Pdgfb platelet derived growth factor, B polypeptide [ Mus musculus (house mouse) ]

Gene ID: 18591, updated on 11-Apr-2024

Summary

Official Symbol: Pdgfbprovided by MGI
Official Full Name: platelet derived growth factor, B polypeptideprovided by MGI
Primary source: MGI:MGI:97528
See related: Ensembl:ENSMUSG00000000489 AllianceGenome:MGI:97528
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sis; c-sis; PDGF-2; PDGF-B
Summary: Predicted to enable several functions, including platelet-derived growth factor binding activity; protein dimerization activity; and receptor ligand activity. Involved in several processes, including metanephric glomerular mesangium development; paracrine signaling; and positive regulation of glomerular filtration. Acts upstream of or within several processes, including animal organ development; nervous system development; and regulation of cell migration. Predicted to be located in several cellular components, including basolateral plasma membrane; dendrite; and neuronal cell body. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; extraembryonic component; female reproductive system; and nervous system. Human ortholog(s) of this gene implicated in basal ganglia calcification; clear cell renal cell carcinoma; connective tissue cancer (multiple); familial meningioma; and prostatic hypertrophy. Orthologous to human PDGFB (platelet derived growth factor subunit B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 24.0), adrenal adult (RPKM 10.1) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 37.85 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (79880066..79899178, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (79995865..80024614, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An integral blood-brain barrier in adulthood relies on microglia-derived PDGFB.
Title: An integral blood-brain barrier in adulthood relies on microglia-derived PDGFB.
Breaking the feed forward inflammatory cytokine loop in the tumor microenvironment of PDGFB-driven glioblastomas.
Title: Breaking the feed forward inflammatory cytokine loop in the tumor microenvironment of PDGFB-driven glioblastomas.
Elevated PDGF-BB from Bone Impairs Hippocampal Vasculature by Inducing PDGFRbeta Shedding from Pericytes.
Title: Elevated PDGF-BB from Bone Impairs Hippocampal Vasculature by Inducing PDGFRβ Shedding from Pericytes.
Perivascular localized cells commit erythropoiesis in PDGF-B-expressing solid tumors.
Title: Perivascular localized cells commit erythropoiesis in PDGF-B-expressing solid tumors.
The Role of Platelet-Derived Growth Factor in Focal Segmental Glomerulosclerosis.
Title: The Role of Platelet-Derived Growth Factor in Focal Segmental Glomerulosclerosis.
Lin28b delays vasculature aging by reducing platelet-derived growth factor-beta resistance in senescent vascular smooth muscle cells.
Title: Lin28b delays vasculature aging by reducing platelet-derived growth factor-beta resistance in senescent vascular smooth muscle cells.
PDGF-B secreted from skeletal muscle enhances myoblast proliferation and myotube maturation via activation of the PDGFR signaling cascade.
Title: PDGF-B secreted from skeletal muscle enhances myoblast proliferation and myotube maturation via activation of the PDGFR signaling cascade.
Microglia-derived PDGFB promotes neuronal potassium currents to suppress basal sympathetic tonicity and limit hypertension.
Title: Microglia-derived PDGFB promotes neuronal potassium currents to suppress basal sympathetic tonicity and limit hypertension.
Adult-induced genetic ablation distinguishes PDGFB roles in blood-brain barrier maintenance and development.
Title: Adult-induced genetic ablation distinguishes PDGFB roles in blood-brain barrier maintenance and development.
Regulation of Transplanted Cell Homing by FGF1 and PDGFB after Doxorubicin Myocardial Injury.
Title: Regulation of Transplanted Cell Homing by FGF1 and PDGFB after Doxorubicin Myocardial Injury.

Submit: New GeneRIF Correction See all GeneRIFs (93)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

Pdgfb (e-PCR), detects polymorphism
- UniSTS:144150

Pdgfb (e-PCR), detects polymorphism
- UniSTS:144151

Pdgfb (e-PCR), detects polymorphism
- UniSTS:144152

M64849 (e-PCR)
- UniSTS:124973

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chemoattractant activity	ISO Inferred from Sequence Orthology more info
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables platelet-derived growth factor binding	ISO Inferred from Sequence Orthology more info
enables platelet-derived growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables platelet-derived growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables superoxide-generating NADPH oxidase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within actin cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in blood vessel development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within blood vessel morphogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within blood vessel morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within branching involved in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac vascular smooth muscle cell differentiation	TAS Traceable Author Statement more info	PubMed
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell projection assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mycophenolic acid	ISO Inferred from Sequence Orthology more info
involved_in cellular response to platelet-derived growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in embryonic placenta development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of endothelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within epithelial cell proliferation involved in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within eye photoreceptor cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of fibroblast growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within fibroblast migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of fibroblast migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in interleukin-18-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in metanephric glomerular endothelium development	IEP Inferred from Expression Pattern more info	PubMed
involved_in metanephric glomerular mesangial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metanephric glomerular mesangial cell proliferation involved in metanephros development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphatidylinositol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of platelet activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein binding	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular associated smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in paracrine signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in platelet-derived growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in platelet-derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in platelet-derived growth factor receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAP kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion import	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of endothelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of fibroblast growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of fibroblast migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glomerular filtration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glomerular mesangial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hepatic stellate cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hepatic stellate cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hyaluronan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of metanephric mesenchymal cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mitotic cell cycle, embryonic	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein autophosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell dedifferentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of vascular associated smooth muscle cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasoconstriction	TAS Traceable Author Statement more info	PubMed
involved_in protein kinase C signaling	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to wounding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retina vasculature development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within substrate-dependent cell migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of vascular associated smooth muscle cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of vascular associated smooth muscle cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vasoconstriction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
part_of platelet-derived growth factor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: platelet-derived growth factor subunit B

Names: PDGF subunit B; platelet-derived growth factor B chain; platelet-derived growth factor beta polypeptide; proto-oncogene c-Sis

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411619.1 → NP_001398548.1 platelet-derived growth factor subunit B isoform 2

Status: VALIDATED

Source sequence(s)

AC113595
NM_001411620.1 → NP_001398549.1 platelet-derived growth factor subunit B isoform 2

Status: VALIDATED

Source sequence(s)

AC113595

Related

ENSMUSP00000155133.2, ENSMUST00000229912.2
NM_011057.5 → NP_035187.2 platelet-derived growth factor subunit B isoform 1 preproprotein

See identical proteins and their annotated locations for NP_035187.2

Status: VALIDATED

Source sequence(s)

AC113595

Consensus CDS

CCDS27656.1

UniProtKB/Swiss-Prot

P31240, Q6P3C4

UniProtKB/TrEMBL

A0A0R4IZW4, Q549C6

Related

ENSMUSP00000000500.7, ENSMUST00000000500.8

Conserved Domains (2) summary

pfam00341
Location:97 → 180

PDGF; PDGF/VEGF domain

pfam04692
Location:21 → 93

PDGF_N; Platelet-derived growth factor, N terminal region

RNA

NR_177435.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC113595
NR_177436.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC113595
NR_177437.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC113595

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

79880066..79899178 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006520592.5 → XP_006520655.1 platelet-derived growth factor subunit B isoform X2

UniProtKB/TrEMBL

Q8R3X9

Conserved Domains (1) summary

pfam00341
Location:34 → 117

PDGF; PDGF/VEGF domain