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including Harderian gland; brain; early embryo; major salivary gland; and reproductive system. Orthologous to human PADI2 (peptidyl arginine deiminase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in mammary gland adult (RPKM 14.1), genital fat pad adult (RPKM 13.2) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D3; 4 73.01 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (140633685..140679897)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (140906336..140952586)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 13032 Neighboring gene peptidyl arginine deiminase, type I Neighboring gene STARR-seq mESC enhancer starr_11880 Neighboring gene RIKEN cDNA 4930515B02 gene Neighboring gene STARR-seq mESC enhancer starr_11881 Neighboring gene predicted gene, 46719 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:140486954-140487137 Neighboring gene predicted gene, 26226 Neighboring gene predicted gene, 34375 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:140500844-140501166 Neighboring gene STARR-positive B cell enhancer mm9_chr4:140501133-140501433 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:140508500-140508683 Neighboring gene STARR-seq mESC enhancer starr_11883 Neighboring gene predicted gene 13031 Neighboring gene STARR-positive B cell enhancer ABC_E10271 Neighboring gene succinate dehydrogenase complex, subunit B, iron sulfur (Ip) Neighboring gene STARR-positive B cell enhancer ABC_E6248 Neighboring gene ATPase type 13A2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inhibition of PAD2 Improves Survival in a Mouse Model of Lethal LPS-Induced Endotoxic Shock. Wu Z, et al. Inflammation, 2020 Aug. PMID 32239392, Free PMC Article
  2. Identification of PADI2 as a potential breast cancer biomarker and therapeutic target. McElwee JL, et al. BMC Cancer, 2012 Oct 30. PMID 23110523, Free PMC Article
  3. Subcellular localization of peptidylarginine deiminase 2 and citrullinated proteins in brains of scrapie-infected mice: nuclear localization of PAD2 and membrane fraction-enriched citrullinated proteins. Jang B, et al. J Neuropathol Exp Neurol, 2011 Feb. PMID 21343880
  4. Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system. Musse AA, et al. Dis Model Mech, 2008 Nov-Dec. PMID 19093029, Free PMC Article
  5. Accumulation of citrullinated proteins by up-regulated peptidylarginine deiminase 2 in brains of scrapie-infected mice: a possible role in pathogenesis. Jang B, et al. Am J Pathol, 2008 Oct. PMID 18787103, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Peptidylarginine deiminase 2 regulates expression of DGCR8 affecting miRNA biogenesis in gonadotrope cells.
    Title: Peptidylarginine deiminase 2 regulates expression of DGCR8 affecting miRNA biogenesis in gonadotrope cells.
  2. Padi2/3 Deficiency Alters the Epigenomic Landscape and Causes Premature Differentiation of Mouse Trophoblast Stem Cells.
    Title: Padi2/3 Deficiency Alters the Epigenomic Landscape and Causes Premature Differentiation of Mouse Trophoblast Stem Cells.
  3. PAD2-mediated citrullination of Fibulin-5 promotes elastogenesis.
    Title: PAD2-mediated citrullination of Fibulin-5 promotes elastogenesis.
  4. Inhibition of PAD2 Improves Survival in a Mouse Model of Lethal LPS-Induced Endotoxic Shock.
    Title: Inhibition of PAD2 Improves Survival in a Mouse Model of Lethal LPS-Induced Endotoxic Shock.
  5. Peptidylarginine deiminase 2 has potential as both a biomarker and therapeutic target of sepsis.
    Title: Peptidylarginine deiminase 2 has potential as both a biomarker and therapeutic target of sepsis.
  6. Reciprocal regulation of Th2 and Th17 cells by PAD2-mediated citrullination.
    Title: Reciprocal regulation of Th2 and Th17 cells by PAD2-mediated citrullination.
  7. Results suggest Padi2 is a novel gene involved in testis development that is specifically expressed in Sertoli cells through the regulation by SOX9 and FOXL2 and PADI2 supports regulation of target genes by SOX9.
    Title: Peptidyl arginine deiminase 2 (Padi2) is expressed in Sertoli cells in a specific manner and regulated by SOX9 during testicular development.
  8. PADi2 contributes to TNFalpha-induced citrullination and arthritis, but is not required for neutrophil extracellular traps formation
    Title: Peptidylarginine deiminase 2 is required for tumor necrosis factor alpha-induced citrullination and arthritis, but not neutrophil extracellular trap formation.
  9. Taken together, our study is the first to indicate the potential role of Padi2 as an angiogenesis-regulating gene. The characterization of Padi2 and other genes in associated pathways may provide new understanding of angiogenesis regulation and novel targets for diagnosis and treatment of a wide variety of angiogenesis-dependent diseases.
    Title: Identification of Padi2 as a novel angiogenesis-regulating gene by genome association studies in mice.
  10. peptidyl-arginine deiminases inhibiion reverses protein-hypercitrullination and disease in mouse models of multiple sclerosis.
    Title: Inhibition of peptidyl-arginine deiminases reverses protein-hypercitrullination and disease in mouse models of multiple sclerosis.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H3R26 arginine deiminase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone arginine deiminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-arginine deiminase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular estrogen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of chemokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of lymphocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation-coupled chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of euchromatin ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein-arginine deiminase type-2
Names
PAD type II
peptidyl arginine deiminase, type II; PAD type II
peptidylarginine deiminase II
protein-arginine deiminase type II
NP_001408189.1
NP_032838.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001421260.1 → NP_001408189.1  protein-arginine deiminase type-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645625, AL807805

  2. NM_008812.3 → NP_032838.2  protein-arginine deiminase type-2 isoform 1

    See identical proteins and their annotated locations for NP_032838.2

    Status: VALIDATED

    Source sequence(s)
    AL645625, AL807805
    Consensus CDS
    CCDS18857.1
    UniProtKB/Swiss-Prot
    Q08642, Q75WD0
    UniProtKB/TrEMBL
    Q3TBF1
    Related
    ENSMUSP00000030765.7, ENSMUST00000030765.7
    Conserved Domains (3) summary
    pfam03068
    Location:295 → 670
    PAD; Protein-arginine deiminase (PAD)
    pfam08526
    Location:9 → 122
    PAD_N; Protein-arginine deiminase (PAD) N-terminal domain
    pfam08527
    Location:124 → 281
    PAD_M; Protein-arginine deiminase (PAD) middle domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    140633685..140679897
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08642.2 GenPept UniProtKB/Swiss-Prot:Q08642

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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