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Pde3b phosphodiesterase 3B, cGMP-inhibited [ Mus musculus (house mouse) ]

Gene ID: 18576, updated on 21-Apr-2024

Summary

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Official Symbol
Pde3bprovided by MGI
Official Full Name
phosphodiesterase 3B, cGMP-inhibitedprovided by MGI
Primary source
MGI:MGI:1333863
See related
Ensembl:ENSMUSG00000030671 AllianceGenome:MGI:1333863
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9830102A01Rik
Summary
Enables protein kinase B binding activity. Acts upstream of or within several processes, including cellular response to insulin stimulus; glucose homeostasis; and regulation of insulin secretion. Located in Golgi apparatus; endoplasmic reticulum; and membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human PDE3B (phosphodiesterase 3B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in mammary gland adult (RPKM 10.0), adrenal adult (RPKM 8.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F1; 7 59.46 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (114014388..114137173)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (114415222..114537938)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4966 Neighboring gene coatomer protein complex, subunit beta 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:121419678-121419787 Neighboring gene STARR-positive B cell enhancer ABC_E9299 Neighboring gene STARR-positive B cell enhancer ABC_E10466 Neighboring gene STARR-positive B cell enhancer mm9_chr7:121444899-121445200 Neighboring gene proteasome subunit alpha 1 Neighboring gene RIKEN cDNA 4933406I18 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:121461019-121461282 Neighboring gene STARR-positive B cell enhancer ABC_E11365 Neighboring gene STARR-seq mESC enhancer starr_19927 Neighboring gene STARR-positive B cell enhancer ABC_E3745 Neighboring gene STARR-positive B cell enhancer mm9_chr7:121575722-121576022 Neighboring gene STARR-positive B cell enhancer ABC_E8203 Neighboring gene STARR-positive B cell enhancer mm9_chr7:121623448-121623749 Neighboring gene STARR-positive B cell enhancer ABC_E9702 Neighboring gene STARR-seq mESC enhancer starr_19929 Neighboring gene STARR-seq mESC enhancer starr_19930 Neighboring gene cytochrome P450, family 2, subfamily r, polypeptide 1 Neighboring gene STARR-seq mESC enhancer starr_19932 Neighboring gene calcitonin/calcitonin-related polypeptide, alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. White to beige conversion in PDE3B KO adipose tissue through activation of AMPK signaling and mitochondrial function. Chung YW, et al. Sci Rep, 2017 Jan 13. PMID 28084425, Free PMC Article
  2. Hypothalamic Phosphodiesterase 3B Pathway Mediates Anorectic and Body Weight-Reducing Effects of Insulin in Male Mice. Sahu M, et al. Neuroendocrinology, 2017. PMID 27002827, Free PMC Article
  3. The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin. DiPilato LM, et al. Mol Cell Biol, 2015 Aug. PMID 26031333, Free PMC Article
  4. A role for phosphodiesterase 3B in acquisition of brown fat characteristics by white adipose tissue in male mice. Guirguis E, et al. Endocrinology, 2013 Sep. PMID 23766131, Free PMC Article
  5. Differences in phosphodiesterase 3A and 3B expression after ischemic insult. Mitome-Mishima Y, et al. Neurosci Res, 2013 Apr. PMID 23471014

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphodiesterase 3B (PDE3B) antagonizes the anti-angiogenic actions of PKA in human and murine endothelial cells.
    Title: Phosphodiesterase 3B (PDE3B) antagonizes the anti-angiogenic actions of PKA in human and murine endothelial cells.
  2. whole-body ablation of PDE3A, but not PDE3B, provided similar protection against TAC-induced adverse ventricular remodeling
    Title: Phosphodiesterase type 3A (PDE3A), but not type 3B (PDE3B), contributes to the adverse cardiac remodeling induced by pressure overload.
  3. microRNA-142-mediated repression of phosphodiesterase 3B critically regulates peripheral immune tolerance.
    Title: microRNA-142-mediated repression of phosphodiesterase 3B critically regulates peripheral immune tolerance.
  4. ABHD15 associates with and stabilizes phosphodiesterase 3B (PDE3B).
    Title: Loss of ABHD15 Impairs the Anti-lipolytic Action of Insulin by Altering PDE3B Stability and Contributes to Insulin Resistance.
  5. Study demonstrated the presence of PDE3 protein and mRNA in human and murine airway tissues and concluded that PDE3A or PDE3B deficiency or pharmacological inhibition of PDE3 may alleviate the symptoms of allergic airway inflammation in a house dust mite-driven allergic airway inflammation mouse model.
    Title: A pathophysiological role of PDE3 in allergic airway inflammation.
  6. PDE3B and/or its downstream signaling partners might be important regulators of energy metabolism in adipose tissue.
    Title: White to beige conversion in PDE3B KO adipose tissue through activation of AMPK signaling and mitochondrial function.
  7. NLRP3 inflammasome-mediated increase of IL1beta , TNFalpha and IL12-p40 in response to Lipopolysaccharides-associated danger signals participate in the development of proinflammatory state, leading to insulin resistance.
    Title: Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue.
  8. Study concludes that CUGBP1 is a critical regulator of insulin secretion via activating PDE3B.
    Title: RNA-binding protein CUGBP1 regulates insulin secretion via activation of phosphodiesterase 3B in mice.
  9. Insulin induction of hypothalamic phosphodiesterase 3B activity and the reversal of the anorectic and body weight-reducing effects and stimulatory effect of insulin on hypothalamic proopiomelanocortin gene expression by cilostamide suggest that activation of phosphodiesterase 3B is a novel mechanism of insulin signaling in the hypothalamus.
    Title: Hypothalamic Phosphodiesterase 3B Pathway Mediates Anorectic and Body Weight-Reducing Effects of Insulin in Male Mice.
  10. These results suggest the possibility for a direct role for the PDE3B pathway in mediating leptin action in the hypothalamus.
    Title: Leptin receptor expressing neurons express phosphodiesterase-3B (PDE3B) and leptin induces STAT3 activation in PDE3B neurons in the mouse hypothalamus.
Submit: New GeneRIF Correction See all GeneRIFs (31)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables 3',5'-cyclic-nucleotide phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase B binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to insulin stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within endocrine pancreas development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within glucose homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of lipid catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of insulin secretion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
part_of guanyl-nucleotide exchange factor complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B
Names
CGI-PDE B
CGIPDE1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B
cyclic GMP-inhibited phosphodiesterase B
NP_035185.2
XP_006507501.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011055.2 → NP_035185.2  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

    Status: VALIDATED

    Source sequence(s)
    AJ132271, AK142889, AV270888, BB627812, BB663310, BU613166, BY745829, CJ058099, CJ299201
    Consensus CDS
    CCDS21760.1
    UniProtKB/Swiss-Prot
    Q61409, Q8CIX5, Q9Z1J9
    UniProtKB/TrEMBL
    E9QLQ3
    Related
    ENSMUSP00000032909.9, ENSMUST00000032909.9
    Conserved Domains (2) summary
    pfam00233
    Location:712 → 986
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam06532
    Location:60 → 241
    DUF1109; Protein of unknown function (DUF1109)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    114014388..114137173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507438.5 → XP_006507501.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform X1

    UniProtKB/Swiss-Prot
    Q61409, Q8CIX5, Q9Z1J9
    Conserved Domains (2) summary
    pfam00233
    Location:695 → 969
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam10101
    Location:116 → 260
    DUF2339; Predicted membrane protein (DUF2339)

RNA

  1. XR_001785490.3 RNA Sequence

  2. XR_003946416.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61409.2 GenPept UniProtKB/Swiss-Prot:Q61409

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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