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Pdgfb platelet derived growth factor, B polypeptide [ Mus musculus (house mouse) ]

Gene ID: 18591, updated on 9-Dec-2024

Summary

Official Symbol
Pdgfbprovided by MGI
Official Full Name
platelet derived growth factor, B polypeptideprovided by MGI
Primary source
MGI:MGI:97528
See related
Ensembl:ENSMUSG00000000489 AllianceGenome:MGI:97528
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sis; c-sis; PDGF-2; PDGF-B
Summary
Predicted to enable several functions, including platelet-derived growth factor binding activity; protein dimerization activity; and receptor ligand activity. Involved in several processes, including cellular response to platelet-derived growth factor stimulus; metanephric glomerulus vasculature development; and paracrine signaling. Acts upstream of or within several processes, including nervous system development; salivary gland morphogenesis; and vasculature development. Predicted to be located in several cellular components, including basolateral plasma membrane; cell surface; and neuronal cell body. Predicted to be part of platelet-derived growth factor complex. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; extraembryonic component; female reproductive system; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including basal ganglia calcification; clear cell renal cell carcinoma; dermatofibrosarcoma protuberans; familial meningioma; and high grade glioma (multiple). Orthologous to human PDGFB (platelet derived growth factor subunit B). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in lung adult (RPKM 24.0), adrenal adult (RPKM 10.1) and 20 other tissues See more
Orthologs
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Genomic context

See Pdgfb in Genome Data Viewer
Location:
15 E1; 15 37.85 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79880066..79899178, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79995865..80024614, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3 Neighboring gene STARR-seq mESC enhancer starr_39204 Neighboring gene STARR-positive B cell enhancer ABC_E7392 Neighboring gene chromobox 7 Neighboring gene STARR-positive B cell enhancer mm9_chr15:79765174-79765475 Neighboring gene STARR-positive B cell enhancer ABC_E9420 Neighboring gene VISTA enhancer mm570 Neighboring gene STARR-seq mESC enhancer starr_39213 Neighboring gene predicted gene, 53903 Neighboring gene microRNA 7213 Neighboring gene predicted gene, 41361 Neighboring gene predicted gene, 53904 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:79880582-79880810 Neighboring gene predicted gene, 41362

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chemoattractant activity  
enables collagen binding  
enables growth factor activity  
enables growth factor activity  
enables identical protein binding  
enables platelet-derived growth factor binding  
enables platelet-derived growth factor receptor binding  
enables platelet-derived growth factor receptor binding  
enables platelet-derived growth factor receptor binding  
enables protein heterodimerization activity  
enables protein homodimerization activity  
enables protein homodimerization activity  
enables signaling receptor binding  
enables superoxide-generating NADPH oxidase activator activity  
enables superoxide-generating NADPH oxidase activator activity  
Items 1 - 25 of 134
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization PubMed 
acts_upstream_of_or_within actin cytoskeleton organization PubMed 
involved_in angiogenesis  
involved_in blood vessel development PubMed 
acts_upstream_of_or_within blood vessel morphogenesis PubMed 
acts_upstream_of_or_within blood vessel morphogenesis PubMed 
acts_upstream_of_or_within branching involved in salivary gland morphogenesis PubMed 
involved_in cardiac vascular smooth muscle cell differentiation PubMed 
involved_in cell chemotaxis  
involved_in cell chemotaxis  
acts_upstream_of cell migration PubMed 
acts_upstream_of_or_within cell projection assembly PubMed 
involved_in cellular response to growth factor stimulus  
involved_in cellular response to mycophenolic acid  
involved_in cellular response to mycophenolic acid  
involved_in cellular response to platelet-derived growth factor stimulus PubMed 
involved_in embryonic placenta development PubMed 
acts_upstream_of endothelial cell proliferation PubMed 
acts_upstream_of_or_within epithelial cell proliferation involved in salivary gland morphogenesis PubMed 
acts_upstream_of_or_within eye photoreceptor cell development PubMed 
acts_upstream_of fibroblast growth factor receptor signaling pathway PubMed 
acts_upstream_of_or_within fibroblast migration PubMed 
acts_upstream_of fibroblast migration PubMed 
involved_in gene expression  
acts_upstream_of_or_within glial cell development PubMed 
involved_in heart development PubMed 
NOT involved_in hemopoiesis  
involved_in interleukin-18-mediated signaling pathway  
involved_in metanephric glomerular endothelium development PubMed 
involved_in metanephric glomerular mesangial cell development PubMed 
involved_in metanephric glomerular mesangial cell proliferation involved in metanephros development PubMed 
involved_in monocyte chemotaxis  
involved_in monocyte chemotaxis  
involved_in negative regulation of DNA-templated transcription  
involved_in negative regulation of gene expression  
involved_in negative regulation of gene expression  
involved_in negative regulation of miRNA transcription  
involved_in negative regulation of phosphatidylinositol biosynthetic process  
involved_in negative regulation of phosphatidylinositol biosynthetic process  
involved_in negative regulation of platelet activation  
involved_in negative regulation of platelet activation  
involved_in negative regulation of protein binding  
involved_in negative regulation of vascular associated smooth muscle cell differentiation  
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell migration PubMed 
acts_upstream_of_or_within neuron remodeling PubMed 
involved_in paracrine signaling PubMed 
involved_in peptidyl-tyrosine phosphorylation  
involved_in peptidyl-tyrosine phosphorylation  
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
involved_in platelet-derived growth factor receptor signaling pathway  
involved_in platelet-derived growth factor receptor signaling pathway  
involved_in platelet-derived growth factor receptor signaling pathway  
involved_in platelet-derived growth factor receptor signaling pathway PubMed 
involved_in positive regulation of DNA biosynthetic process  
involved_in positive regulation of DNA biosynthetic process  
involved_in positive regulation of DNA replication  
involved_in positive regulation of DNA-templated transcription  
involved_in positive regulation of DNA-templated transcription  
involved_in positive regulation of ERK1 and ERK2 cascade  
involved_in positive regulation of ERK1 and ERK2 cascade  
involved_in positive regulation of ERK1 and ERK2 cascade  
involved_in positive regulation of MAP kinase activity  
involved_in positive regulation of MAP kinase activity  
involved_in positive regulation of MAPK cascade  
involved_in positive regulation of MAPK cascade  
involved_in positive regulation of blood vessel endothelial cell migration  
involved_in positive regulation of blood vessel endothelial cell migration  
involved_in positive regulation of calcium ion import  
involved_in positive regulation of calcium ion import  
involved_in positive regulation of cell division  
involved_in positive regulation of cell migration  
involved_in positive regulation of cell migration  
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of cell-substrate adhesion  
involved_in positive regulation of chemotaxis  
involved_in positive regulation of chemotaxis  
involved_in positive regulation of collagen biosynthetic process  
acts_upstream_of_or_within positive regulation of endothelial cell proliferation PubMed 
involved_in positive regulation of endothelial cell proliferation  
acts_upstream_of_or_within positive regulation of fibroblast growth factor receptor signaling pathway PubMed 
acts_upstream_of_or_within positive regulation of fibroblast migration PubMed 
involved_in positive regulation of fibroblast proliferation  
involved_in positive regulation of fibroblast proliferation  
involved_in positive regulation of gene expression PubMed 
involved_in positive regulation of gene expression  
involved_in positive regulation of glomerular filtration PubMed 
involved_in positive regulation of glomerular mesangial cell proliferation  
involved_in positive regulation of glomerular mesangial cell proliferation  
involved_in positive regulation of hepatic stellate cell activation  
involved_in positive regulation of hepatic stellate cell proliferation  
involved_in positive regulation of hyaluronan biosynthetic process  
involved_in positive regulation of hyaluronan biosynthetic process  
involved_in positive regulation of metanephric mesenchymal cell migration  
involved_in positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway  
involved_in positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway  
involved_in positive regulation of miRNA transcription  
acts_upstream_of_or_within positive regulation of mitotic cell cycle, embryonic PubMed 
involved_in positive regulation of mitotic nuclear division  
involved_in positive regulation of mitotic nuclear division  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
involved_in positive regulation of protein autophosphorylation  
involved_in positive regulation of protein autophosphorylation  
involved_in positive regulation of reactive oxygen species metabolic process  
involved_in positive regulation of reactive oxygen species metabolic process  
involved_in positive regulation of smooth muscle cell migration PubMed 
involved_in positive regulation of smooth muscle cell migration  
involved_in positive regulation of smooth muscle cell proliferation PubMed 
involved_in positive regulation of smooth muscle cell proliferation PubMed 
involved_in positive regulation of smooth muscle cell proliferation  
involved_in positive regulation of vascular associated smooth muscle cell dedifferentiation  
involved_in positive regulation of vascular associated smooth muscle cell migration  
acts_upstream_of_or_within positive regulation of vascular associated smooth muscle cell proliferation PubMed 
involved_in positive regulation of vascular associated smooth muscle cell proliferation  
involved_in positive regulation of vasoconstriction PubMed 
involved_in protein kinase C signaling  
involved_in protein phosphorylation  
involved_in protein phosphorylation  
involved_in reactive oxygen species metabolic process  
involved_in reactive oxygen species metabolic process  
acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation PubMed 
involved_in response to wounding  
involved_in response to wounding  
acts_upstream_of_or_within retina development in camera-type eye PubMed 
acts_upstream_of_or_within retina vasculature development in camera-type eye PubMed 
acts_upstream_of_or_within substrate-dependent cell migration PubMed 
acts_upstream_of_or_within synapse assembly PubMed 
acts_upstream_of vascular associated smooth muscle cell migration PubMed 
acts_upstream_of vascular associated smooth muscle cell proliferation PubMed 
involved_in vasoconstriction PubMed 
Items 1 - 25 of 134
Component Evidence Code Pubs
located_in basolateral plasma membrane  
located_in basolateral plasma membrane  
located_in cell surface  
located_in cell surface  
located_in cytoplasm  
located_in cytoplasm  
located_in dendrite  
located_in extracellular region  
is_active_in extracellular space  
located_in extracellular space  
located_in neuronal cell body  
part_of platelet-derived growth factor complex  

General protein information

Preferred Names
platelet-derived growth factor subunit B
Names
PDGF subunit B
platelet-derived growth factor B chain
platelet-derived growth factor beta polypeptide
proto-oncogene c-Sis

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411619.1NP_001398548.1  platelet-derived growth factor subunit B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113595
    UniProtKB/TrEMBL
    Q8R3X9
  2. NM_001411620.1NP_001398549.1  platelet-derived growth factor subunit B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113595
    UniProtKB/TrEMBL
    Q8R3X9
    Related
    ENSMUSP00000155133.2, ENSMUST00000229912.2
  3. NM_011057.5NP_035187.2  platelet-derived growth factor subunit B isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_035187.2

    Status: VALIDATED

    Source sequence(s)
    AC113595
    Consensus CDS
    CCDS27656.1
    UniProtKB/Swiss-Prot
    P31240, Q6P3C4
    UniProtKB/TrEMBL
    A0A0R4IZW4, Q549C6
    Related
    ENSMUSP00000000500.7, ENSMUST00000000500.8
    Conserved Domains (2) summary
    pfam00341
    Location:97180
    PDGF; PDGF/VEGF domain
    pfam04692
    Location:2193
    PDGF_N; Platelet-derived growth factor, N terminal region

RNA

  1. NR_177435.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113595
  2. NR_177436.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113595
  3. NR_177437.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113595

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    79880066..79899178 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520592.5XP_006520655.1  platelet-derived growth factor subunit B isoform X2

    UniProtKB/TrEMBL
    Q8R3X9
    Conserved Domains (1) summary
    pfam00341
    Location:34117
    PDGF; PDGF/VEGF domain
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