U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Padi1 peptidyl arginine deiminase, type I [ Mus musculus (house mouse) ]

Gene ID: 18599, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Padi1provided by MGI
Official Full Name
peptidyl arginine deiminase, type Iprovided by MGI
Primary source
MGI:MGI:1338893
See related
Ensembl:ENSMUSG00000025329 AllianceGenome:MGI:1338893
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pdi1
Summary
Predicted to enable calcium ion binding activity and protein-arginine deiminase activity. Predicted to be involved in histone citrullination. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in blastocyst; early embryo; and oocyte. Orthologous to human PADI1 (peptidyl arginine deiminase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 15.4), subcutaneous fat pad adult (RPKM 3.0) and 1 other tissue See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
4 D3; 4 72.62 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (140540292..140573089, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (140812981..140845778, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:140306464-140306665 Neighboring gene peptidyl arginine deiminase, type IV Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:140338844-140339025 Neighboring gene predicted gene, 52482 Neighboring gene peptidyl arginine deiminase, type III Neighboring gene predicted gene 13032 Neighboring gene STARR-seq mESC enhancer starr_11880 Neighboring gene RIKEN cDNA 4930515B02 gene Neighboring gene STARR-seq mESC enhancer starr_11881 Neighboring gene predicted gene, 46719 Neighboring gene peptidyl arginine deiminase, type II

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type I. Guerrin M, et al. Biochem J, 2003 Feb 15. PMID 12416996, Free PMC Article
  2. Three types of mouse peptidylarginine deiminase: characterization and tissue distribution. Terakawa H, et al. J Biochem, 1991 Oct. PMID 1778991
  3. Peptidylarginine deiminase 1-catalyzed histone citrullination is essential for early embryo development. Zhang X, et al. Sci Rep, 2016 Dec 8. PMID 27929094, Free PMC Article
  4. Molecular cloning of cDNAs of mouse peptidylarginine deiminase type I, type III and type IV, and the expression pattern of type I in mouse. Rus'd AA, et al. Eur J Biochem, 1999 Feb. PMID 10092850
  5. Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6. Chavanas S, et al. Gene, 2004 Apr 14. PMID 15087120

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-arginine deiminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-arginine deiminase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-arginine deiminase activity TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein-arginine deiminase type-1
Names
PAD type I
PROTEIN-ARGININE DEIMINASE TYPE I (PEPTIDYLARGININE DEIMINASE I)
Pad type 1
peptidylarginine deiminase I
NP_035189.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011059.2 → NP_035189.1  protein-arginine deiminase type-1

    See identical proteins and their annotated locations for NP_035189.1

    Status: PROVISIONAL

    Source sequence(s)
    AL807805
    Consensus CDS
    CCDS18856.1
    UniProtKB/Swiss-Prot
    Q9Z185
    UniProtKB/TrEMBL
    Q544I4
    Related
    ENSMUSP00000026378.4, ENSMUST00000026378.4
    Conserved Domains (3) summary
    pfam03068
    Location:283 → 659
    PAD; Protein-arginine deiminase (PAD)
    pfam08526
    Location:1 → 113
    PAD_N; Protein-arginine deiminase (PAD) N-terminal domain
    pfam08527
    Location:115 → 260
    PAD_M; Protein-arginine deiminase (PAD) middle domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    140540292..140573089 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z185.1 GenPept UniProtKB/Swiss-Prot:Q9Z185

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous