U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pde6g phosphodiesterase 6G, cGMP-specific, rod, gamma [ Mus musculus (house mouse) ]

Gene ID: 18588, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Pde6gprovided by MGI
Official Full Name
phosphodiesterase 6G, cGMP-specific, rod, gammaprovided by MGI
Primary source
MGI:MGI:97526
See related
Ensembl:ENSMUSG00000025386 AllianceGenome:MGI:97526
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pdeg; p3AT
Summary
Predicted to enable spectrin binding activity. Acts upstream of or within positive regulation of G protein-coupled receptor signaling pathway; positive regulation of MAPK cascade; and positive regulation of epidermal growth factor receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be active in photoreceptor outer segment membrane. Is expressed in retina outer nuclear layer. Used to study retinitis pigmentosa. Human ortholog(s) of this gene implicated in retinitis pigmentosa 57. Orthologous to human PDE6G (phosphodiesterase 6G). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
11 E2; 11 84.14 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120338433..120344326, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120447607..120453500, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene NPL4 homolog, ubiquitin recognition factor Neighboring gene STARR-seq mESC enhancer starr_31358 Neighboring gene STARR-seq mESC enhancer starr_31359 Neighboring gene tetraspanin 10 Neighboring gene coiled-coil domain containing 137 Neighboring gene oxidoreductase like domain containing 1 Neighboring gene ADP-ribosylation factor-like 16

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Effect of the ILE86TER mutation in the γ subunit of cGMP phosphodiesterase (PDE6) on rod photoreceptor signaling. Tsang SH, et al. Cell Signal, 2012 Jan. PMID 21920434, Free PMC Article
  2. Function of the asparagine 74 residue of the inhibitory γ-subunit of retinal rod cGMP-phophodiesterase (PDE) in vivo. Tsang SH, et al. Cell Signal, 2011 Oct. PMID 21616145, Free PMC Article
  3. Removal of phosphorylation sites of gamma subunit of phosphodiesterase 6 alters rod light response. Tsang SH, et al. J Physiol, 2007 Mar 1. PMID 17138607, Free PMC Article
  4. The positive role of the carboxyl terminus of the gamma subunit of retinal cGMP-phosphodiesterase in maintaining phosphodiesterase activity in vivo. Tsang SH, et al. Vision Res, 2002 Feb. PMID 11853759
  5. In vivo studies of the gamma subunit of retinal cGMP-phophodiesterase with a substitution of tyrosine-84. Tsang SH, et al. Biochem J, 2001 Feb 1. PMID 11171042, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study sheds new light on the versatility of tetratricopeptide repeat domain (TPR) domains in protein folding by describing a novel TPR-protein binding partner, Pgamma, and revealing that this subunit imparts AIPL1 selectivity for its client.
    Title: Interaction of the tetratricopeptide repeat domain of aryl hydrocarbon receptor-interacting protein-like 1 with the regulatory Pγ subunit of phosphodiesterase 6.
  2. AIPL1-mediated production of folded PDE6C is markedly elevated in the presence of the inhibitory Pgamma-subunit of PDE6.
    Title: Aryl Hydrocarbon Receptor-interacting Protein-like 1 Is an Obligate Chaperone of Phosphodiesterase 6 and Is Assisted by the γ-Subunit of Its Client.
  3. The presence of rod PDE6G in cones indicating functional substitution of PDE6h in mice.
    Title: Targeted ablation of the Pde6h gene in mice reveals cross-species differences in cone and rod phototransduction protein isoform inventory.
  4. our results show for the first time that the Ile(86) and Ile(87) residues of PDE6-gamma are necessary for normal inhibition of PDE6 catalytic activity in vivo
    Title: Effect of the ILE86TER mutation in the γ subunit of cGMP phosphodiesterase (PDE6) on rod photoreceptor signaling.
  5. PDE6gamma is a major component of the photoresponse and is required to support rod integrity.
    Title: Function of the asparagine 74 residue of the inhibitory γ-subunit of retinal rod cGMP-phophodiesterase (PDE) in vivo.
  6. Results suggest that the polycationic domain of PDE6 gamma containing these two phosphorylation sites can influence the rate of PDE6 activation and could modify the time course of transduction, thereby influencing the wave form of the light response.
    Title: Removal of phosphorylation sites of gamma subunit of phosphodiesterase 6 alters rod light response.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3',5'-cyclic-GMP phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables cGMP binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables spectrin binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of epidermal growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to stimulus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within visual perception IEA
Inferred from Electronic Annotation
more info
  
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in photoreceptor outer segment membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

Go to the top of the page Help
Preferred Names
retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Names
GMP-PDE gamma
cGMP phosphodiesterase gamma
NP_036197.1
XP_006532518.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012065.3 → NP_036197.1  retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

    See identical proteins and their annotated locations for NP_036197.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AK080735, AL669855
    Consensus CDS
    CCDS36389.1
    UniProtKB/Swiss-Prot
    P09174
    UniProtKB/TrEMBL
    Q542R6
    Related
    ENSMUSP00000026452.3, ENSMUST00000026452.3
    Conserved Domains (1) summary
    pfam04868
    Location:6 → 87
    PDE6_gamma; Retinal cGMP phosphodiesterase, gamma subunit

RNA

  1. NR_126089.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' region compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AK080735, AL669855, CK619967
    Related
    ENSMUST00000141795.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    120338433..120344326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532455.3 → XP_006532518.1  retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma isoform X1

    See identical proteins and their annotated locations for XP_006532518.1

    UniProtKB/Swiss-Prot
    P09174
    UniProtKB/TrEMBL
    Q542R6
    Conserved Domains (1) summary
    pfam04868
    Location:6 → 87
    PDE6_gamma; Retinal cGMP phosphodiesterase, gamma subunit
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P09174.1 GenPept UniProtKB/Swiss-Prot:P09174

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous