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Pde4b phosphodiesterase 4B, cAMP specific [ Mus musculus (house mouse) ]

Gene ID: 18578, updated on 21-Apr-2024

Summary

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Official Symbol
Pde4bprovided by MGI
Official Full Name
phosphodiesterase 4B, cAMP specificprovided by MGI
Primary source
MGI:MGI:99557
See related
Ensembl:ENSMUSG00000028525 AllianceGenome:MGI:99557
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dpde4; dunce
Summary
Enables 3',5'-cyclic-AMP phosphodiesterase activity; gamma-tubulin binding activity; and transmembrane transporter binding activity. Involved in several processes, including cellular response to epinephrine stimulus; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process; and regulation of muscle system process. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; neutrophil chemotaxis; and neutrophil homeostasis. Located in several cellular components, including Z disc; centrosome; and synaptic vesicle. Part of gamma-tubulin complex and voltage-gated calcium channel complex. Is expressed in several structures, including alimentary system; ear; genitourinary system; nervous system; and respiratory system. Orthologous to human PDE4B (phosphodiesterase 4B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 9.7), frontal lobe adult (RPKM 9.3) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 C6; 4 46.99 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (101944529..102464459)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (102087332..102607275)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10922 Neighboring gene STARR-seq mESC enhancer starr_10923 Neighboring gene PRAME like 62 Neighboring gene STARR-seq mESC enhancer starr_10924 Neighboring gene RNA binding motif protein 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_10925 Neighboring gene predicted gene, 52669 Neighboring gene zinc finger protein 352 pseudogene Neighboring gene zinc finger protein 352 pseudogene Neighboring gene STARR-seq mESC enhancer starr_10926 Neighboring gene STARR-positive B cell enhancer ABC_E3498 Neighboring gene STARR-positive B cell enhancer mm9_chr4:102178342-102178642 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:102184116-102184299 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:102184409-102184518 Neighboring gene STARR-positive B cell enhancer ABC_E4639 Neighboring gene STARR-positive B cell enhancer ABC_E1034 Neighboring gene predicted gene, 52668 Neighboring gene STARR-seq mESC enhancer starr_10927 Neighboring gene predicted gene, 52667 Neighboring gene predicted gene, 24869 Neighboring gene STARR-seq mESC enhancer starr_10929 Neighboring gene SH3-domain GRB2-like (endophilin) interacting protein 1 Neighboring gene predicted gene 12709

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Declines in PDE4B activity promote myopia progression through downregulation of scleral collagen expression. Zhao F, et al. Exp Eye Res, 2021 Nov. PMID 34506801
  2. Ablation of PDE4B protects from Pseudomonas aeruginosa-induced acute lung injury in mice by ameliorating the cytostorm and associated hypothermia. Abou Saleh L, et al. FASEB J, 2021 Sep. PMID 34383981, Free PMC Article
  3. Selective Inhibition of PDE4B Reduces Binge Drinking in Two C57BL/6 Substrains. Jimenez Chavez CL, et al. Int J Mol Sci, 2021 May 21. PMID 34064099, Free PMC Article
  4. Following spinal cord injury, PDE4B drives an acute, local inflammatory response and a chronic, systemic response exacerbated by gut dysbiosis and endotoxemia. Myers SA, et al. Neurobiol Dis, 2019 Apr. PMID 30557659, Free PMC Article
  5. Altered phosphorylation, electrophysiology, and behavior on attenuation of PDE4B action in hippocampus. Campbell SL, et al. BMC Neurosci, 2017 Dec 2. PMID 29197324, Free PMC Article

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA GAS5 Knockdown Mitigates Hepatic Lipid Accumulation via Regulating MiR-26a-5p/PDE4B to Activate cAMP/CREB Pathway.
    Title: LncRNA GAS5 Knockdown Mitigates Hepatic Lipid Accumulation via Regulating MiR-26a-5p/PDE4B to Activate cAMP/CREB Pathway.
  2. Declines in PDE4B activity promote myopia progression through downregulation of scleral collagen expression.
    Title: Declines in PDE4B activity promote myopia progression through downregulation of scleral collagen expression.
  3. Phosphodiesterase 4B is required for NLRP3 inflammasome activation by positive feedback with Nrf2 in the early phase of LPS- induced acute lung injury.
    Title: Phosphodiesterase 4B is required for NLRP3 inflammasome activation by positive feedback with Nrf2 in the early phase of LPS- induced acute lung injury.
  4. Evidence for reprogramming of monocytes into reparative alveolar macrophages in vivo by targeting PDE4b.
    Title: Evidence for reprogramming of monocytes into reparative alveolar macrophages in vivo by targeting PDE4b.
  5. circPDE4B prevents articular cartilage degeneration and promotes repair by acting as a scaffold for RIC8A and MID1.
    Title: circPDE4B prevents articular cartilage degeneration and promotes repair by acting as a scaffold for RIC8A and MID1.
  6. Ablation of PDE4B protects from Pseudomonas aeruginosa-induced acute lung injury in mice by ameliorating the cytostorm and associated hypothermia.
    Title: Ablation of PDE4B protects from Pseudomonas aeruginosa-induced acute lung injury in mice by ameliorating the cytostorm and associated hypothermia.
  7. Selective Inhibition of PDE4B Reduces Binge Drinking in Two C57BL/6 Substrains.
    Title: Selective Inhibition of PDE4B Reduces Binge Drinking in Two C57BL/6 Substrains.
  8. these findings indicate that PDE4B plays an important role in the development of acute and chronic inflammatory response and consequent recovery following spinal cord injury
    Title: Following spinal cord injury, PDE4B drives an acute, local inflammatory response and a chronic, systemic response exacerbated by gut dysbiosis and endotoxemia.
  9. In vivo, the atropine-dependent prolongation of heart rate increase was blunted in PDE4D but not in wildtype or PDE4B knockout mice. The authors propose that inhibition of PDE4 by atropine accounts, at least in part, for the induction of tachycardia and the arrhythmogenic potency of this drug.
    Title: Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4.
  10. Study combined mutational analysis in the Apc mutated mice with published studies of frank colon cancer in patients to deduce that Pde4b has two strong biological functions. It negatively regulates colonic adenomagenesis in Apc mutated mice. In patients, PDE4B is most commonly inactivated by an epigenetic process.
    Title: The conserved protective cyclic AMP-phosphodiesterase function PDE4B is expressed in the adenoma and adjacent normal colonic epithelium of mammals and silenced in colorectal cancer.
Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cAMP binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium channel regulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables gamma-tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to epinephrine stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cellular response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within leukocyte migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of relaxation of cardiac muscle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neutrophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neutrophil homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cardiac muscle cell contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT acts_upstream_of_or_within smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cell periphery IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
 PubMed 
located_in excitatory synapse IDA
Inferred from Direct Assay
more info
 PubMed 
part_of gamma-tubulin complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
part_of voltage-gated calcium channel complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
3',5'-cyclic-AMP phosphodiesterase 4B
NP_001171451.1
NP_001171452.1
NP_001171453.1
NP_001171454.1
NP_001361709.1
NP_001391715.1
NP_001391716.1
NP_001391717.1
NP_001391718.1
NP_001391720.1
NP_001391722.1
NP_001391723.1
NP_001391725.1
NP_001391733.1
NP_001391765.1
NP_062814.2
XP_006502919.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177980.2 → NP_001171451.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several 5' exons but has an alternate 5' segment, as compared to variant 1. The resulting isoform (2) is shorter and has a different N-terminus, as compared to isoform 1.
    Source sequence(s)
    AL732551, AL772358
    Consensus CDS
    CCDS51243.1
    UniProtKB/TrEMBL
    B1AWD0, Q91VY2
    Related
    ENSMUSP00000095562.3, ENSMUST00000097950.9
    Conserved Domains (1) summary
    pfam00233
    Location:233 → 474
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  2. NM_001177981.1 → NP_001171452.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 3

    See identical proteins and their annotated locations for NP_001171452.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several 5' exons but has an alternate 5' exon, as compared to variant 1. The resulting isoform (3) is shorter and has a different N-terminus, as compared to isoform 1.
    Source sequence(s)
    AL732551, BB654856, BC071259
    Consensus CDS
    CCDS51244.1
    UniProtKB/TrEMBL
    Q6IQY6, Q91VY2
    Related
    ENSMUSP00000095561.5, ENSMUST00000097949.11
    Conserved Domains (1) summary
    pfam00233
    Location:172 → 413
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  3. NM_001177982.1 → NP_001171453.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 4

    See identical proteins and their annotated locations for NP_001171453.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks several 5' exons but has an alternate 5' exon, as compared to variant 1. The resulting isoform (4) has a much shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK161341, AL732551
    Consensus CDS
    CCDS51245.1
    UniProtKB/TrEMBL
    Q3TTI9, Q91VY2
    Related
    ENSMUSP00000030251.7, ENSMUST00000030251.13
    Conserved Domains (1) summary
    pfam00233
    Location:153 → 394
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  4. NM_001177983.2 → NP_001171454.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 5

    See identical proteins and their annotated locations for NP_001171454.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks several 3' exons but has an alternate 3' exon, as compared to variant 1. The resulting isoform (5) is shorter and has a different C-terminus, as compared to isoform 1.
    Source sequence(s)
    AL772293, AL772358
    Consensus CDS
    CCDS57289.1
    UniProtKB/TrEMBL
    Q80VK8
    Related
    ENSMUSP00000102520.3, ENSMUST00000106907.9

  5. NM_001374780.2 → NP_001361709.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL732551, AL772358, AL807794
    Consensus CDS
    CCDS89787.1
    UniProtKB/TrEMBL
    B1AWC8, Q9QXI7
    Related
    ENSMUSP00000102517.3, ENSMUST00000106904.9
    Conserved Domains (2) summary
    pfam00233
    Location:328 → 569
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:89 → 204
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  6. NM_001404786.1 → NP_001391715.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL732551, AL772293, AL772358
    UniProtKB/TrEMBL
    B1AWC9
    Related
    ENSMUSP00000102524.2, ENSMUST00000106911.8

  7. NM_001404787.1 → NP_001391716.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL772293, AL772358

  8. NM_001404788.1 → NP_001391717.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL772293, AL772358

  9. NM_001404789.1 → NP_001391718.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL732551, AL772293, AL772358, AL807794
    UniProtKB/TrEMBL
    B1AWC8

  10. NM_001404791.1 → NP_001391720.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL732551, AL772293, AL772358

  11. NM_001404793.1 → NP_001391722.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL732551, AL772358

  12. NM_001404794.1 → NP_001391723.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL732551, AL772358

  13. NM_001404796.1 → NP_001391725.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL732551, AL772358

  14. NM_001404804.1 → NP_001391733.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 14

    Status: VALIDATED

    Source sequence(s)
    AL732551, AL772358

  15. NM_001404836.1 → NP_001391765.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 15

    Status: VALIDATED

    Source sequence(s)
    AL732551, AL772358

  16. NM_019840.3 → NP_062814.2  3',5'-cyclic-AMP phosphodiesterase 4B isoform 1

    See identical proteins and their annotated locations for NP_062814.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL732551, AL772293, AL772358
    Consensus CDS
    CCDS18403.1
    UniProtKB/TrEMBL
    Q8VBU5, Q9QXI7
    Related
    ENSMUSP00000102521.3, ENSMUST00000106908.9
    Conserved Domains (1) summary
    pfam00233
    Location:390 → 631
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    101944529..102464459
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502856.2 → XP_006502919.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform X2

    UniProtKB/TrEMBL
    Q9QXI7
    Conserved Domains (2) summary
    pfam00233
    Location:344 → 585
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:105 → 220
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

RNA

  1. XR_004941842.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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