Pdgfa platelet derived growth factor, alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pdgfaprovided by MGI
Official Full Name: platelet derived growth factor, alphaprovided by MGI
Primary source: MGI:MGI:97527
See related: Ensembl:ENSMUSG00000025856 AllianceGenome:MGI:97527
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PDGF-1
Summary: Predicted to enable several functions, including platelet-derived growth factor binding activity; protein dimerization activity; and signaling receptor binding activity. Involved in digestive tract development and embryonic lung development. Acts upstream of or within several processes, including animal organ development; positive regulation of mesenchymal cell proliferation; and regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling. Located in extracellular space and microvillus. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human PDGFA (platelet derived growth factor subunit A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 22.6), colon adult (RPKM 19.0) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 77.65 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (138961761..138986336, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (138976014..139000792, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic analyses in mouse fibroblast and melanoma cells demonstrate novel roles for PDGF-AB ligand and PDGF receptor alpha.
Title: Genetic analyses in mouse fibroblast and melanoma cells demonstrate novel roles for PDGF-AB ligand and PDGF receptor alpha.
CPEB2-activated PDGFRalpha mRNA translation contributes to myofibroblast proliferation and pulmonary alveologenesis.
Title: CPEB2-activated PDGFRα mRNA translation contributes to myofibroblast proliferation and pulmonary alveologenesis.
The authors' observations demonstrate the previously unappreciated postnatal role of PDGFA/PDGFRalpha in controlling elastogenic gene expression via a secondary tier of signaling networks composed of EGF and TGFbeta.
Title: Secondary crest myofibroblast PDGFRα controls the elastogenesis pathway via a secondary tier of signaling networks during alveologenesis.
PDGF signaling in primitive endoderm cell survival is mediated by PI3K-mTOR through p53-independent mechanism.
Title: PDGF Signaling in Primitive Endoderm Cell Survival Is Mediated by PI3K-mTOR Through p53-Independent Mechanism.
Strenuous running suppresses the synthesis of PDGF-AA in subchondral bone, leading to downregulated PDGF/Akt signal in articular cartilage and thus cartilage degeneration.
Title: Reduced PDGF-AA in subchondral bone leads to articular cartilage degeneration after strenuous running.
In summary, the authors concluded that glycosylation-dependent Gal-1/NRP-1 interactions activate TGF-beta and PDGF-like signaling to promote the migration and activation of hepatic stellate cells.
Title: Glycosylation-dependent galectin-1/neuropilin-1 interactions promote liver fibrosis through activation of TGF-β- and PDGF-like signals in hepatic stellate cells.
FSP1-expressiing fibroblasts maintain preadipocyte pool via PDGF signaling and regulate adipose homeostasis.
Title: FSP1-positive fibroblasts are adipogenic niche and regulate adipose homeostasis.
PDGF-A signaling is involved in myofibroblast proliferation and migration.
Title: PDGF-A signaling is required for secondary alveolar septation and controls epithelial proliferation in the developing lung.
These studies uncover PI3K/AKT2 as a direct PDGFA target that is activated in adipocyte stem cells.
Title: Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis.
stronger fibrotic effect generated by Platelet-derived growth factor alpha overexpression was mediated by Platelet-derived growth factor receptor alphalpha in cardiac interstitial mesenchymal cells
Title: PDGF-A and PDGF-B induces cardiac fibrosis in transgenic mice.

Submit: New GeneRIF Correction See all GeneRIFs (46)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

Pdgfa (e-PCR), detects polymorphism
- UniSTS:144149

Pdgfa (e-PCR), detects polymorphism
- UniSTS:464685

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables platelet-derived growth factor binding	ISO Inferred from Sequence Orthology more info
enables platelet-derived growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables platelet-derived growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within angiogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within animal organ morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within animal organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bone development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell projection assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within digestive tract development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in digestive tract development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic lung development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hair follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung alveolus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lung alveolus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphatidylinositol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of platelet activation	ISO Inferred from Sequence Orthology more info
involved_in platelet-derived growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in platelet-derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in platelet-derived growth factor receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in platelet-derived growth factor receptor-alpha signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAP kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein autophosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein autophosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in response to wounding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skin development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed
part_of platelet-derived growth factor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: platelet-derived growth factor subunit A

Names: PDGF A-chain; PDGF subunit A; platelet-derived growth factor A-chain; platelet-derived growth factor alpha polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001363271.1 → NP_001350200.1 platelet-derived growth factor subunit A isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC117698

Consensus CDS

CCDS90003.1

UniProtKB/Swiss-Prot

P20033

UniProtKB/TrEMBL

G5E891, Q7TPH7

Related

ENSMUSP00000038870.7, ENSMUST00000046901.14

Conserved Domains (2) summary

smart00141
Location:94 → 181

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

pfam04692
Location:21 → 95

PDGF_N; Platelet-derived growth factor, N terminal region
NM_001422136.1 → NP_001409065.1 platelet-derived growth factor subunit A isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC117698

UniProtKB/Swiss-Prot

P20033

UniProtKB/TrEMBL

G5E891
NM_001422139.1 → NP_001409068.1 platelet-derived growth factor subunit A isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC117698

UniProtKB/TrEMBL

Q99L56
NM_001422140.1 → NP_001409069.1 platelet-derived growth factor subunit A isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC117698

UniProtKB/TrEMBL

Q99L56
NM_008808.4 → NP_032834.1 platelet-derived growth factor subunit A isoform 1 precursor

See identical proteins and their annotated locations for NP_032834.1

Status: VALIDATED

Source sequence(s)

AC117698

Consensus CDS

CCDS19802.1

UniProtKB/TrEMBL

Q7TPH7, Q99L56

Related

ENSMUSP00000075463.8, ENSMUST00000076095.14

Conserved Domains (2) summary

smart00141
Location:94 → 181

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

pfam04692
Location:21 → 95

PDGF_N; Platelet-derived growth factor, N terminal region

RNA

NR_156469.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' exon and lacks the open reading frame found in variant 1.

Source sequence(s)

AC117698

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

138961761..138986336 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011240971.4 → XP_011239273.1 platelet-derived growth factor subunit A isoform X1

See identical proteins and their annotated locations for XP_011239273.1

UniProtKB/Swiss-Prot

P20033

UniProtKB/TrEMBL

G5E891, Q7TPH7

Conserved Domains (2) summary

smart00141
Location:94 → 181

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

pfam04692
Location:21 → 95

PDGF_N; Platelet-derived growth factor, N terminal region
XM_036164870.1 → XP_036020763.1 platelet-derived growth factor subunit A isoform X1

UniProtKB/Swiss-Prot

P20033

UniProtKB/TrEMBL

G5E891, Q7TPH7

Conserved Domains (2) summary

smart00141
Location:94 → 181

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

pfam04692
Location:21 → 95

PDGF_N; Platelet-derived growth factor, N terminal region